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GRAMD2 (+) alveolar type I cell plasticity facilitates cell state transitions in organoid culture.
Shen H, Chen W, Liu Y, Castaldi A, Castillo J, Horie M, Flodby P, Sundar S, Li C, Ji Y, Minoo P, Marconett CN, Zhou B, Borok Z. Shen H, et al. bioRxiv [Preprint]. 2023 Oct 18:2023.10.17.560801. doi: 10.1101/2023.10.17.560801. bioRxiv. 2023. PMID: 37905051 Free PMC article. Preprint.
Interestingly, Gramd2 (CreERT2) GFP (+) cells were able to form organoids in organoid co-culture with Mlg fibroblasts. ...Our results indicate that Gramd2 (+) AT1 cells are highly plastic suggesting they may contribute to alveolar regeneration....
Interestingly, Gramd2 (CreERT2) GFP (+) cells were able to form organoids in organoid co-culture with Mlg fibroblasts. ...Our results …
Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma.
Yang M, Shen H, Flodby P, Koss MD, Bassiouni R, Liu Y, Jashashvili T, Neely A, Ogbolu E, Castillo J, Stueve TR, Mullen DJ, Ryan AL, Carpten J, Castaldi A, Wallace WD, Zhou B, Borok Z, Marconett CN. Yang M, et al. Cell Rep. 2023 Dec 26;42(12):113286. doi: 10.1016/j.celrep.2023.113286. Epub 2023 Nov 22. Cell Rep. 2023. PMID: 37995179 Free PMC article.
Here, we examine oncogenic transformation in mouse Gram-domain containing 2 (Gramd2)(+) AT1 cells via oncogenic KRAS(G12D). Activation of KRAS(G12D) in AT1 cells induces multifocal LUAD, primarily of papillary histology. Furthermore, KRT8(+) intermediate cell states were o …
Here, we examine oncogenic transformation in mouse Gram-domain containing 2 (Gramd2)(+) AT1 cells via oncogenic KRAS(G12D). Activatio …
Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.
Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z. Marconett CN, et al. Am J Respir Cell Mol Biol. 2017 Mar;56(3):310-321. doi: 10.1165/rcmb.2016-0071OC. Am J Respir Cell Mol Biol. 2017. PMID: 27749084 Free PMC article.
Testing the top four candidate genes at RNA and protein levels revealed GRAM domain 2 (GRAMD2), a protein of unknown function, as highly specific to AT1 cells. RNA sequencing (RNAseq) confirmed that GRAMD2 is transcriptionally silent in human AT2 cells. Immunofluore …
Testing the top four candidate genes at RNA and protein levels revealed GRAM domain 2 (GRAMD2), a protein of unknown function, as hig …
Maternal fatty acid concentrations and newborn DNA methylation.
Robinson SL, Mumford SL, Guan W, Zeng X, Kim K, Radoc JG, Trinh MH, Flannagan K, Schisterman EF, Yeung E. Robinson SL, et al. Am J Clin Nutr. 2020 Mar 1;111(3):613-621. doi: 10.1093/ajcn/nqz311. Am J Clin Nutr. 2020. PMID: 31858113 Free PMC article. Clinical Trial.
Preconception marine PUFA concentration was associated with higher methylation at GRAMD2 (P = 1.1 10-8), LOXL1 (P = 5.5 10-8), SIK3 (P = 1.6 10-7), HTR1B (P = 1.9 10-7), and MCC (P = 2.1 10-7) genes. ...
Preconception marine PUFA concentration was associated with higher methylation at GRAMD2 (P = 1.1 10-8), LOXL1 (P = 5.5 10-8), SIK3 ( …
Molecular Changes in the Non-Inflamed Terminal Ileum of Patients with Ulcerative Colitis.
Lee HS, Vancamelbeke M, Verstockt S, Wilms T, Verstockt B, Sabino J, Ferrante M, Vermeire S, Cleynen I. Lee HS, et al. Cells. 2020 Jul 28;9(8):1793. doi: 10.3390/cells9081793. Cells. 2020. PMID: 32731480 Free PMC article.
We found 84 dysregulated genes in patients with active extensive colitis and 20 in inactive extensive colitis, compared to controls. There was an overlap of 5 genes: REG1B, REG1A, MUC4, GRAMD2, and CASP10. In patients with left-sided colitis, ileal gene expression levels w …
We found 84 dysregulated genes in patients with active extensive colitis and 20 in inactive extensive colitis, compared to controls. There w …
Genome-wide copy number variation analysis in a Chinese autism spectrum disorder cohort.
Guo H, Peng Y, Hu Z, Li Y, Xun G, Ou J, Sun L, Xiong Z, Liu Y, Wang T, Chen J, Xia L, Bai T, Shen Y, Tian Q, Hu Y, Shen L, Zhao R, Zhang X, Zhang F, Zhao J, Zou X, Xia K. Guo H, et al. Sci Rep. 2017 Mar 10;7:44155. doi: 10.1038/srep44155. Sci Rep. 2017. PMID: 28281572 Free PMC article. Clinical Trial.
The de novo 15q11-13 duplication was more prevalent in this Chinese population than in those with European ancestry. Several genes, including GRAMD2 and STAM, were implicated as novel ASD risk genes when integrating whole-genome CNVs and whole-exome sequencing data. ...
The de novo 15q11-13 duplication was more prevalent in this Chinese population than in those with European ancestry. Several genes, includin …
Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling.
Lkhagvadorj K, Zeng Z, Song J, Reinders-Luinge M, Kooistra W, Song S, Krauss-Etschmann S, Melgert BN, Cao J, Hylkema MN. Lkhagvadorj K, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L742-L751. doi: 10.1152/ajplung.00209.2020. Epub 2020 Aug 12. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32783621 Free article.
Moreover, prenatally smoke-exposed offspring had higher numbers of alveolar epithelial type II cells (AECII) and lower expression of the AECI-related Pdpn and Gramd2 markers. This was accompanied by higher expression of Areg and lower expression of Egf in prenatally smoke- …
Moreover, prenatally smoke-exposed offspring had higher numbers of alveolar epithelial type II cells (AECII) and lower expression of the AEC …