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Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria.
Saathoff M, Kosol S, Semmler T, Tedin K, Dimos N, Kupke J, Seidel M, Ghazisaeedi F, Jonske MC, Wolf SA, Kuropka B, Czyszczoń W, Ghilarov D, Grätz S, Heddle JG, Loll B, Süssmuth RD, Fulde M. Saathoff M, et al. Among authors: ghilarov d. PLoS Biol. 2023 Aug 10;21(8):e3002186. doi: 10.1371/journal.pbio.3002186. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37561817 Free PMC article.
Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin.
Michalczyk E, Hommernick K, Behroz I, Kulike M, Pakosz-Stępień Z, Mazurek L, Seidel M, Kunert M, Santos K, von Moeller H, Loll B, Weston JB, Mainz A, Heddle JG, Süssmuth RD, Ghilarov D. Michalczyk E, et al. Among authors: ghilarov d. Nat Catal. 2023;6(1):52-67. doi: 10.1038/s41929-022-00904-1. Epub 2023 Jan 23. Nat Catal. 2023. PMID: 36741192 Free PMC article.
Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Metelev M, Osterman IA, Ghilarov D, Khabibullina NF, Yakimov A, Shabalin K, Utkina I, Travin DY, Komarova ES, Serebryakova M, Artamonova T, Khodorkovskii M, Konevega AL, Sergiev PV, Severinov K, Polikanov YS. Metelev M, et al. Among authors: ghilarov d. Nat Chem Biol. 2017 Oct;13(10):1129-1136. doi: 10.1038/nchembio.2462. Epub 2017 Aug 28. Nat Chem Biol. 2017. PMID: 28846667 Free PMC article.
The bacteriophage LUZ24 "Igy" peptide inhibits the Pseudomonas DNA gyrase.
De Smet J, Wagemans J, Boon M, Ceyssens PJ, Voet M, Noben JP, Andreeva J, Ghilarov D, Severinov K, Lavigne R. De Smet J, et al. Among authors: ghilarov d. Cell Rep. 2021 Aug 24;36(8):109567. doi: 10.1016/j.celrep.2021.109567. Cell Rep. 2021. PMID: 34433028 Free article.
14 results