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Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.
Mhlekude B, Postmus D, Stenzel S, Weiner J 3rd, Jansen J, Zapatero-Belinchón FJ, Olmer R, Richter A, Heinze J, Heinemann N, Mühlemann B, Schroeder S, Jones TC, Müller MA, Drosten C, Pich A, Thiel V, Martin U, Niemeyer D, Gerold G, Beule D, Goffinet C. Mhlekude B, et al. Among authors: goffinet c. PLoS Pathog. 2023 Sep 25;19(9):e1011657. doi: 10.1371/journal.ppat.1011657. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37747932 Free PMC article.
Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses.
Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voss Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G. Uckeley ZM, et al. Among authors: goffinet c. Mol Cell Proteomics. 2019 Dec;18(12):2401-2417. doi: 10.1074/mcp.RA119.001631. Epub 2019 Sep 30. Mol Cell Proteomics. 2019. PMID: 31570497 Free PMC article.
Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics.
Schroeder S, Pott F, Niemeyer D, Veith T, Richter A, Muth D, Goffinet C, Müller MA, Drosten C. Schroeder S, et al. Among authors: goffinet c. Lancet Microbe. 2021 May;2(5):e210-e218. doi: 10.1016/S2666-5247(21)00027-6. Epub 2021 Mar 4. Lancet Microbe. 2021. PMID: 33969329 Free PMC article.
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction.
Franz S, Pott F, Zillinger T, Schüler C, Dapa S, Fischer C, Passos V, Stenzel S, Chen F, Döhner K, Hartmann G, Sodeik B, Pessler F, Simmons G, Drexler JF, Goffinet C. Franz S, et al. Among authors: goffinet c. Life Sci Alliance. 2021 Jun 2;4(7):e202000909. doi: 10.26508/lsa.202000909. Print 2021 Jul. Life Sci Alliance. 2021. PMID: 34078739 Free PMC article.
A realistic transfer method reveals low risk of SARS-CoV-2 transmission via contaminated euro coins and banknotes.
Todt D, Meister TL, Tamele B, Howes J, Paulmann D, Becker B, Brill FH, Wind M, Schijven J, Heinen N, Kinast V, Mhlekude B, Goffinet C, Krawczyk A, Steinmann J, Pfaender S, Brüggemann Y, Steinmann E. Todt D, et al. Among authors: goffinet c. iScience. 2021 Aug 20;24(8):102908. doi: 10.1016/j.isci.2021.102908. Epub 2021 Jul 26. iScience. 2021. PMID: 34337354 Free PMC article.
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M. Nouailles G, et al. Among authors: goffinet c. Nat Commun. 2021 Aug 11;12(1):4869. doi: 10.1038/s41467-021-25030-7. Nat Commun. 2021. PMID: 34381043 Free PMC article.
Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott F, Postmus D, Brown RJP, Wyler E, Neumann E, Landthaler M, Goffinet C. Pott F, et al. Among authors: goffinet c. Emerg Microbes Infect. 2021 Dec;10(1):2151-2168. doi: 10.1080/22221751.2021.2000891. Emerg Microbes Infect. 2021. PMID: 34723780 Free PMC article.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI); Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. Wendisch D, et al. Among authors: goffinet c. Cell. 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27. Cell. 2021. PMID: 34914922 Free PMC article.
79 results