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Glycyrrhizin as a promising kryptonite against SARS-CoV-2: Clinical, experimental, and theoretical evidences.
Banerjee S, Baidya SK, Adhikari N, Ghosh B, Jha T. Banerjee S, et al. J Mol Struct. 2023 Mar 5;1275:134642. doi: 10.1016/j.molstruc.2022.134642. Epub 2022 Nov 25. J Mol Struct. 2023. PMID: 36467615 Free PMC article. Review.
This systematic review highlights the detailed therapeutic implication of naturally occurring glycyrrhizin and its related derivatives against COVID-19. Glycyrrhizin has already been established for blocking different biomolecular targets related to the SARS- …
This systematic review highlights the detailed therapeutic implication of naturally occurring glycyrrhizin and its related derivative …
Glycyrrhizin Inhibits SARS-CoV-2 Entry into Cells by Targeting ACE2.
He MF, Liang JH, Shen YN, Zhang JW, Liu Y, Yang KY, Liu LC, Wang J, Xie Q, Hu C, Song X, Wang Y. He MF, et al. Life (Basel). 2022 Oct 26;12(11):1706. doi: 10.3390/life12111706. Life (Basel). 2022. PMID: 36362861 Free PMC article.
Glycyrrhizin inhibited the binding of the spike protein of the SARS-CoV-2 to ACE2 in our Western blot-based assay. ...Together, we believe that glycyrrhizin inhibits SARS-CoV-2 entry into cells by targeting ACE2....
Glycyrrhizin inhibited the binding of the spike protein of the SARS-CoV-2 to ACE2 in our Western blot-based assa …
Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease.
van de Sand L, Bormann M, Alt M, Schipper L, Heilingloh CS, Steinmann E, Todt D, Dittmer U, Elsner C, Witzke O, Krawczyk A. van de Sand L, et al. Viruses. 2021 Apr 2;13(4):609. doi: 10.3390/v13040609. Viruses. 2021. PMID: 33918301 Free PMC article.
The outbreak of SARS-CoV-2 developed into a global pandemic affecting millions of people worldwide. ...Natural products with antiviral activity may contribute to improve the overall condition of SARS-CoV-2 infected individuals. In the pre …
The outbreak of SARS-CoV-2 developed into a global pandemic affecting millions of people worldwide. ...Natural products …
Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication.
Gowda P, Patrick S, Joshi SD, Kumawat RK, Sen E. Gowda P, et al. Cytokine. 2021 Jun;142:155496. doi: 10.1016/j.cyto.2021.155496. Epub 2021 Mar 12. Cytokine. 2021. PMID: 33773396 Free PMC article.
Heightened release of proinflammatory cytokines IL-1beta, IL-6 and IL-8, as well as ferritin from macrophages cultured in conditioned media from lung cells expressing SARS-CoV-2 S-RBD and Orf3a was attenuated by glycyrrhizin. Importantly, Glycyrrhiz …
Heightened release of proinflammatory cytokines IL-1beta, IL-6 and IL-8, as well as ferritin from macrophages cultured in conditioned media …
Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2.
Ahmad S, Waheed Y, Abro A, Abbasi SW, Ismail S. Ahmad S, et al. J Mol Model. 2021 Jun 24;27(7):206. doi: 10.1007/s00894-021-04816-y. J Mol Model. 2021. PMID: 34169390 Free PMC article.
The interaction between SARS-CoV-2 Spike protein and angiotensin-converting enzyme 2 (ACE2) is essential to viral attachment and the subsequent fusion process. ...Here, a hybrid approach of ligand- and structure-based virtual screening techniques were employe …
The interaction between SARS-CoV-2 Spike protein and angiotensin-converting enzyme 2 (ACE2) is essential to viral attac …
Phytochemicals in the Prevention and Treatment of SARS-CoV-2-Clinical Evidence.
