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Page 1
Solution Conformations Shed Light on PROTAC Cell Permeability.
Atilaw Y, Poongavanam V, Svensson Nilsson C, Nguyen D, Giese A, Meibom D, Erdelyi M, Kihlberg J. Atilaw Y, et al. Among authors: giese a. ACS Med Chem Lett. 2020 Dec 25;12(1):107-114. doi: 10.1021/acsmedchemlett.0c00556. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488971 Free PMC article.
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability.
Poongavanam V, Atilaw Y, Siegel S, Giese A, Lehmann L, Meibom D, Erdelyi M, Kihlberg J. Poongavanam V, et al. Among authors: giese a. J Med Chem. 2022 Oct 13;65(19):13029-13040. doi: 10.1021/acs.jmedchem.2c00877. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170570 Free PMC article.
Predictive Modeling of PROTAC Cell Permeability with Machine Learning.
Poongavanam V, Kölling F, Giese A, Göller AH, Lehmann L, Meibom D, Kihlberg J. Poongavanam V, et al. Among authors: giese a. ACS Omega. 2023 Feb 1;8(6):5901-5916. doi: 10.1021/acsomega.2c07717. eCollection 2023 Feb 14. ACS Omega. 2023. PMID: 36816707 Free PMC article.
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
Rahm F, Viklund J, Trésaugues L, Ellermann M, Giese A, Ericsson U, Forsblom R, Ginman T, Günther J, Hallberg K, Lindström J, Persson LB, Silvander C, Talagas A, Díaz-Sáez L, Fedorov O, Huber KVM, Panagakou I, Siejka P, Gorjánácz M, Bauser M, Andersson M. Rahm F, et al. Among authors: giese a. J Med Chem. 2018 Mar 22;61(6):2533-2551. doi: 10.1021/acs.jmedchem.7b01884. Epub 2018 Mar 7. J Med Chem. 2018. PMID: 29485874
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T, Lindström J, Silvander C, Trésaugues L, Giese A, Bunse S, Neuhaus R, Weiske J, Quanz M, Glasauer A, Nowak-Reppel K, Bader B, Irlbacher H, Meyer H, Queisser N, Bauser M, Haegebarth A, Gorjánácz M. Ellermann M, et al. Among authors: giese a. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. doi: 10.1021/acschembio.7b00370. Epub 2017 Jul 12. ACS Chem Biol. 2017. PMID: 28679043 Free article.
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Böhnke N, Berger M, Griebenow N, Rottmann A, Erkelenz M, Hammer S, Berndt S, Günther J, Wengner AM, Stelte-Ludwig B, Mahlert C, Greven S, Dietz L, Jörißen H, Barak N, Bömer U, Hillig RC, Eberspaecher U, Weiske J, Giese A, Mumberg D, Nising CF, Weinmann H, Sommer A. Böhnke N, et al. Among authors: giese a. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221. doi: 10.1021/acs.bioconjchem.2c00178. Epub 2022 Jun 3. Bioconjug Chem. 2022. PMID: 35658441 Free PMC article.
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.
Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, Bernhardt A, Perrin RJ, Jucker M, Preische O, Hofmann A, Höglinger GU, Cairns NJ, Franklin EE, Chrem P, Cruchaga C, Berman SB, Chhatwal JP, Daniels A, Day GS, Ryan NS, Goate AM, Gordon BA, Huey ED, Ibanez L, Karch CM, Lee JH, Llibre-Guerra J, Lopera F, Masters CL, Morris JC, Noble JM, Renton AE, Roh JH, Frosch MP, Keene CD, McLean C, Sanchez-Valle R, Schofield PR, Supnet-Bell C, Xiong C, Giese A, Hansson O, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network; Parchi P. Levin J, et al. Among authors: giese a. Alzheimers Dement. 2024 Apr 26. doi: 10.1002/alz.13818. Online ahead of print. Alzheimers Dement. 2024. PMID: 38666355
Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor.
Seeneevassen L, Zaafour A, Sifré E, Genevois C, Nguyen TL, Pobiedonoscew Y, Giese A, Guignard J, Tiffon C, Rousseau B, Raymond AA, Belleannée G, Boeuf H, Gronnier C, Martin OCB, Giraud J, Lehours P, Dubus P, Varon C. Seeneevassen L, et al. Among authors: giese a. Cell Death Discov. 2024 Mar 7;10(1):120. doi: 10.1038/s41420-024-01839-1. Cell Death Discov. 2024. PMID: 38453889 Free PMC article.
LIONS PREY: A New Logistic Scoring System for the Prediction of Malignant Pulmonary Nodules.
Doerr F, Giese A, Höpker K, Menghesha H, Schlachtenberger G, Grapatsas K, Baldes N, Baldus CJ, Hagmeyer L, Fallouh H, Pinto Dos Santos D, Bender EM, Quaas A, Heldwein M, Wahlers T, Hautzel H, Darwiche K, Taube C, Schuler M, Hekmat K, Bölükbas S. Doerr F, et al. Among authors: giese a. Cancers (Basel). 2024 Feb 9;16(4):729. doi: 10.3390/cancers16040729. Cancers (Basel). 2024. PMID: 38398120 Free PMC article.
669 results