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Glucocorticoids suppress bone formation via the osteoclast.
Kim HJ, Zhao H, Kitaura H, Bhattacharyya S, Brewer JA, Muglia LJ, Ross FP, Teitelbaum SL. Kim HJ, et al. J Clin Invest. 2006 Aug;116(8):2152-60. doi: 10.1172/JCI28084. Epub 2006 Jul 27. J Clin Invest. 2006. PMID: 16878176 Free PMC article.
The pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear. For example, osteoblast apoptosis is enhanced by GCs in vivo, but they stimulate bone formation in vitro. ...Consistent with osteoclasts modulating the osteoblast-s …
The pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear. For example, osteoblast apoptosis is enhanced by …
Dexamethsone suppresses bone formation via the osteoclast.
Kim HJ, Zhao H, Kitaura H, Bhattacharyya S, Brewer JA, Muglia LJ, Ross FP, Teitelbaum SL. Kim HJ, et al. Adv Exp Med Biol. 2007;602:43-6. doi: 10.1007/978-0-387-72009-8_5. Adv Exp Med Biol. 2007. PMID: 17966386
This paradox raises the possibility that glucocorticoid suppression of bone formation, in vivo, reflects, at least in part, the steroid's targeting intermediary cells, which in turn inhibit the osteoblast. ...This process establishes that osteoclast …
This paradox raises the possibility that glucocorticoid suppression of bone formation, in vivo, reflects, at lea …
Glucocorticoid Signaling and Bone Biology.
Komori T. Komori T. Horm Metab Res. 2016 Nov;48(11):755-763. doi: 10.1055/s-0042-110571. Epub 2016 Nov 21. Horm Metab Res. 2016. PMID: 27871116 Review.
Glucocorticoid treatments impair bone formation and enhance bone resorption. Excess glucocorticoids induce osteoblast and osteocyte apoptosis by increasing pro-apoptotic molecules, reactive oxygen species, and endoplasmic reticulum stress and …
Glucocorticoid treatments impair bone formation and enhance bone resorption. Excess glucocorticoids induc …
Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head.
Yuan T, Wang H, Wang Y, Dong S, Ge J, Li Z, Sun S. Yuan T, et al. Mol Med. 2024 Jul 31;30(1):111. doi: 10.1186/s10020-024-00880-1. Mol Med. 2024. PMID: 39085816 Free PMC article.
BACKGROUND: Osteoclast hyperactivation due to the pathological overproduction of reactive oxygen species (ROS) stimulated by glucocorticoids (GCs) is one of the key drivers behind glucocorticoid-induced osteonecrosis of the femoral head (GIONFH). ...CONCLUSIO …
BACKGROUND: Osteoclast hyperactivation due to the pathological overproduction of reactive oxygen species (ROS) stimulated by gluco …
Methotrexate inhibits glucocorticoids-induced osteoclastogenesis via activating IFN-gammaR/STAT1 pathway in the treatment of rheumatoid arthritis.
Teng Y, Yin H, Feng R, Jiang L, Qiu W, Duan X, Wang X, Deng GM. Teng Y, et al. RMD Open. 2024 Nov 7;10(4):e004886. doi: 10.1136/rmdopen-2024-004886. RMD Open. 2024. PMID: 39510764 Free PMC article.
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by the synovitis and bone erosion. The combination therapy of glucocorticoids (GCs) and methotrexate (MTX) is recommended in early RA management, although the precise underlying mech …
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by the synovitis and bone erosion. The combinatio …
IL-6, IL-1beta, and TNF-alpha only in combination influence the osteoporotic phenotype in Crohn's patients via bone formation and bone resorption.
Blaschke M, Koepp R, Cortis J, Komrakova M, Schieker M, Hempel U, Siggelkow H. Blaschke M, et al. Adv Clin Exp Med. 2018 Jan;27(1):45-56. doi: 10.17219/acem/67561. Adv Clin Exp Med. 2018. PMID: 29521042 Free article.
In postmenopausal osteoporosis, bone resorption is induced by IL-6, IL-1beta and TNF-alpha. In contrast, in children with CD, IL-6 exclusively decreased bone formation without affecting bone resorption. OBJECTIVES: The objective of this study was to fu …
In postmenopausal osteoporosis, bone resorption is induced by IL-6, IL-1beta and TNF-alpha. In contrast, in children with CD, IL-6 ex …
Protein kinase G2 activation restores Wnt signaling and bone mass in glucocorticoid-induced osteoporosis in mice.
Pal China S, Kalyanaraman H, Zhuang S, Cabriales JA, Sah RL, Pilz RB. Pal China S, et al. JCI Insight. 2024 Jun 17;9(14):e175089. doi: 10.1172/jci.insight.175089. JCI Insight. 2024. PMID: 38885330 Free PMC article.
Osteoporotic fractures are a major complication of long-term glucocorticoid therapy. Glucocorticoids transiently increase bone resorption, but they predominantly inhibit bone formation and induce osteocyte apoptosis, leading to bone loss. …
Osteoporotic fractures are a major complication of long-term glucocorticoid therapy. Glucocorticoids transiently increase b …
The interaction between burn injury and vitamin D metabolism and consequences for the patient.
Klein GL. Klein GL. Curr Clin Pharmacol. 2008 Sep;3(3):204-10. doi: 10.2174/157488408785747647. Curr Clin Pharmacol. 2008. PMID: 18781907 Review.
The stress and inflammatory responses to burn injury are associated with bone loss. The stress response entails production of large amounts of endogenous glucocorticoids that decrease osteoblasts on the mineralization surface of bone and decreases differentia …
The stress and inflammatory responses to burn injury are associated with bone loss. The stress response entails production of large a …
Glucocorticoid receptors and bone.
La Corte R, Trotta F, Adami S. La Corte R, et al. Curr Pharm Des. 2010;16(32):3586-92. doi: 10.2174/138161210793797924. Curr Pharm Des. 2010. PMID: 20977422 Review.
The effects of GCs are - at least in part - mediated via specific GRs (genomic effect), however GCs also have acute non genomic effects. Osteoblasts are the most obvious target of GCs in bone, suppressing their maturation, activity and survival. Osteoblasts s …
The effects of GCs are - at least in part - mediated via specific GRs (genomic effect), however GCs also have acute non genomic effec …
Comparative study of holothurin A and echinoside A on inhibiting the high bone turnover via downregulating PI3K/AKT/beta-catenin and OPG/RANKL/NF-kappaB signaling in ovariectomized mice.
Yue H, Tian Y, Li Y, Bai X, Wang X, Wang Y, Li Z, Xue C, Wang J. Yue H, et al. Food Funct. 2022 Apr 20;13(8):4748-4756. doi: 10.1039/d1fo04357a. Food Funct. 2022. PMID: 35389397
The result showed that both HA and EA reduced the levels of serum osteogenesis markers ALP, collagen I, and OCN and bone resorption markers MMP-9, Cath-K and TRAP, and thus inhibited the high bone turnover induced by ovariectomy. ...CB1 and MKP-1 are the targ …
The result showed that both HA and EA reduced the levels of serum osteogenesis markers ALP, collagen I, and OCN and bone resor …
23 results