Gesell J - Search Results

1

Discovery of an irreversible HCV NS5B polymerase inhibitor.

Zeng Q, Nair AG, Rosenblum SB, Huang HC, Lesburg CA, Jiang Y, Selyutin O, Chan TY, Bennett F, Chen KX, Venkatraman S, Sannigrahi M, Velazquez F, Duca JS, Gavalas S, Huang Y, Pu H, Wang L, Pinto P, Vibulbhan B, Agrawal S, Ferrari E, Jiang CK, Li C, Hesk D, Gesell J, Sorota S, Shih NY, Njoroge FG, Kozlowski JA. Zeng Q, et al. Among authors: gesell j. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6585-7. doi: 10.1016/j.bmcl.2013.10.060. Epub 2013 Nov 6. Bioorg Med Chem Lett. 2013. PMID: 24252545

2

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.

Bungard CJ, Williams PD, Ballard JE, Bennett DJ, Beaulieu C, Bahnck-Teets C, Carroll SS, Chang RK, Dubost DC, Fay JF, Diamond TL, Greshock TJ, Hao L, Holloway MK, Felock PJ, Gesell JJ, Su HP, Manikowski JJ, McKay DJ, Miller M, Min X, Molinaro C, Moradei OM, Nantermet PG, Nadeau C, Sanchez RI, Satyanarayana T, Shipe WD, Singh SK, Truong VL, Vijayasaradhi S, Wiscount CM, Vacca JP, Crane SN, McCauley JA. Bungard CJ, et al. Among authors: gesell jj. ACS Med Chem Lett. 2016 May 9;7(7):702-7. doi: 10.1021/acsmedchemlett.6b00135. eCollection 2016 Jul 14. ACS Med Chem Lett. 2016. PMID: 27437081 Free PMC article.

3

Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies.

Gesell JJ, Liu D, Madison VS, Hesson T, Wang YS, Weber PC, Wyss DF. Gesell JJ, et al. Protein Eng. 2001 Aug;14(8):573-82. doi: 10.1093/protein/14.8.573. Protein Eng. 2001. PMID: 11579226

4

Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase.

Liu D, Wang YS, Gesell JJ, Wyss DF. Liu D, et al. Among authors: gesell jj. J Mol Biol. 2001 Nov 30;314(3):543-61. doi: 10.1006/jmbi.2001.5146. J Mol Biol. 2001. PMID: 11846566

5

Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction.

Zhang R, Mayhood T, Lipari P, Wang Y, Durkin J, Syto R, Gesell J, McNemar C, Windsor W. Zhang R, et al. Among authors: gesell j. Anal Biochem. 2004 Aug 1;331(1):138-46. doi: 10.1016/j.ab.2004.03.009. Anal Biochem. 2004. PMID: 15246006

6

Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex.

McCoy MA, Senior MM, Gesell JJ, Ramanathan L, Wyss DF. McCoy MA, et al. Among authors: gesell jj. J Mol Biol. 2001 Feb 2;305(5):1099-110. doi: 10.1006/jmbi.2000.4365. J Mol Biol. 2001. PMID: 11162117

7

In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors.

Salowe SP, Zhang L, Zokian HJ, Gesell JJ, Zink DL, Wiltsie J, Ai X, Kavana M, Pinto S. Salowe SP, et al. Among authors: gesell jj. J Biomol Screen. 2016 Dec;21(10):1034-1041. doi: 10.1177/1087057116657312. Epub 2016 Jul 11. J Biomol Screen. 2016. PMID: 27412534

8

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation.

McCoy MA, Gesell JJ, Senior MM, Wyss DF. McCoy MA, et al. Among authors: gesell jj. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1645-8. doi: 10.1073/pnas.0334477100. Epub 2003 Jan 27. Proc Natl Acad Sci U S A. 2003. PMID: 12552135 Free PMC article.

9

Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1.

Liu D, Wang YS, Gesell JJ, Wilson E, Beyer BM, Wyss DF. Liu D, et al. Among authors: gesell jj. J Biomol NMR. 2004 Jul;29(3):425-6. doi: 10.1023/B:JNMR.0000032509.81283.d3. J Biomol NMR. 2004. PMID: 15213451 No abstract available.

10

A simple protocol for identification of helical and mobile residues in membrane proteins.

Tobias DJ, Gesell J, Klein ML, Opella SJ. Tobias DJ, et al. Among authors: gesell j. J Mol Biol. 1995 Oct 27;253(3):391-5. doi: 10.1006/jmbi.1995.0561. J Mol Biol. 1995. PMID: 7473722 Free article.

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