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Page 1
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.
Ng MYW, Charsou C, Lapao A, Singh S, Trachsel-Moncho L, Schultz SW, Nakken S, Munson MJ, Simonsen A. Ng MYW, et al. Nat Commun. 2022 Oct 21;13(1):6283. doi: 10.1038/s41467-022-33933-2. Nat Commun. 2022. PMID: 36270994 Free PMC article.
We further show that the ER-localized cholesterol transport protein GRAMD1C functions as a negative regulator of starvation-induced autophagy and that both its cholesterol transport VASt domain and membrane binding GRAM domain are required for GRAMD1C-mediated suppr …
We further show that the ER-localized cholesterol transport protein GRAMD1C functions as a negative regulator of starvation-induced a …
Reduced GRAMD1C expression correlates to poor prognosis and immune infiltrates in kidney renal clear cell carcinoma.
Hao H, Wang Z, Ren S, Shen H, Xian H, Ge W, Wang W. Hao H, et al. PeerJ. 2019 Dec 20;7:e8205. doi: 10.7717/peerj.8205. eCollection 2019. PeerJ. 2019. PMID: 31875150 Free PMC article.
Using bioinformatics methods, we judged the prognostic value of GRAMD1C expression in KIRC and investigated the underlying mechanisms of GRAMD1C affecting the overall survival of KIRC based on data downloaded from The Cancer Genome Atlas (TCGA). ...Thus, GRAMD1C …
Using bioinformatics methods, we judged the prognostic value of GRAMD1C expression in KIRC and investigated the underlying mechanisms …
Regulation of autophagosome biogenesis and mitochondrial bioenergetics by the cholesterol transport protein GRAMD1C.
Charsou C, Ng MYW, Simonsen A. Charsou C, et al. Autophagy. 2023 Jul;19(7):2159-2161. doi: 10.1080/15548627.2022.2155020. Epub 2022 Dec 12. Autophagy. 2023. PMID: 36469687 Free PMC article.
In our study, we demonstrate that short term cholesterol depletion leads to a rapid induction of autophagy and identify the ER-localized cholesterol transport protein GRAMD1C as a negative regulator of starvation-induced macroautophagy/autophagy. ...
In our study, we demonstrate that short term cholesterol depletion leads to a rapid induction of autophagy and identify the ER-localized cho …
Knocking down GRAMD1C expression reduces 6-OHDA-induced apoptosis in PC12 cells.
He H, Zhang B, Wang X, Chen L. He H, et al. Toxicol Res (Camb). 2024 Apr 17;13(2):tfae051. doi: 10.1093/toxres/tfae051. eCollection 2024 Apr. Toxicol Res (Camb). 2024. PMID: 38638451
Furthermore, GRAMD1C was notably enhanced in the PD patients and 6-OHDA-induced PC12 cells. Besides, 6-OHDA stimulation significantly reduced PC12 cell proliferation, and it reverted with the GRAMD1C siRNA. Moreover, the flow cytometry results showed that knockdown …
Furthermore, GRAMD1C was notably enhanced in the PD patients and 6-OHDA-induced PC12 cells. Besides, 6-OHDA stimulation significantly …
Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites.
Naito T, Yang H, Koh DHZ, Mahajan D, Lu L, Saheki Y. Naito T, et al. Nat Commun. 2023 Sep 21;14(1):5867. doi: 10.1038/s41467-023-41213-w. Nat Commun. 2023. PMID: 37735529 Free PMC article.
Here, we show that lipid transfer proteins, namely ORP9, OSBP, and GRAMD1s/Asters (GRAMD1a/GRAMD1b/GRAMD1c), control non-vesicular cholesterol transport at points of contact between the ER and the trans-Golgi network (TGN), thereby maintaining cellular cholesterol distribu …
Here, we show that lipid transfer proteins, namely ORP9, OSBP, and GRAMD1s/Asters (GRAMD1a/GRAMD1b/GRAMD1c), control non-vesicular ch …
Potential Common Molecular Mechanisms Between Periodontitis and Hepatocellular Carcinoma: A Bioinformatic Analysis and Validation.
Fan X, Song Z, Qin W, Yu T, Peng B, Shen Y. Fan X, et al. Cancer Genomics Proteomics. 2023 Nov-Dec;20(6):602-616. doi: 10.21873/cgp.20409. Cancer Genomics Proteomics. 2023. PMID: 37889061 Free PMC article.
