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Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation.
Van der Jeught M, Heindryckx B, O'Leary T, Duggal G, Ghimire S, Lierman S, Van Roy N, Chuva de Sousa Lopes SM, Deroo T, Deforce D, De Sutter P. Van der Jeught M, et al. Among authors: ghimire s. Hum Reprod. 2014 Jan;29(1):41-8. doi: 10.1093/humrep/det400. Epub 2013 Nov 19. Hum Reprod. 2014. PMID: 24256991
Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice.
Neupane J, Vandewoestyne M, Ghimire S, Lu Y, Qian C, Van Coster R, Gerris J, Deroo T, Deforce D, De Sutter P, Heindryckx B. Neupane J, et al. Among authors: ghimire s. Mitochondrion. 2014 Sep;18:27-33. doi: 10.1016/j.mito.2014.09.003. Epub 2014 Sep 16. Mitochondrion. 2014. PMID: 25229667
The combination of inhibitors of FGF/MEK/Erk and GSK3β signaling increases the number of OCT3/4- and NANOG-positive cells in the human inner cell mass, but does not improve stem cell derivation.
Van der Jeught M, O'Leary T, Ghimire S, Lierman S, Duggal G, Versieren K, Deforce D, Chuva de Sousa Lopes S, Heindryckx B, De Sutter P. Van der Jeught M, et al. Among authors: ghimire s. Stem Cells Dev. 2013 Jan 15;22(2):296-306. doi: 10.1089/scd.2012.0256. Epub 2012 Aug 6. Stem Cells Dev. 2013. PMID: 22784186 Free PMC article.
Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background.
Ghimire S, Van der Jeught M, Neupane J, Roost MS, Anckaert J, Popovic M, Van Nieuwerburgh F, Mestdagh P, Vandesompele J, Deforce D, Menten B, Chuva de Sousa Lopes S, De Sutter P, Heindryckx B. Ghimire S, et al. Sci Rep. 2018 Apr 12;8(1):5884. doi: 10.1038/s41598-018-24051-5. Sci Rep. 2018. PMID: 29650979 Free PMC article.
Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells.
Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, Deroo T, Peelman L, Van Soom A, Cornelissen R, Menten B, Mestdagh P, Vandesompele J, Roost M, Slieker RC, Heijmans BT, Deforce D, De Sutter P, De Sousa Lopes SC, Heindryckx B. Duggal G, et al. Among authors: ghimire s. Stem Cells. 2015 Sep;33(9):2686-98. doi: 10.1002/stem.2071. Epub 2015 Jun 24. Stem Cells. 2015. PMID: 26108678
496 results