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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1976 1
1977 1
1978 1
1979 1
1980 1
1981 1
1982 4
1984 4
1985 2
1986 3
1987 4
1988 3
1989 4
1990 5
1991 6
1992 7
1993 15
1994 10
1995 11
1996 10
1997 20
1998 12
1999 13
2000 17
2001 12
2002 19
2003 20
2004 23
2005 29
2006 29
2007 28
2008 35
2009 50
2010 65
2011 69
2012 94
2013 155
2014 191
2015 238
2016 298
2017 342
2018 406
2019 546
2020 635
2021 795
2022 857
2023 857
2024 380

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5,435 results

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Page 1
Identification of GLS as a cuproptosis-related diagnosis gene in acute myocardial infarction.
Liu Z, Wang L, Xing Q, Liu X, Hu Y, Li W, Yan Q, Liu R, Huang N. Liu Z, et al. Front Cardiovasc Med. 2022 Nov 11;9:1016081. doi: 10.3389/fcvm.2022.1016081. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36440046 Free PMC article.
The results showed that six CRGs (LIAS, LIPT1, DLAT, PDHB, MTF1, and GLS) were markedly differentially expressed between stable coronary heart disease (stable_CAD) and AMI. ...Immune landscape analysis results revealed that CRGs were closely related to various immune cells …
The results showed that six CRGs (LIAS, LIPT1, DLAT, PDHB, MTF1, and GLS) were markedly differentially expressed between stable coron …
GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.
Rumping L, Tessadori F, Pouwels PJW, Vringer E, Wijnen JP, Bhogal AA, Savelberg SMC, Duran KJ, Bakkers MJG, Ramos RJJ, Schellekens PAW, Kroes HY, Klomp DWJ, Black GCM, Taylor RL, Bakkers JPW, Prinsen HCMT, van der Knaap MS, Dansen TB, Rehmann H, Zwartkruis FJT, Houwen RHJ, van Haaften G, Verhoeven-Duif NM, Jans JJM, van Hasselt PM. Rumping L, et al. Hum Mol Genet. 2019 Jan 1;28(1):96-104. doi: 10.1093/hmg/ddy330. Hum Mol Genet. 2019. PMID: 30239721
We report a de novo Ser482Cys gain-of-function variant in GLS encoding GLS associated with profound developmental delay and infantile cataract. ...Ser482Cys-GLS likely improves the electrostatic environment of the GLS catalytic site, thereby intrinsica …
We report a de novo Ser482Cys gain-of-function variant in GLS encoding GLS associated with profound developmental delay and in …
GLS as a diagnostic biomarker in breast cancer: in-silico, in-situ, and in-vitro insights.
Zhang D, Wang M, Huang X, Wang L, Liu Y, Zhou S, Tang Y, Wang Q, Li Z, Wang G. Zhang D, et al. Front Oncol. 2023 Aug 18;13:1220038. doi: 10.3389/fonc.2023.1220038. eCollection 2023. Front Oncol. 2023. PMID: 37664031 Free PMC article.
In the present study, we comprehensively investigated the core gene of this mechanism, GLS, in breast cancer. MATERIALS AND METHODS: Bulk RNA sequencing data were curated from the TCGA repository to investigate the aberrant expression of GLS over diverse cancer type …
In the present study, we comprehensively investigated the core gene of this mechanism, GLS, in breast cancer. MATERIALS AND METHODS: …
Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer.
Zhang J, Mao S, Guo Y, Wu Y, Yao X, Huang Y. Zhang J, et al. Biosci Rep. 2019 Jun 25;39(6):BSR20181826. doi: 10.1042/BSR20181826. Print 2019 Jun 28. Biosci Rep. 2019. PMID: 31196962 Free PMC article.
However, the precise function of GLS in prostate cancer (PCa) remains unclear. The purpose of the present study was to assess the GLS expression and its clinical significance in PCa. ...Functionally, we silenced GLS in PCa cell lines and revealed that GLS …
However, the precise function of GLS in prostate cancer (PCa) remains unclear. The purpose of the present study was to assess the …
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity.
Rumping L, Pras-Raves ML, Gerrits J, Tang YF, Willemsen MA, Houwen RHJ, van Haaften G, van Hasselt PM, Verhoeven-Duif NM, Jans JJM. Rumping L, et al. Biochim Biophys Acta Gen Subj. 2020 Mar;1864(3):129484. doi: 10.1016/j.bbagen.2019.129484. Epub 2019 Nov 14. Biochim Biophys Acta Gen Subj. 2020. PMID: 31734463 Free article.
