Giraldo J - Search Results

1

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors.

Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C. Rovira X, et al. Among authors: giraldo j. FASEB J. 2015 Jan;29(1):116-30. doi: 10.1096/fj.14-257287. Epub 2014 Oct 23. FASEB J. 2015. PMID: 25342125

2

The catalytic power of enzymes: conformational selection or transition state stabilization?

Giraldo J, Roche D, Rovira X, Serra J. Giraldo J, et al. FEBS Lett. 2006 Apr 17;580(9):2170-7. doi: 10.1016/j.febslet.2006.03.060. Epub 2006 Mar 30. FEBS Lett. 2006. PMID: 16616138 Free article.

3

Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited.

Giraldo J, Serra J, Roche D, Rovira X. Giraldo J, et al. Curr Drug Targets. 2007 Jan;8(1):197-202. doi: 10.2174/138945007779315687. Curr Drug Targets. 2007. PMID: 17266542 Review.

4

Modeling the binding and function of metabotropic glutamate receptors.

Rovira X, Roche D, Serra J, Kniazeff J, Pin JP, Giraldo J. Rovira X, et al. Among authors: giraldo j. J Pharmacol Exp Ther. 2008 May;325(2):443-56. doi: 10.1124/jpet.107.133967. Epub 2008 Feb 20. J Pharmacol Exp Ther. 2008. PMID: 18287211 Free article.

5

Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system.

Rovira X, Vivó M, Serra J, Roche D, Strange PG, Giraldo J. Rovira X, et al. Among authors: giraldo j. Br J Pharmacol. 2009 Jan;156(1):28-35. doi: 10.1111/j.1476-5381.2008.00031.x. Br J Pharmacol. 2009. PMID: 19133989 Free PMC article. Review.

6

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.

Rovira X, Pin JP, Giraldo J. Rovira X, et al. Among authors: giraldo j. Trends Pharmacol Sci. 2010 Jan;31(1):15-21. doi: 10.1016/j.tips.2009.10.008. Epub 2009 Dec 4. Trends Pharmacol Sci. 2010. PMID: 19963287 Review.

7

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

Christov C, González-Bulnes P, Malhaire F, Karabencheva T, Goudet C, Pin JP, Llebaria A, Giraldo J. Christov C, et al. Among authors: giraldo j. ChemMedChem. 2011 Jan 3;6(1):131-40. doi: 10.1002/cmdc.201000378. ChemMedChem. 2011. PMID: 21132834

8

Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism.

Roche D, Gil D, Giraldo J. Roche D, et al. Among authors: giraldo j. Drug Discov Today. 2013 Apr;18(7-8):365-71. doi: 10.1016/j.drudis.2012.12.004. Epub 2012 Dec 13. Drug Discov Today. 2013. PMID: 23247260

9

Modeling cooperativity effects in dimeric G protein-coupled receptors.

Giraldo J. Giraldo J. Prog Mol Biol Transl Sci. 2013;115:349-73. doi: 10.1016/B978-0-12-394587-7.00008-7. Prog Mol Biol Transl Sci. 2013. PMID: 23415098 Review.

10

Mechanistic analysis of the function of agonists and allosteric modulators: reconciling two-state and operational models.

Roche D, Gil D, Giraldo J. Roche D, et al. Among authors: giraldo j. Br J Pharmacol. 2013 Jul;169(6):1189-202. doi: 10.1111/bph.12231. Br J Pharmacol. 2013. PMID: 23647200 Free PMC article. Review.

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