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Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.
Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27.
Diabetes. 2011.
PMID: 20980460
Free PMC article.
Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass.
Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A.
Roccisana J, et al. Among authors: gonzalez pertusa ja.
Diabetes. 2005 Jul;54(7):2090-102. doi: 10.2337/diabetes.54.7.2090.
Diabetes. 2005.
PMID: 15983210
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Growth factors and beta cell replication.
Vasavada RC, Gonzalez-Pertusa JA, Fujinaka Y, Fiaschi-Taesch N, Cozar-Castellano I, Garcia-Ocaña A.
Vasavada RC, et al. Among authors: gonzalez pertusa ja.
Int J Biochem Cell Biol. 2006;38(5-6):931-50. doi: 10.1016/j.biocel.2005.08.003. Epub 2005 Aug 31.
Int J Biochem Cell Biol. 2006.
PMID: 16168703
Review.
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Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis.
González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A.
González-Pertusa JA, et al.
Endocrinology. 2010 Apr;151(4):1487-98. doi: 10.1210/en.2009-0975. Epub 2010 Feb 22.
Endocrinology. 2010.
PMID: 20176723
Free PMC article.
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