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Did you mean gyral (1,277 results)?
The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?
Breit SN, Brown DA, Tsai VW. Breit SN, et al. Annu Rev Physiol. 2021 Feb 10;83:127-151. doi: 10.1146/annurev-physiol-022020-045449. Epub 2020 Nov 23. Annu Rev Physiol. 2021. PMID: 33228454 Review.
It acts through a recently identified orphan member of the GFRalpha family called GFRAL and signals through the Ret coreceptor. Cell stress and disease lead to elevated GDF15 serum levels, causing anorexia, weight loss, and alterations to metabolism, largely by actions on …
It acts through a recently identified orphan member of the GFRalpha family called GFRAL and signals through the Ret coreceptor. Cell …
GFRAL-expressing neurons suppress food intake via aversive pathways.
Sabatini PV, Frikke-Schmidt H, Arthurs J, Gordian D, Patel A, Rupp AC, Adams JM, Wang J, Beck Jørgensen S, Olson DP, Palmiter RD, Myers MG Jr, Seeley RJ. Sabatini PV, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118. doi: 10.1073/pnas.2021357118. Proc Natl Acad Sci U S A. 2021. PMID: 33593916 Free PMC article.
Because the brainstem-restricted expression pattern of its receptor, GDNF Family Receptor alpha-like (GFRAL), presents an exciting opportunity to understand mechanisms of action for area postrema neurons in food intake; we generated Gfral(Cre) and conditional Gfr …
Because the brainstem-restricted expression pattern of its receptor, GDNF Family Receptor alpha-like (GFRAL), presents an exciting op …
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, Nørgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, Jørgensen SB. Yang L, et al. Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846099
Here we show that GDF15 binds specifically to GDNF family receptor alpha-like (GFRAL) with high affinity, and that GFRAL requires association with the coreceptor RET to elicit intracellular signaling in response to GDF15 stimulation. We also found that GDF15-mediate …
Here we show that GDF15 binds specifically to GDNF family receptor alpha-like (GFRAL) with high affinity, and that GFRAL requi …
The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.
Tsai VWW, Husaini Y, Sainsbury A, Brown DA, Breit SN. Tsai VWW, et al. Cell Metab. 2018 Sep 4;28(3):353-368. doi: 10.1016/j.cmet.2018.07.018. Cell Metab. 2018. PMID: 30184485 Free article. Review.
It acts via a recently identified receptor called glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL), which is a distant orphan member of the GDNF receptor family that signals through the tyrosine kinase receptor Ret. ...
It acts via a recently identified receptor called glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL), which is a di …
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098
Gfral(-/-) mice were refractory to the effects of recombinant human GDF15 on body-weight, food-intake and glucose parameters. ...Together, our data demonstrate that GFRAL is a receptor for GDF15 that mediates the metabolic effects of GDF15....
Gfral(-/-) mice were refractory to the effects of recombinant human GDF15 on body-weight, food-intake and glucose parameters. ...Toge …
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ, Rangwala SM. Mullican SE, et al. Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038/nm.4392. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846097
In addition, diet-induced obesity and insulin resistance are exacerbated in GFRAL-deficient mice, suggesting a homeostatic role for this receptor in metabolism. Finally, we demonstrate that GDF15-induced cell signaling requires the interaction of GFRAL with the core …
In addition, diet-induced obesity and insulin resistance are exacerbated in GFRAL-deficient mice, suggesting a homeostatic role for t …
Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Suriben R, Chen M, Higbee J, Oeffinger J, Ventura R, Li B, Mondal K, Gao Z, Ayupova D, Taskar P, Li D, Starck SR, Chen HH, McEntee M, Katewa SD, Phung V, Wang M, Kekatpure A, Lakshminarasimhan D, White A, Olland A, Haldankar R, Solloway MJ, Hsu JY, Wang Y, Tang J, Lindhout DA, Allan BB. Suriben R, et al. Nat Med. 2020 Aug;26(8):1264-1270. doi: 10.1038/s41591-020-0945-x. Epub 2020 Jul 13. Nat Med. 2020. PMID: 32661391
Elevation in circulating growth differentiation factor 15 (GDF15) correlates with cachexia and reduced survival in patients with cancer(5-8), and a GDNF family receptor alpha like (GFRAL)-Ret proto-oncogene (RET) signaling complex in brainstem neurons that mediates GDF15-i …
Elevation in circulating growth differentiation factor 15 (GDF15) correlates with cachexia and reduced survival in patients with cancer(5-8) …
GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.
Ahmed DS, Isnard S, Lin J, Routy B, Routy JP. Ahmed DS, et al. J Cancer. 2021 Jan 1;12(4):1125-1132. doi: 10.7150/jca.50376. eCollection 2021. J Cancer. 2021. PMID: 33442410 Free PMC article. Review.
The recent discovery of its receptor, glial cell line-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL), sheds light on its metabolic function. Herein, we critically review the mechanisms involving GDF15 in cancer cachexia and discuss therapeutic interv …
The recent discovery of its receptor, glial cell line-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL), sheds li …
The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance.
Klein AB, Nicolaisen TS, Johann K, Fritzen AM, Mathiesen CV, Gil C, Pilmark NS, Karstoft K, Blond MB, Quist JS, Seeley RJ, Færch K, Lund J, Kleinert M, Clemmensen C. Klein AB, et al. Cell Rep. 2022 Aug 23;40(8):111258. doi: 10.1016/j.celrep.2022.111258. Cell Rep. 2022. PMID: 36001956 Free article.
Recently, it was reported that metformin lowers body weight via induction of growth differentiation factor 15 (GDF15), which suppresses food intake by binding to the GDNF family receptor alpha-like (GFRAL) in the hindbrain. Here, we corroborate that metformin increases cir …
Recently, it was reported that metformin lowers body weight via induction of growth differentiation factor 15 (GDF15), which suppresses food …
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL.
Chow CFW, Guo X, Asthana P, Zhang S, Wong SKK, Fallah S, Che S, Gurung S, Wang Z, Lee KB, Ge X, Yuan S, Xu H, Ip JPK, Jiang Z, Zhai L, Wu J, Zhang Y, Mahato AK, Saarma M, Lin CY, Kwan HY, Huang T, Lyu A, Zhou Z, Bian ZX, Wong HLX. Chow CFW, et al. Nat Metab. 2022 Feb;4(2):203-212. doi: 10.1038/s42255-022-00529-5. Epub 2022 Feb 17. Nat Metab. 2022. PMID: 35177851
Overnutrition-induced obesity increased MT1-MMP activation, which proteolytically inactivated GFRAL to suppress GDF15-GFRAL signaling, thus modulating the anorectic effects of the GDF15-GFRAL axis in vivo. Genetic ablation of MT1-MMP specifically in GFRAL …
Overnutrition-induced obesity increased MT1-MMP activation, which proteolytically inactivated GFRAL to suppress GDF15-GFRAL si …
122 results