BACKGROUND: High glutaminase (GLS;EC3.5.1.2) activity is an important pathophysiological phenomenon in tumorigenesis and metabolic disease. ...METHODS: We developed a HEK293-based cell-model that enables tuning of GLS activity by combining the expression of a hyperm …
BACKGROUND: High glutaminase (GLS;EC3.5.1.2) activity is an important pathophysiological phenomenon in tumorigenesis and metabolic di …
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Duvall B, Zimmermann SC, Gao RD, Thomas AG, Kalčic F, Veeravalli V, Elgogary A, Rais R, Rojas C, Le A, Slusher BS, Tsukamoto T. Duvall B, et al. Bioorg Med Chem. 2020 Oct 15;28(20):115698. doi: 10.1016/j.bmc.2020.115698. Epub 2020 Aug 6. Bioorg Med Chem. 2020. PMID: 33069080 Free PMC article.
A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl (SCH(2)CH(2)) linker were synthesized in an effort to further expand the structural diversity of chemotypes derived from bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide …
A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl (SCH(2)CH(2)) linker were synthesized in a …
Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors.
Azizi MS, Nasution SA, Setiati S, Shatri H. Azizi MS, et al. Acta Med Indones. 2020 Jan;52(1):47-54. Acta Med Indones. 2020. PMID: 32291371 Free article.
One method used in the early detection of LVSD is an assessment of global longitudinal strain (GLS). This study aimed to determine the mean value of GLS and GLS-related factors. ...The factors that influence the decrease of GLS are frailty and diabetes …
One method used in the early detection of LVSD is an assessment of global longitudinal strain (GLS). This study aimed to determine th …
Preclinical Characterization of GLS-010 (Zimberelimab), a Novel Fully Human Anti-PD-1 Therapeutic Monoclonal Antibody for Cancer.
Lou B, Wei H, Yang F, Wang S, Yang B, Zheng Y, Zhu J, Yan S. Lou B, et al. Front Oncol. 2021 Sep 15;11:736955. doi: 10.3389/fonc.2021.736955. eCollection 2021. Front Oncol. 2021. PMID: 34604074 Free PMC article.
AIM: To evaluate the affinity, competitive blocking capability, T cell activation effect, cytotoxic effector functions by Fc, preliminary anti-tumor activity, and pharmacokinetics of GLS-010. METHODS: The affinity of GLS-010 to PD-1 and the ability of GLS-010 …
AIM: To evaluate the affinity, competitive blocking capability, T cell activation effect, cytotoxic effector functions by Fc, preliminary an …
Nutrient Stress-Dysregulated Antisense lncRNA GLS-AS Impairs GLS-Mediated Metabolism and Represses Pancreatic Cancer Progression.
Deng SJ, Chen HY, Zeng Z, Deng S, Zhu S, Ye Z, He C, Liu ML, Huang K, Zhong JX, Xu FY, Li Q, Liu Y, Wang C, Zhao G. Deng SJ, et al. Cancer Res. 2019 Apr 1;79(7):1398-1412. doi: 10.1158/0008-5472.CAN-18-0419. Epub 2018 Dec 18. Cancer Res. 2019. PMID: 30563888
GLS-AS inhibited GLS expression at the posttranscriptional level via formation of double stranded RNA with GLS pre-mRNA through ADAR/Dicer-dependent RNA interference. ...Conversely, GLS-AS decreased Myc expression by impairing the GLS-mediated s …
GLS-AS inhibited GLS expression at the posttranscriptional level via formation of double stranded RNA with GLS pre-mRNA …
GLS loss of function causes autosomal recessive spastic ataxia and optic atrophy.
Lynch DS, Chelban V, Vandrovcova J, Pittman A, Wood NW, Houlden H. Lynch DS, et al. Ann Clin Transl Neurol. 2018 Jan 22;5(2):216-221. doi: 10.1002/acn3.522. eCollection 2018 Feb. Ann Clin Transl Neurol. 2018. PMID: 29468182 Free PMC article.
Through a combination of homozygosity mapping and whole-genome sequencing, we identified a homozygous copy number variant in GLS as the cause. The duplication leads to complete knockout of GLS expression. ...This is the first report implicating GLS loss of fu …
Through a combination of homozygosity mapping and whole-genome sequencing, we identified a homozygous copy number variant in GLS as t …
5,435 results