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5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans.
Rabiner EA, Wilkins MR, Turkheimer F, Gunn RN, Udo de Haes J, de Vries M, Grasby PM. Rabiner EA, et al. Among authors: grasby pm. J Pharmacol Exp Ther. 2002 Jun;301(3):1144-50. doi: 10.1124/jpet.301.3.1144. J Pharmacol Exp Ther. 2002. PMID: 12023549
Occupancy of agonist drugs at the 5-HT1A receptor.
Bantick RA, Rabiner EA, Hirani E, de Vries MH, Hume SP, Grasby PM. Bantick RA, et al. Among authors: grasby pm. Neuropsychopharmacology. 2004 May;29(5):847-59. doi: 10.1038/sj.npp.1300390. Neuropsychopharmacology. 2004. PMID: 14985704
Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET.
Osman S, Lundkvist C, Pike VW, Halldin C, McCarron JA, Swahn CG, Ginovart N, Luthra SK, Bench CJ, Grasby PM, Wikström H, Barf T, Cliffe IA, Fletcher A, Farde L. Osman S, et al. Among authors: grasby pm. Nucl Med Biol. 1996 Jul;23(5):627-34. doi: 10.1016/0969-8051(96)00061-3. Nucl Med Biol. 1996. PMID: 8905828
Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635--explanation of high signal contrast in PET and an aid to biomathematical modelling.
Osman S, Lundkvist C, Pike VW, Halldin C, McCarron JA, Swahn CG, Farde L, Ginovart N, Luthra SK, Gunn RN, Bench CJ, Sargent PA, Grasby PM. Osman S, et al. Among authors: grasby pm. Nucl Med Biol. 1998 Apr;25(3):215-23. doi: 10.1016/s0969-8051(97)00206-0. Nucl Med Biol. 1998. PMID: 9620626
122 results