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GPR108 is required for gambogic acid inhibiting NF-kappaB signaling in cancer.
Lyu S, Zhang X, Tu Z, Zhou H, Ke X, Qu Y. Lyu S, et al. Pharmacol Res. 2022 Aug;182:106279. doi: 10.1016/j.phrs.2022.106279. Epub 2022 Jun 2. Pharmacol Res. 2022. PMID: 35659621
Depletion of GPR108 dramatically inhibited the survival of various cancers. Notably, TNFalpha activation of NF-kappaB was totally impaired after GPR108 knockout. We identified gambogic acid (GA), a natural prenylated xanthone, selectively targeting GPR108. Im …
Depletion of GPR108 dramatically inhibited the survival of various cancers. Notably, TNFalpha activation of NF-kappaB was totally imp …
GPR108 Is a Highly Conserved AAV Entry Factor.
Dudek AM, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, Franceschini JS, Estelien R, Carette JE, Zhou GL, Vandenberghe LH. Dudek AM, et al. Mol Ther. 2020 Feb 5;28(2):367-381. doi: 10.1016/j.ymthe.2019.11.005. Epub 2019 Nov 13. Mol Ther. 2020. PMID: 31784416 Free PMC article.
Of greater than 20 divergent AAVs across all AAV clades tested in human cell lines, only AAV5 transduction was unaffected in the GPR108 knockout (KO). GPR108 dependency was further shown in murine and primary cells in vitro. ...Mechanistically, both GPR108 N- …
Of greater than 20 divergent AAVs across all AAV clades tested in human cell lines, only AAV5 transduction was unaffected in the GPR108 …
A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
Zhao M, Zhang Y, Qiang L, Lu Z, Zhao Z, Fu Y, Wu B, Chai Q, Ge P, Lei Z, Zhang X, Li B, Wang J, Zhang L, Liu CH. Zhao M, et al. Cell Rep. 2023 Jun 27;42(6):112655. doi: 10.1016/j.celrep.2023.112655. Epub 2023 Jun 17. Cell Rep. 2023. PMID: 37330913 Free article.
Here, we identify the Golgi-localized G protein-coupled receptor 108 (GPR108) as a regulator of type iota interferon responses by targeting interferon regulatory factor 3 (IRF3). ...Taken together, our study provides insight into the crosstalk between the Golgi apparatus a …
Here, we identify the Golgi-localized G protein-coupled receptor 108 (GPR108) as a regulator of type iota interferon responses by tar …
GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
Dong D, Zhou H, Na SY, Niedra R, Peng Y, Wang H, Seed B, Zhou GL. Dong D, et al. PLoS One. 2018 Oct 17;13(10):e0205303. doi: 10.1371/journal.pone.0205303. eCollection 2018. PLoS One. 2018. PMID: 30332431 Free PMC article.
Co-expression of TLRs and GPR108 reduces NF-kappaB and IFNbeta promoter activation compared to expression of either TLRs or GPR108 alone. ...In turn GPR108 is antagonized by TIRAP, an adaptor protein for TLR and MyD88. ...
Co-expression of TLRs and GPR108 reduces NF-kappaB and IFNbeta promoter activation compared to expression of either TLRs or GPR108 …
Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.
Hoel CM, Zhang L, Brohawn SG. Hoel CM, et al. Elife. 2022 Nov 14;11:e81704. doi: 10.7554/eLife.81704. Elife. 2022. PMID: 36373655 Free PMC article.
We find TMEM87A shares its characteristic domain arrangement with seven other proteins in humans; three that had been identified as evolutionary related (TMEM87B, GPR107, and GPR108) and four previously unrecognized homologs (GPR180, TMEM145, TMEM181, and WLS). ...
We find TMEM87A shares its characteristic domain arrangement with seven other proteins in humans; three that had been identified as evolutio …
Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction.
Meisen WH, Nejad ZB, Hardy M, Zhao H, Oliverio O, Wang S, Hale C, Ollmann MM, Collins PJ. Meisen WH, et al. Mol Ther Methods Clin Dev. 2020 Mar 17;17:601-611. doi: 10.1016/j.omtm.2020.03.012. eCollection 2020 Jun 12. Mol Ther Methods Clin Dev. 2020. PMID: 32280726 Free PMC article.
In addition to KIAA0319L (AAVR), we confirmed the role of two genes, GPR108 and TM9SF2, in mediating viral transduction in eight different AAV serotypes. Interestingly, GPR108 displayed serotype selectivity and was not required for AAV5 transduction. ...
In addition to KIAA0319L (AAVR), we confirmed the role of two genes, GPR108 and TM9SF2, in mediating viral transduction in eight diff …
Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry.
Smith TJ, Fusco RM, Elmore ZC, Asokan A. Smith TJ, et al. J Virol. 2023 May 31;97(5):e0009323. doi: 10.1128/jvi.00093-23. Epub 2023 Apr 25. J Virol. 2023. PMID: 37097176 Free PMC article.
Recombinant furin does not cleave AAV4 capsid proteins nor alter cellular expression levels of essential factors such as AAVR or GPR108. Interestingly, fluorescent lectin screening revealed a marked increase in 2,3-O-linked sialoglycan staining on the surface and perinucle …
Recombinant furin does not cleave AAV4 capsid proteins nor alter cellular expression levels of essential factors such as AAVR or GPR108 …
Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors.
Edgar AJ. Edgar AJ. DNA Seq. 2007 Jun;18(3):235-41. doi: 10.1080/10425170701207182. DNA Seq. 2007. PMID: 17454009
Two new cDNAs, human GPR107 and murine GPR108, were cloned from mammalian lung that are members of a novel gene family encoding proteins that are predicted to have an amino-terminal hydrophobic signal peptide sequence, a long extracellular domain and a carboxy-terminal sev …
Two new cDNAs, human GPR107 and murine GPR108, were cloned from mammalian lung that are members of a novel gene family encoding prote …
Himasthla elongata: effect of infection on expression of the LUSTR-like receptor mRNA in common periwinkle haemocytes.
Gorbushin AM, Klimovich AV, Iakovleva NV. Gorbushin AM, et al. Exp Parasitol. 2009 Sep;123(1):24-30. doi: 10.1016/j.exppara.2009.05.004. Epub 2009 May 19. Exp Parasitol. 2009. PMID: 19460375
The first mollusc mRNA coding G-protein-coupled transmembrane receptor (GPcapital ES, CyrillicR), homologous to human receptors LUSTR 1 (GPR107) and LUSTR 2 (GPR108), was isolated from haemocytes of common periwinkle Littorina littorea. ...
The first mollusc mRNA coding G-protein-coupled transmembrane receptor (GPcapital ES, CyrillicR), homologous to human receptors LUSTR 1 (GPR …
Identification and characterization of human FNBP1L gene in silico.
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2004 Jan;13(1):157-62. Int J Mol Med. 2004. PMID: 14654988
FNBP1L-SH2D3B locus at human chromosome 1p22.1 was paralogous to GPR108-TRIP10-SH2D3A locus at 19p13.3 and GPR107-FNBP1-SH2D3C locus at 9q34.11-q34.13. ...
FNBP1L-SH2D3B locus at human chromosome 1p22.1 was paralogous to GPR108-TRIP10-SH2D3A locus at 19p13.3 and GPR107-FNBP1-SH2D3C locus …