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4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release.
Ayer LM, Wilson SM, Traves SL, Proud D, Giembycz MA. Ayer LM, et al. Among authors: giembycz ma. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26. doi: 10.1124/jpet.107.129312. Epub 2007 Oct 25. J Pharmacol Exp Ther. 2008. PMID: 17962517
Phosphodiesterase 4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells: a novel mechanism for the clinical efficacy of roflumilast in severe chronic obstructive pulmonary disease.
Moodley T, Wilson SM, Joshi T, Rider CF, Sharma P, Yan D, Newton R, Giembycz MA. Moodley T, et al. Among authors: giembycz ma. Mol Pharmacol. 2013 Apr;83(4):894-906. doi: 10.1124/mol.112.083493. Epub 2013 Feb 6. Mol Pharmacol. 2013. PMID: 23389862
Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.
Kaur M, Holden NS, Wilson SM, Sukkar MB, Chung KF, Barnes PJ, Newton R, Giembycz MA. Kaur M, et al. Among authors: giembycz ma. Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L505-14. doi: 10.1152/ajplung.00046.2008. Epub 2008 Jun 27. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18586957 Free article.
Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.
Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R. Holden NS, et al. Among authors: giembycz ma. J Pharmacol Exp Ther. 2014 Jan;348(1):12-24. doi: 10.1124/jpet.113.204586. Epub 2013 Oct 25. J Pharmacol Exp Ther. 2014. PMID: 24163441
Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease.
Greer S, Page CW, Joshi T, Yan D, Newton R, Giembycz MA. Greer S, et al. Among authors: giembycz ma. J Pharmacol Exp Ther. 2013 Sep;346(3):473-85. doi: 10.1124/jpet.113.206284. Epub 2013 Jul 2. J Pharmacol Exp Ther. 2013. PMID: 23820127
168 results