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Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat.
Toxicology. 2007 Oct 30;240(1-2):70-85. doi: 10.1016/j.tox.2007.07.018. Epub 2007 Aug 1.
Toxicology. 2007.
PMID: 17804142
Influence of mustard group structure on pathways of in vitro metabolism of anticancer N-(2-hydroxyethyl)-3,5-dinitrobenzamide 2-mustard prodrugs.
Helsby NA, Goldthorpe MA, Tang MH, Atwell GJ, Smith EM, Wilson WR, Tingle MD.
Helsby NA, et al. Among authors: goldthorpe ma.
Drug Metab Dispos. 2008 Feb;36(2):353-60. doi: 10.1124/dmd.107.018739. Epub 2007 Nov 12.
Drug Metab Dispos. 2008.
PMID: 17998296
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The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation.
Helsby NA, Hui CY, Goldthorpe MA, Coller JK, Soh MC, Gow PJ, De Zoysa JZ, Tingle MD.
Helsby NA, et al. Among authors: goldthorpe ma.
Br J Clin Pharmacol. 2010 Dec;70(6):844-53. doi: 10.1111/j.1365-2125.2010.03789.x.
Br J Clin Pharmacol. 2010.
PMID: 21175440
Free PMC article.
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Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans?
Helsby N, Goldthorpe M, Gow P, de Zoysa J.
Helsby N, et al.
N Z Med J. 2010 May 28;123(1315):37-41.
N Z Med J. 2010.
PMID: 20581929
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CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity.
Burns KE, Goldthorpe MA, Porteus F, Browett P, Helsby NA.
Burns KE, et al. Among authors: goldthorpe ma.
Cancer Chemother Pharmacol. 2014 Mar;73(3):651-5. doi: 10.1007/s00280-014-2409-9. Epub 2014 Feb 12.
Cancer Chemother Pharmacol. 2014.
PMID: 24519754
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Antitumour action of 5,6-dimethylxanthenone-4-acetic acid in rats bearing chemically induced primary mammary tumours.
Liu JJ, Ching LM, Goldthorpe M, Sutherland R, Baguley BC, Kirker JA, McKeage MJ.
Liu JJ, et al.
Cancer Chemother Pharmacol. 2007 Apr;59(5):661-9. doi: 10.1007/s00280-006-0321-7. Epub 2006 Aug 31.
Cancer Chemother Pharmacol. 2007.
PMID: 16944150
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