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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 3
1966 2
1967 2
1968 1
1969 7
1970 19
1971 14
1972 10
1973 13
1974 9
1975 10
1976 13
1977 12
1978 2
1979 8
1980 11
1981 8
1982 14
1983 11
1984 19
1985 11
1986 20
1987 17
1988 13
1989 27
1990 36
1991 31
1992 28
1993 41
1994 50
1995 36
1996 52
1997 59
1998 54
1999 65
2000 66
2001 43
2002 62
2003 58
2004 61
2005 59
2006 56
2007 65
2008 69
2009 76
2010 59
2011 56
2012 85
2013 76
2014 74
2015 79
2016 70
2017 79
2018 109
2019 92
2020 104
2021 106
2022 105
2023 95
2024 42

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2,373 results

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Page 1
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation.
Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Cruzat V, et al. Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564. Nutrients. 2018. PMID: 30360490 Free PMC article. Review.
In health and disease, the rate of glutamine consumption by immune cells is similar or greater than glucose. ...Therefore, this paper provides an integrated review of how glutamine metabolism in key organs is important to cells of the immune system …
In health and disease, the rate of glutamine consumption by immune cells is similar or greater than glucose. ...Therefore, thi …
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.
The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvironment of tumors. ...By contrast, effector T cells respon …
The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glu …
Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition.
Coqueiro AY, Rogero MM, Tirapegui J. Coqueiro AY, et al. Nutrients. 2019 Apr 17;11(4):863. doi: 10.3390/nu11040863. Nutrients. 2019. PMID: 30999561 Free PMC article. Review.
Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. ...Thus, this amino acid began to be investigated in sports nutrition beyond its effect on the immune system, attributing to …
Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. . …
Glutamine and the immune system.
Calder PC, Yaqoob P. Calder PC, et al. Amino Acids. 1999;17(3):227-41. doi: 10.1007/BF01366922. Amino Acids. 1999. PMID: 10582122 Review.
Glutamine is utilised at a high rate by cells of the immune system in culture and is required to support optimal lymphocyte proliferation and production of cytokines by lymphocytes and macrophages. ...The lowered plasma glutamine concentrations are mos …
Glutamine is utilised at a high rate by cells of the immune system in culture and is required to support optimal lympho …
The effect of glutamine supplementation on athletic performance, body composition, and immune function: A systematic review and a meta-analysis of clinical trials.
Ramezani Ahmadi A, Rayyani E, Bahreini M, Mansoori A. Ramezani Ahmadi A, et al. Clin Nutr. 2019 Jun;38(3):1076-1091. doi: 10.1016/j.clnu.2018.05.001. Epub 2018 May 9. Clin Nutr. 2019. PMID: 29784526
There was no association between glutamine ingestion and other outcomes investigated. CONCLUSION: According to this meta-analysis, generally, glutamine supplementation has no effect on athletics immune system, aerobic performance, and body composition. …
There was no association between glutamine ingestion and other outcomes investigated. CONCLUSION: According to this meta-analysis, ge …
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity.
Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, Sun X, Saravia J, Rankin S, Dhungana Y, Chi H. Guo C, et al. Nature. 2023 Aug;620(7972):200-208. doi: 10.1038/s41586-023-06299-8. Epub 2023 Jul 5. Nature. 2023. PMID: 37407815 Free PMC article.
Nutrient screening and integrative analyses show that glutamine is the dominant amino acid in promoting cDC1 function. Further, glutamine signalling via FLCN impinges on TFEB function. Loss of FLCN in DCs selectively impairs cDC1 function in vivo in a TFEB-dependent …
Nutrient screening and integrative analyses show that glutamine is the dominant amino acid in promoting cDC1 function. Further, gl …
Side effects of long-term glutamine supplementation.
Holecek M. Holecek M. JPEN J Parenter Enteral Nutr. 2013 Sep;37(5):607-16. doi: 10.1177/0148607112460682. Epub 2012 Sep 18. JPEN J Parenter Enteral Nutr. 2013. PMID: 22990615 Review.
Some people consume chronically glutamine (GLN) in high quantities (~40 g/d), although a number of biochemical pathways and cellular functions may be negatively affected. The following side effects of GLN supplementation are discussed: (1) Alterations in amino acid transpo …
Some people consume chronically glutamine (GLN) in high quantities (~40 g/d), although a number of biochemical pathways and cellular …
Side effects of amino acid supplements.
Holeček M. Holeček M. Physiol Res. 2022 Mar 25;71(1):29-45. doi: 10.33549/physiolres.934790. Epub 2022 Jan 19. Physiol Res. 2022. PMID: 35043647 Free PMC article.
In alphabetic order are examined arginine, beta-alanine, branched-chain amino acids, carnosine, citrulline, creatine, glutamine, histidine, beta -hydroxy- beta -methylbutyrate, leucine, and tryptophan. ...Further research is necessary to elucidate effects of high doses and …
In alphabetic order are examined arginine, beta-alanine, branched-chain amino acids, carnosine, citrulline, creatine, glutamine, hist …
Glutamine and the Tumor Immune Microenvironment.
Faiena I, Ueno D, Shuch B. Faiena I, et al. Eur Urol. 2019 May;75(5):764-765. doi: 10.1016/j.eururo.2019.01.015. Epub 2019 Jan 30. Eur Urol. 2019. PMID: 30711333 No abstract available.
CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions.
Liu PS, Chen YT, Li X, Hsueh PC, Tzeng SF, Chen H, Shi PZ, Xie X, Parik S, Planque M, Fendt SM, Ho PC. Liu PS, et al. Nat Immunol. 2023 Mar;24(3):452-462. doi: 10.1038/s41590-023-01430-3. Epub 2023 Feb 23. Nat Immunol. 2023. PMID: 36823405 Free PMC article.
Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of pro-inflammatory genes and anti-tumorigenic phenotypes in macrophages. Mechanistically, glutamine usage …
Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent …
2,373 results