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Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Wang H, Yu N, Chen D, Lee KC, Lye PL, Chang JW, Deng W, Ng MC, Lu T, Khoo ML, Poulsen A, Sangthongpitag K, Wu X, Hu C, Goh KC, Wang X, Fang L, Goh KL, Khng HH, Goh SK, Yeo P, Liu X, Bonday Z, Wood JM, Dymock BW, Kantharaj E, Sun ET. Wang H, et al. Among authors: goh kc, goh sk, goh kl. J Med Chem. 2011 Jul 14;54(13):4694-720. doi: 10.1021/jm2003552. Epub 2011 Jun 16. J Med Chem. 2011. PMID: 21634430
Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors.
Blanchard S, William AD, Lee AC, Poulsen A, Teo EL, Deng W, Tu N, Tan E, Goh KL, Ong WC, Ng CP, Goh KC, Bonday Z, Sun ET. Blanchard S, et al. Among authors: goh kc, goh kl. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2443-7. doi: 10.1016/j.bmcl.2010.03.018. Epub 2010 Mar 7. Bioorg Med Chem Lett. 2010. PMID: 20338758
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Blanchard S, Soh CK, Lee CP, Poulsen A, Bonday Z, Goh KL, Goh KC, Goh MK, Pasha MK, Wang H, Williams M, Wood JM, Ethirajulu K, Dymock BW. Blanchard S, et al. Among authors: goh mk, goh kc, goh kl. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2880-4. doi: 10.1016/j.bmcl.2012.02.058. Epub 2012 Feb 27. Bioorg Med Chem Lett. 2012. PMID: 22437109
Structure-based design of Aurora A & B inhibitors.
Poulsen A, William A, Lee A, Blanchard S, Teo E, Deng W, Tu N, Tan E, Sun E, Goh KL, Ong WC, Ng CP, Goh KC, Bonday Z. Poulsen A, et al. Among authors: goh kc, goh kl. J Comput Aided Mol Des. 2008 Dec;22(12):897-906. doi: 10.1007/s10822-008-9224-5. Epub 2008 Jun 24. J Comput Aided Mol Des. 2008. PMID: 18574696
511 results