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Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.
Tyner JW, Yang WF, Bankhead A 3rd, Fan G, Fletcher LB, Bryant J, Glover JM, Chang BH, Spurgeon SE, Fleming WH, Kovacsovics T, Gotlib JR, Oh ST, Deininger MW, Zwaan CM, Den Boer ML, van den Heuvel-Eibrink MM, O'Hare T, Druker BJ, Loriaux MM. Tyner JW, et al. Among authors: gotlib jr. Cancer Res. 2013 Jan 1;73(1):285-96. doi: 10.1158/0008-5472.CAN-12-1906. Epub 2012 Oct 18. Cancer Res. 2013. PMID: 23087056 Free PMC article.
RNAi screen for rapid therapeutic target identification in leukemia patients.
Tyner JW, Deininger MW, Loriaux MM, Chang BH, Gotlib JR, Willis SG, Erickson H, Kovacsovics T, O'Hare T, Heinrich MC, Druker BJ. Tyner JW, et al. Among authors: gotlib jr. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8695-700. doi: 10.1073/pnas.0903233106. Epub 2009 May 11. Proc Natl Acad Sci U S A. 2009. PMID: 19433805 Free PMC article.
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.
Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW. Maxson JE, et al. N Engl J Med. 2013 May 9;368(19):1781-90. doi: 10.1056/NEJMoa1214514. N Engl J Med. 2013. PMID: 23656643 Free PMC article.
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, Weigert O, Kopp N, Wu SC, Kim SS, Liu H, Tivey T, Christie AL, Elpek KG, Card J, Gritsman K, Gotlib J, Deininger MW, Makishima H, Turley SJ, Javidi-Sharifi N, Maciejewski JP, Jaiswal S, Ebert BL, Rodig SJ, Tyner JW, Marto JA, Weinstock DM, Lane AA. Yoda A, et al. Nat Med. 2015 Jan;21(1):71-5. doi: 10.1038/nm.3751. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485910 Free PMC article.
Genomic landscape of neutrophilic leukemias of ambiguous diagnosis.
Zhang H, Wilmot B, Bottomly D, Dao KT, Stevens E, Eide CA, Khanna V, Rofelty A, Savage S, Reister Schultz A, Long N, White L, Carlos A, Henson R, Lin C, Searles R, Collins RH, DeAngelo DJ, Deininger MW, Dunn T, Hein T, Luskin MR, Medeiros BC, Oh ST, Pollyea DA, Steensma DP, Stone RM, Druker BJ, McWeeney SK, Maxson JE, Gotlib JR, Tyner JW. Zhang H, et al. Among authors: gotlib jr. Blood. 2019 Sep 12;134(11):867-879. doi: 10.1182/blood.2019000611. Epub 2019 Jul 31. Blood. 2019. PMID: 31366621 Free PMC article.
234 results