Grütter MG - Search Results

1

Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.

Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grütter MG, Powers JC. Ekici OD, et al. Among authors: grutter mg. J Med Chem. 2006 Sep 21;49(19):5728-49. doi: 10.1021/jm0601405. J Med Chem. 2006. PMID: 16970398

2

Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors.

Ganesan R, Jelakovic S, Campbell AJ, Li ZZ, Asgian JL, Powers JC, Grütter MG. Ganesan R, et al. Among authors: grutter mg. Biochemistry. 2006 Aug 1;45(30):9059-67. doi: 10.1021/bi060364p. Biochemistry. 2006. PMID: 16866351

3

In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety.

Ganesan R, Jelakovic S, Mittl PR, Caflisch A, Grütter MG. Ganesan R, et al. Among authors: grutter mg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):842-50. doi: 10.1107/S1744309111018604. Epub 2011 Jul 13. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21821879 Free PMC article.

4

Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis.

Ganesan R, Mittl PR, Jelakovic S, Grütter MG. Ganesan R, et al. Among authors: grutter mg. J Mol Biol. 2006 Jun 23;359(5):1378-88. doi: 10.1016/j.jmb.2006.04.051. Epub 2006 May 11. J Mol Biol. 2006. PMID: 16787777

5

Human caspases in vitro: expression, purification and kinetic characterization.

Roschitzki-Voser H, Schroeder T, Lenherr ED, Frölich F, Schweizer A, Donepudi M, Ganesan R, Mittl PR, Baici A, Grütter MG. Roschitzki-Voser H, et al. Among authors: grutter mg. Protein Expr Purif. 2012 Aug;84(2):236-46. doi: 10.1016/j.pep.2012.05.009. Epub 2012 Jun 7. Protein Expr Purif. 2012. PMID: 22683476

6

Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.

Schweizer A, Briand C, Grutter MG. Schweizer A, et al. Among authors: grutter mg. J Biol Chem. 2003 Oct 24;278(43):42441-7. doi: 10.1074/jbc.M304895200. Epub 2003 Aug 14. J Biol Chem. 2003. PMID: 12920126 Free article.

7

Structure and zymogen activation of caspases.

Donepudi M, Grütter MG. Donepudi M, et al. Among authors: grutter mg. Biophys Chem. 2002 Dec 10;101-102:145-53. doi: 10.1016/s0301-4622(02)00151-5. Biophys Chem. 2002. PMID: 12487996 Review.

8

HIV-1 protease inhibition potential of functionalized polyoxometalates.

Flütsch A, Schroeder T, Grütter MG, Patzke GR. Flütsch A, et al. Among authors: grutter mg. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1162-6. doi: 10.1016/j.bmcl.2010.12.103. Epub 2010 Dec 25. Bioorg Med Chem Lett. 2011. PMID: 21256010 Free PMC article.

9

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.

Rahuel J, Rasetti V, Maibaum J, Rüeger H, Göschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grütter MG. Rahuel J, et al. Among authors: grutter mg. Chem Biol. 2000 Jul;7(7):493-504. doi: 10.1016/s1074-5521(00)00134-4. Chem Biol. 2000. PMID: 10903938

10

Specific targeting of human caspases using designed ankyrin repeat proteins.

Flütsch A, Schroeder T, Barandun J, Ackermann R, Bühlmann M, Grütter MG. Flütsch A, et al. Among authors: grutter mg. Biol Chem. 2014 Oct;395(10):1243-52. doi: 10.1515/hsz-2014-0173. Biol Chem. 2014. PMID: 25153593 Free article.

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