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Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins.
Wang H, Hu L, Dalen K, Dorward H, Marcinkiewicz A, Russell D, Gong D, Londos C, Yamaguchi T, Holm C, Rizzo MA, Brasaemle D, Sztalryd C. Wang H, et al. Among authors: gong d. J Biol Chem. 2009 Nov 13;284(46):32116-25. doi: 10.1074/jbc.M109.006726. Epub 2009 Aug 29. J Biol Chem. 2009. PMID: 19717842 Free PMC article.
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.
Albert JS, Yerges-Armstrong LM, Horenstein RB, Pollin TI, Sreenivasan UT, Chai S, Blaner WS, Snitker S, O'Connell JR, Gong DW, Breyer RJ 3rd, Ryan AS, McLenithan JC, Shuldiner AR, Sztalryd C, Damcott CM. Albert JS, et al. N Engl J Med. 2014 Jun 12;370(24):2307-2315. doi: 10.1056/NEJMoa1315496. Epub 2014 May 21. N Engl J Med. 2014. PMID: 24848981 Free PMC article.
1,720 results