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17-β Estradiol regulates proglucagon-derived peptide secretion in mouse and human α- and L cells.
Handgraaf S, Dusaulcy R, Visentin F, Philippe J, Gosmain Y. Handgraaf S, et al. Among authors: gosmain y. JCI Insight. 2018 Apr 5;3(7):e98569. doi: 10.1172/jci.insight.98569. eCollection 2018 Apr 5. JCI Insight. 2018. PMID: 29618657 Free PMC article.
Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.
Katz LS, Gosmain Y, Marthinet E, Philippe J. Katz LS, et al. Among authors: gosmain y. Mol Cell Biol. 2009 Apr;29(8):2322-34. doi: 10.1128/MCB.01543-08. Epub 2009 Feb 17. Mol Cell Biol. 2009. PMID: 19223471 Free PMC article.
The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6.
Gauthier BR, Gosmain Y, Mamin A, Philippe J. Gauthier BR, et al. Among authors: gosmain y. Biochem J. 2007 May 1;403(3):593-601. doi: 10.1042/BJ20070053. Biochem J. 2007. PMID: 17263687 Free PMC article.
Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.
Gosmain Y, Avril I, Mamin A, Philippe J. Gosmain Y, et al. J Biol Chem. 2007 Nov 30;282(48):35024-34. doi: 10.1074/jbc.M702795200. Epub 2007 Sep 27. J Biol Chem. 2007. PMID: 17901057
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function.
Gosmain Y, Marthinet E, Cheyssac C, Guérardel A, Mamin A, Katz LS, Bouzakri K, Philippe J. Gosmain Y, et al. J Biol Chem. 2010 Oct 22;285(43):33381-93. doi: 10.1074/jbc.M110.147215. Epub 2010 Jun 30. J Biol Chem. 2010. PMID: 20592023 Free PMC article.
Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.
Gosmain Y, Cheyssac C, Heddad Masson M, Dibner C, Philippe J. Gosmain Y, et al. Diabetes Obes Metab. 2011 Oct;13 Suppl 1:31-8. doi: 10.1111/j.1463-1326.2011.01445.x. Diabetes Obes Metab. 2011. PMID: 21824254 Review.
Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion.
Gosmain Y, Katz LS, Masson MH, Cheyssac C, Poisson C, Philippe J. Gosmain Y, et al. Mol Endocrinol. 2012 Apr;26(4):696-709. doi: 10.1210/me.2011-1256. Epub 2012 Mar 8. Mol Endocrinol. 2012. PMID: 22403172 Free PMC article.
Pax6 is a key component of regulated glucagon secretion.
Gosmain Y, Cheyssac C, Masson MH, Guérardel A, Poisson C, Philippe J. Gosmain Y, et al. Endocrinology. 2012 Sep;153(9):4204-15. doi: 10.1210/en.2012-1425. Epub 2012 Jul 9. Endocrinology. 2012. PMID: 22778220
Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion.
Heddad Masson M, Poisson C, Guérardel A, Mamin A, Philippe J, Gosmain Y. Heddad Masson M, et al. Among authors: gosmain y. Endocrinology. 2014 Oct;155(10):3781-92. doi: 10.1210/en.2013-1843. Epub 2014 Jul 24. Endocrinology. 2014. PMID: 25057789
α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin.
Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. Dusaulcy R, et al. Among authors: gosmain y. Endocrinology. 2016 Feb;157(2):536-47. doi: 10.1210/en.2015-1725. Epub 2015 Dec 22. Endocrinology. 2016. PMID: 26696123 Free PMC article.
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