Gobeil SMC - Search Results

1

¹⁵N, ¹³C and ¹H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus.

Gobeil SMC, Bobay BG, Spicer LD, Venters RA. Gobeil SMC, et al. Biomol NMR Assign. 2019 Apr;13(1):207-212. doi: 10.1007/s12104-019-09878-x. Epub 2019 Feb 1. Biomol NMR Assign. 2019. PMID: 30707421 Free PMC article.

2

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.

Juvvadi PR, Fox D 3rd, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Juvvadi PR, et al. Among authors: gobeil smc. Nat Commun. 2019 Sep 19;10(1):4275. doi: 10.1038/s41467-019-12199-1. Nat Commun. 2019. PMID: 31537789 Free PMC article.

3

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.

Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. Juvvadi PR, et al. Among authors: gobeil smc. Biochem Biophys Res Commun. 2020 May 21;526(1):48-54. doi: 10.1016/j.bbrc.2020.03.062. Epub 2020 Mar 16. Biochem Biophys Res Commun. 2020. PMID: 32192767 Free PMC article.

4

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.

Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Gobeil SM, et al. mBio. 2021 Dec 21;12(6):e0300021. doi: 10.1128/mBio.03000-21. Epub 2021 Nov 23. mBio. 2021. PMID: 34809463 Free PMC article.

5

15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant.

Gobeil SM, Gagné D, Doucet N, Pelletier JN. Gobeil SM, et al. Biomol NMR Assign. 2016 Apr;10(1):93-9. doi: 10.1007/s12104-015-9645-8. Epub 2015 Sep 19. Biomol NMR Assign. 2016. PMID: 26386961 Free PMC article.

6

Backbone resonance assignments of an artificially engineered TEM-1/PSE-4 Class A β-lactamase chimera.

Morin S, Clouthier CM, Gobeil S, Pelletier JN, Gagné SM. Morin S, et al. Biomol NMR Assign. 2010 Oct;4(2):127-30. doi: 10.1007/s12104-010-9227-8. Epub 2010 Apr 10. Biomol NMR Assign. 2010. PMID: 20383614

7

Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions.

Clouthier CM, Morin S, Gobeil SM, Doucet N, Blanchet J, Nguyen E, Gagné SM, Pelletier JN. Clouthier CM, et al. PLoS One. 2012;7(12):e52283. doi: 10.1371/journal.pone.0052283. Epub 2012 Dec 21. PLoS One. 2012. PMID: 23284969 Free PMC article.

8

Maintenance of native-like protein dynamics may not be required for engineering functional proteins.

Gobeil SMC, Clouthier CM, Park J, Gagné D, Berghuis AM, Doucet N, Pelletier JN. Gobeil SMC, et al. Chem Biol. 2014 Oct 23;21(10):1330-1340. doi: 10.1016/j.chembiol.2014.07.016. Epub 2014 Sep 4. Chem Biol. 2014. PMID: 25200606

9

The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.

Gobeil SMC, Ebert MCCJC, Park J, Gagné D, Doucet N, Berghuis AM, Pleiss J, Pelletier JN. Gobeil SMC, et al. Sci Rep. 2019 Apr 30;9(1):6656. doi: 10.1038/s41598-019-42866-8. Sci Rep. 2019. PMID: 31040324 Free PMC article.

10

Development of sulfahydantoin derivatives as β-lactamase inhibitors.

Paquet-Côté PA, Alejaldre L, Lapointe Verreault C, Gobeil SMC, Lamoureux R, Bédard L, Normandeau CO, Lemay-St-Denis C, Pelletier JN, Voyer N. Paquet-Côté PA, et al. Among authors: gobeil smc. Bioorg Med Chem Lett. 2021 Mar 1;35:127781. doi: 10.1016/j.bmcl.2021.127781. Epub 2021 Jan 8. Bioorg Med Chem Lett. 2021. PMID: 33422604

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