LASSO, random forest algorithm and SVM-RFE showed the diagnostic significance of DE mRNAs in HCC. Cox regression analyses revealed that MSH2, GRAMD1C and CTHRC1 have prognostic significance for HCC, and qRT-PCR and IHC validated this finding. CONCLUSION: Periodontitis may …
LASSO, random forest algorithm and SVM-RFE showed the diagnostic significance of DE mRNAs in HCC. Cox regression analyses revealed that MSH2 …
Development and Validation of a Novel Prognosis Model Based on a Panel of Three Immunogenic Cell Death-Related Genes for Non-Cirrhotic Hepatocellular Carcinoma.
Gong J, Yu R, Hu X, Luo H, Gao Q, Li Y, Tan G, Luo H, Qin B. Gong J, et al. J Hepatocell Carcinoma. 2023 Sep 25;10:1609-1628. doi: 10.2147/JHC.S424545. eCollection 2023. J Hepatocell Carcinoma. 2023. PMID: 37781718 Free PMC article.
RESULTS: Cox regression analyses were performed to construct a prognostic risk score model comprising three genes (TMC7, GRAMD1C, and GNPDA1) based on DEGs between two clusters. The model stratified patients with NCHCC into two risk groups. ...In vitro functional validatio …
RESULTS: Cox regression analyses were performed to construct a prognostic risk score model comprising three genes (TMC7, GRAMD1C, and …
The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance.
Banerjee R, Hohe RC, Cao S, Jung BM, Horak AJ, Ramachandiran I, Massey WJ, Varadharajan V, Zajczenko NI, Burrows AC, Dutta S, Goudarzi M, Mahen K, Carter A, Helsley RN, Gordon SM, Morton RE, Strauch C, Willard B, Gogonea CB, Gogonea V, Pedrelli M, Parini P, Brown JM. Banerjee R, et al. Front Physiol. 2024 Apr 17;15:1371096. doi: 10.3389/fphys.2024.1371096. eCollection 2024. Front Physiol. 2024. PMID: 38694206 Free PMC article.
Here, we have examined whole body cholesterol balance in mice globally lacking Aster-C under low or high dietary cholesterol conditions. METHOD: Age-matched Gramd1c (+/+) and Gramd1c (-/-) mice were fed either low (0.02%, wt/wt) or high (0.2%, wt/wt) dietarycholeste …
Here, we have examined whole body cholesterol balance in mice globally lacking Aster-C under low or high dietary cholesterol conditions. MET …
A cholesterogenic gene signature for predicting the prognosis of young breast cancer patients.
Li X, Zhou C, Qiu C, Li W, Yu Q, Huang H, Zhang Y, Zhang X, Ren L, Huang X, Zhou Q. Li X, et al. PeerJ. 2022 Aug 18;10:e13922. doi: 10.7717/peerj.13922. eCollection 2022. PeerJ. 2022. PMID: 35999846 Free PMC article.
A risk scoring signature contained five cholesterogenic genes (risk score = -1.169 GRAMD1C -0.992 NFKBIA + 0.432 INHBA + 0.261 CD24 -0.839 ACSS2) was established, which could differentiate the prognosis of young BC patients between high-risk and low-risk group (<0.001). …
A risk scoring signature contained five cholesterogenic genes (risk score = -1.169 GRAMD1C -0.992 NFKBIA + 0.432 INHBA + 0.261 CD24 - …
Identification of a Four-Gene Signature for Diagnosing Paediatric Sepsis.
Yao Y, Zhao J, Hu J, Song H, Wang S, Wang Y. Yao Y, et al. Biomed Res Int. 2022 Feb 14;2022:5217885. doi: 10.1155/2022/5217885. eCollection 2022. Biomed Res Int. 2022. PMID: 35198634 Free PMC article. Retracted.
RESULTS: A total of 41 CGs were selected from the GSE119217 dataset. A four-gene signature composed of ANXA3, CD177, GRAMD1C, and TIGD3 effectively distinguished patients with paediatric sepsis from those in the control group. ...
RESULTS: A total of 41 CGs were selected from the GSE119217 dataset. A four-gene signature composed of ANXA3, CD177, GRAMD1C, and TIG …
15 results