Bijelić K, Hitl M, Kladar N. Bijelić K, et al. Antibiotics (Basel). 2022 Nov 13;11(11):1614. doi: 10.3390/antibiotics11111614. Antibiotics (Basel). 2022. PMID: 36421257 Free PMC article. Review.
The first case of SARS-CoV-2 infection was reported in December 2019. Due to the rapid spread of the disease and the lack of adequate therapy, the use of plants that have a long history in the treatment of viral infections has often been considered. ...Numero …
The first case of SARS-CoV-2 infection was reported in December 2019. Due to the rapid spread of the disease and the la …
Antiviral activity of medicinal plant-derived products against SARS-CoV-2.
de Oliveira JR, Antunes BS, do Nascimento GO, Kawall JCS, Oliveira JVB, Silva KGDS, Costa MAT, Oliveira CR. de Oliveira JR, et al. Exp Biol Med (Maywood). 2022 Oct;247(20):1797-1809. doi: 10.1177/15353702221108915. Epub 2022 Jul 27. Exp Biol Med (Maywood). 2022. PMID: 35894129 Free PMC article. Review.
These plant products have been shown to impede the adsorption of SARS-CoV-2 to the host cell, and prevent multiplication of the virus post its entry into the host cell. In addition to antiviral activity, the plant products have also been demonstrated to exert …
These plant products have been shown to impede the adsorption of SARS-CoV-2 to the host cell, and prevent multiplicatio …
The anti-SARS-CoV-2 effect and mechanism of Chiehyuan herbal oral protection solution.
Wu CY, Yang YH, Lin YS, Shu LH, Cheng YC, Liu HT, Lin YY, Lee IY, Shih WT, Yang PR, Tsai YY, Chang GH, Hsu CM, Yeh RA, Wu YH, Wu YH, Shen RC, Tsai MS. Wu CY, et al. Heliyon. 2023 Jul 3;9(7):e17701. doi: 10.1016/j.heliyon.2023.e17701. eCollection 2023 Jul. Heliyon. 2023. PMID: 37483781 Free PMC article.
Glycyrrhizic acid, a major compound in GB-2, also hindered the entry of the Omicron variant (BA.1) of the SARS-CoV-2 pseudotyped lentivirus by obstructing the binding between ACE2 and the RBD presenting the N501Y-K417N-E484A-G339D-Q493R-G496S-Q4 …
Glycyrrhizic acid, a major compound in GB-2, also hindered the entry of the Omicron variant (BA.1) of the SARS-CoV …
Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses.
Fomenko VV, Rudometova NB, Yarovaya OI, Rogachev AD, Fando AA, Zaykovskaya AV, Komarova NI, Shcherbakov DN, Pyankov OV, Pokrovsky AG, Karpenko LI, Maksyutov RA, Salakhutdinov NF. Fomenko VV, et al. Molecules. 2022 Jan 4;27(1):295. doi: 10.3390/molecules27010295. Molecules. 2022. PMID: 35011529 Free PMC article.
When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co-morbidities. ...The composition of Glycyvir was characterized by HPLC-MS/MS and its toxicity assessed in cell culture. Antiviral activity a …
When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co …
Molecular docking, molecular dynamics simulation and MM-GBSA studies of the activity of glycyrrhizin relevant substructures on SARS-CoV-2 RNA-dependent-RNA polymerase.
Zamzami MA. Zamzami MA. J Biomol Struct Dyn. 2023 Mar;41(5):1846-1858. doi: 10.1080/07391102.2021.2025147. Epub 2022 Jan 17. J Biomol Struct Dyn. 2023. PMID: 35037842
SARS-CoV-2 is the causative agent of Coronavirus Disease (COVID-19), which is a life-threatening disease. ...To counteract the recurrence of the severe acute respiratory syndrome, active antiviral medications are urgently required. Glycyrrhizin was doc …
SARS-CoV-2 is the causative agent of Coronavirus Disease (COVID-19), which is a life-threatening disease. ...To counter …
111 results