Gilbert IH - Search Results

1

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase.

Whittingham JL, Carrero-Lerida J, Brannigan JA, Ruiz-Perez LM, Silva AP, Fogg MJ, Wilkinson AJ, Gilbert IH, Wilson KS, González-Pacanowska D. Whittingham JL, et al. Among authors: gilbert ih. Biochem J. 2010 May 27;428(3):499-509. doi: 10.1042/BJ20091880. Biochem J. 2010. PMID: 20353400

2

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Zuccotto F, Brun R, Gonzalez Pacanowska D, Ruiz Perez LM, Gilbert IH. Zuccotto F, et al. Among authors: gilbert ih. Bioorg Med Chem Lett. 1999 May 17;9(10):1463-8. doi: 10.1016/s0960-894x(99)00213-9. Bioorg Med Chem Lett. 1999. PMID: 10360757

3

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Zuccotto F, Zvelebil M, Brun R, Chowdhury SF, Di Lucrezia R, Leal I, Maes L, Ruiz-Perez LM, Gonzalez Pacanowska D, Gilbert IH. Zuccotto F, et al. Among authors: gilbert ih. Eur J Med Chem. 2001 May;36(5):395-405. doi: 10.1016/s0223-5234(01)01235-1. Eur J Med Chem. 2001. PMID: 11451529

4

Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase.

Chowdhury SF, Guerrero RH, Brun R, Ruiz-Perez LM, Pacanowska DG, Gilbert IH. Chowdhury SF, et al. Among authors: gilbert ih. J Enzyme Inhib Med Chem. 2002 Oct;17(5):293-302. doi: 10.1080/1475636021000059083. J Enzyme Inhib Med Chem. 2002. PMID: 12683746

5

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase.

Pez D, Leal I, Zuccotto F, Boussard C, Brun R, Croft SL, Yardley V, Ruiz Perez LM, Gonzalez Pacanowska D, Gilbert IH. Pez D, et al. Among authors: gilbert ih. Bioorg Med Chem. 2003 Nov 3;11(22):4693-711. doi: 10.1016/j.bmc.2003.08.012. Bioorg Med Chem. 2003. PMID: 14556785

6

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

Magaraci F, Jimenez CJ, Rodrigues C, Rodrigues JC, Braga MV, Yardley V, de Luca-Fradley K, Croft SL, de Souza W, Ruiz-Perez LM, Urbina J, Gonzalez Pacanowska D, Gilbert IH. Magaraci F, et al. Among authors: gilbert ih. J Med Chem. 2003 Oct 23;46(22):4714-27. doi: 10.1021/jm021114j. J Med Chem. 2003. PMID: 14561091

7

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

Lorente SO, Rodrigues JC, Jiménez Jiménez C, Joyce-Menekse M, Rodrigues C, Croft SL, Yardley V, de Luca-Fradley K, Ruiz-Pérez LM, Urbina J, de Souza W, González Pacanowska D, Gilbert IH. Lorente SO, et al. Among authors: gilbert ih. Antimicrob Agents Chemother. 2004 Aug;48(8):2937-50. doi: 10.1128/AAC.48.8.2937-2950.2004. Antimicrob Agents Chemother. 2004. PMID: 15273104 Free PMC article.

8

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

Whittingham JL, Leal I, Nguyen C, Kasinathan G, Bell E, Jones AF, Berry C, Benito A, Turkenburg JP, Dodson EJ, Ruiz Perez LM, Wilkinson AJ, Johansson NG, Brun R, Gilbert IH, Gonzalez Pacanowska D, Wilson KS. Whittingham JL, et al. Among authors: gilbert ih. Structure. 2005 Feb;13(2):329-38. doi: 10.1016/j.str.2004.11.015. Structure. 2005. PMID: 15698576 Free article.

9

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

Khabnadideh S, Pez D, Musso A, Brun R, Pérez LM, González-Pacanowska D, Gilbert IH. Khabnadideh S, et al. Among authors: gilbert ih. Bioorg Med Chem. 2005 Apr 1;13(7):2637-49. doi: 10.1016/j.bmc.2005.01.025. Bioorg Med Chem. 2005. PMID: 15755663

10

Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.

Orenes Lorente S, Gómez R, Jiménez C, Cammerer S, Yardley V, de Luca-Fradley K, Croft SL, Ruiz Perez LM, Urbina J, Gonzalez Pacanowska D, Gilbert IH. Orenes Lorente S, et al. Among authors: gilbert ih. Bioorg Med Chem. 2005 May 16;13(10):3519-29. doi: 10.1016/j.bmc.2005.02.060. Bioorg Med Chem. 2005. PMID: 15848765

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