Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors.
Garcia-Lavandeira M, Saez C, Diaz-Rodriguez E, Perez-Romero S, Senra A, Dieguez C, Japon MA, Alvarez CV.
Garcia-Lavandeira M, et al.
J Clin Endocrinol Metab. 2012 Jan;97(1):E80-7. doi: 10.1210/jc.2011-2187. Epub 2011 Oct 26.
J Clin Endocrinol Metab. 2012.
PMID: 22031517
CRF maintain the expression of SOX2, OCT4, KLF4, SOX9, and beta-catenin. However, RET and GFRA3 expression was altered in CRF. In 25% (five of 20), both RET and GFRA3 were detected but not colocalized in the same cells. ...Redundancy in RET coreceptor expression (GF …
CRF maintain the expression of SOX2, OCT4, KLF4, SOX9, and beta-catenin. However, RET and GFRA3 expression was altered in CRF. In 25% …