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Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase.
Bioorg Med Chem. 1997 Sep;5(9):1831-8. doi: 10.1016/s0968-0896(97)00121-1.
Bioorg Med Chem. 1997.
PMID: 9354238
No abstract available.
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
Marsilje TH, et al. Among authors: gooljarsingh lt.
Bioorg Med Chem. 2002 Aug;10(8):2739-49. doi: 10.1016/s0968-0896(02)00102-5.
Bioorg Med Chem. 2002.
PMID: 12057663
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Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.
Boger DL, Kochanny MJ, Cai H, Wyatt D, Kitos PA, Warren MS, Ramcharan J, Gooljarsingh LT, Benkovic SJ.
Boger DL, et al. Among authors: gooljarsingh lt.
Bioorg Med Chem. 1998 Jun;6(6):643-59. doi: 10.1016/s0968-0896(98)00040-6.
Bioorg Med Chem. 1998.
PMID: 9681131
No abstract available.
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Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA.
Zhang Y, et al. Among authors: gooljarsingh lt.
Biochemistry. 2003 May 27;42(20):6043-56. doi: 10.1021/bi034219c.
Biochemistry. 2003.
PMID: 12755606
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Localization of GAR transformylase in Escherichia coli and mammalian cells.
Gooljarsingh LT, Ramcharan J, Gilroy S, Benkovic SJ.
Gooljarsingh LT, et al.
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6565-70. doi: 10.1073/pnas.121182998. Epub 2001 May 29.
Proc Natl Acad Sci U S A. 2001.
PMID: 11381136
Free PMC article.
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A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.
Gooljarsingh LT, Fernandes C, Yan K, Zhang H, Grooms M, Johanson K, Sinnamon RH, Kirkpatrick RB, Kerrigan J, Lewis T, Arnone M, King AJ, Lai Z, Copeland RA, Tummino PJ.
Gooljarsingh LT, et al.
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7625-30. doi: 10.1073/pnas.0602650103. Epub 2006 May 9.
Proc Natl Acad Sci U S A. 2006.
PMID: 16684877
Free PMC article.
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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.
Gooljarsingh LT, Lakdawala A, Coppo F, Luo L, Fields GB, Tummino PJ, Gontarek RR.
Gooljarsingh LT, et al.
Protein Sci. 2008 Jan;17(1):66-71. doi: 10.1110/ps.073130208. Epub 2007 Nov 27.
Protein Sci. 2008.
PMID: 18042679
Free PMC article.
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