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Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.
González-Martínez J, Cwetsch AW, Martínez-Alonso D, López-Sainz LR, Almagro J, Melati A, Gómez J, Pérez-Martínez M, Megías D, Boskovic J, Gilabert-Juan J, Graña-Castro O, Pierani A, Behrens A, Ortega S, Malumbres M. González-Martínez J, et al. JCI Insight. 2021 Aug 23;6(16):e146364. doi: 10.1172/jci.insight.146364. JCI Insight. 2021. PMID: 34237032 Free PMC article.
Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division.
González-Martínez J, Cwetsch AW, Gilabert-Juan J, Gómez J, Garaulet G, Schneider P, de Cárcer G, Mulero F, Caleiras E, Megías D, Porlan E, Malumbres M. González-Martínez J, et al. Cell Death Differ. 2022 Aug;29(8):1474-1485. doi: 10.1038/s41418-022-00937-w. Epub 2022 Jan 20. Cell Death Differ. 2022. PMID: 35058575 Free PMC article.
Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
Villarroya-Beltri C, Martins AFB, García A, Giménez D, Zarzuela E, Novo M, Del Álamo C, González-Martínez J, Bonel-Pérez GC, Díaz I, Guillamot M, Chiesa M, Losada A, Graña-Castro O, Rovira M, Muñoz J, Salazar-Roa M, Malumbres M. Villarroya-Beltri C, et al. EMBO J. 2023 Jan 4;42(1):e111251. doi: 10.15252/embj.2022111251. Epub 2022 Nov 3. EMBO J. 2023. PMID: 36326833 Free PMC article.
The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. Sanz-Castillo B, et al. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. EMBO J. 2023. PMID: 36354735 Free PMC article.
Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells.
López-Valero I, Dávila D, González-Martínez J, Salvador-Tormo N, Lorente M, Saiz-Ladera C, Torres S, Gabicagogeascoa E, Hernández-Tiedra S, García-Taboada E, Mendiburu-Eliçabe M, Rodríguez-Fornés F, Sánchez-Domínguez R, Segovia JC, Sánchez-Gómez P, Matheu A, Sepúlveda JM, Velasco G. López-Valero I, et al. Theranostics. 2020 Apr 6;10(11):5120-5136. doi: 10.7150/thno.41450. eCollection 2020. Theranostics. 2020. PMID: 32308772 Free PMC article.
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.
Hernández-Tiedra S, Fabriàs G, Dávila D, Salanueva ÍJ, Casas J, Montes LR, Antón Z, García-Taboada E, Salazar-Roa M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, Serrano-Puebla A, García-López R, González-Martínez J, Abad JL, Hanada K, Boya P, Goñi F, Guzmán M, Lovat P, Jäättelä M, Alonso A, Velasco G. Hernández-Tiedra S, et al. Autophagy. 2016 Nov;12(11):2213-2229. doi: 10.1080/15548627.2016.1213927. Epub 2016 Sep 16. Autophagy. 2016. PMID: 27635674 Free PMC article.
373 results