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Page 1
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation.
Shinzawa K, Matsumoto S, Sada R, Harada A, Saitoh K, Kato K, Ikeda S, Hirayama A, Yokoi K, Tanemura A, Nimura K, Ikawa M, Soga T, Kikuchi A. Shinzawa K, et al. Oncogene. 2023 Oct;42(42):3142-3156. doi: 10.1038/s41388-023-02803-6. Epub 2023 Sep 1. Oncogene. 2023. PMID: 37658191 Free PMC article.
In this study, we found that a GREB1 splicing variant, isoform 4 (Is4), which encodes C-terminal half of full-length GREB1, is specifically expressed via microphthalmia-associated transcription factor (MITF) in melanocytic melanoma, and that two MITF-binding E-box C …
In this study, we found that a GREB1 splicing variant, isoform 4 (Is4), which encodes C-terminal half of full-length GREB1, is …
GREB1 regulates PI3K/Akt signaling to control hormone-sensitive breast cancer proliferation.
Haines CN, Klingensmith HD, Komara M, Burd CJ. Haines CN, et al. Carcinogenesis. 2020 Dec 31;41(12):1660-1670. doi: 10.1093/carcin/bgaa096. Carcinogenesis. 2020. PMID: 32894276 Free PMC article.
Herein, we validate that knockdown of GREB1 results in growth arrest and that exogenous GREB1 expression initiates senescence, suggesting that an optimal level of GREB1 expression is necessary for proliferation of breast cancer cells. Under both of these cond …
Herein, we validate that knockdown of GREB1 results in growth arrest and that exogenous GREB1 expression initiates senescence, …
Wnt Signaling Stimulates Cooperation between GREB1 and HNF4alpha to Promote Proliferation in Hepatocellular Carcinoma.
Matsumoto S, Harada A, Seta M, Akita M, Gon H, Fukumoto T, Kikuchi A. Matsumoto S, et al. Cancer Res. 2023 Jul 14;83(14):2312-2327. doi: 10.1158/0008-5472.CAN-22-3518. Cancer Res. 2023. PMID: 37347203
To elucidate the unique mode of Wnt signaling in HCC, we comprehensively investigated HCC-specific Wnt pathway target genes and identified GREB1. Wnt signaling induced expression of GREB1 coupled with HNF4alpha and FOXA2, master transcription factors that maintain h …
To elucidate the unique mode of Wnt signaling in HCC, we comprehensively investigated HCC-specific Wnt pathway target genes and identified …
Uterine mesenchymal tumours: recent advances.
Momeni-Boroujeni A, Chiang S. Momeni-Boroujeni A, et al. Histopathology. 2020 Jan;76(1):64-75. doi: 10.1111/his.14008. Histopathology. 2020. PMID: 31846533 Review.
Some uterine tumours resembling ovarian sex-cord tumour harbour GREB1 and ESR1 rearrangements. Histological and immunophenotypical features as well as underlying genetic abnormalities defining these lesions are discussed....
Some uterine tumours resembling ovarian sex-cord tumour harbour GREB1 and ESR1 rearrangements. Histological and immunophenotypical fe …
Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers.
Cheng M, Michalski S, Kommagani R. Cheng M, et al. Int J Mol Sci. 2018 Aug 28;19(9):2543. doi: 10.3390/ijms19092543. Int J Mol Sci. 2018. PMID: 30154312 Free PMC article. Review.
Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1). GREB1 is an early estrogen-responsive gene, and its expression is correlated with estrogen levels in breast cancer patients …
Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GR …
GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer.
Liu M, Wang G, Gomez-Fernandez CR, Guo S. Liu M, et al. PLoS One. 2012;7(10):e46410. doi: 10.1371/journal.pone.0046410. Epub 2012 Oct 3. PLoS One. 2012. PMID: 23056300 Free PMC article. Retracted.
METHODS: We overexpressed GREB1 using adenovirus containing the full length GREB1 cDNA (Ad-GREB1) in breast cancer cell lines. ...E2 treatment increased GREB1 promoter luciferase activity. IL-6 inhibited E2-induced GREB1 transcription activity a …
METHODS: We overexpressed GREB1 using adenovirus containing the full length GREB1 cDNA (Ad-GREB1) in breast cancer cell …
Consideration of GREB1 as a potential therapeutic target for hormone-responsive or endocrine-resistant cancers.
Hodgkinson KM, Vanderhyden BC. Hodgkinson KM, et al. Expert Opin Ther Targets. 2014 Sep;18(9):1065-76. doi: 10.1517/14728222.2014.936382. Epub 2014 Jul 5. Expert Opin Ther Targets. 2014. PMID: 24998469 Review.
AREAS COVERED: This review examines growing evidence for the important role played by the steroid hormone-induced gene called GREB1, or growth regulation by estrogen in breast cancer 1. GREB1 is a critical mediator of both the estrogen-stimulated proliferation of br …
AREAS COVERED: This review examines growing evidence for the important role played by the steroid hormone-induced gene called GREB1, …
Greb1 Transiently Accelerates Pancreatic beta-Cell Proliferation in Diabetic Mice Exposed to Estradiol.
Inada A, Yasunami Y, Yoshiki A, Nabeshima YI, Inada O. Inada A, et al. Am J Pathol. 2023 Aug;193(8):1081-1100. doi: 10.1016/j.ajpath.2023.04.012. Am J Pathol. 2023. PMID: 37516458
To substantiate this, beta-cell-specific Greb1-deficient mice were generated, and Greb1 was shown to be essential for recovery of depleted beta cells in diabetic mice. ...Greb1 expression due to a drastic increase in exogenous or endogenous E2 was transient a …
To substantiate this, beta-cell-specific Greb1-deficient mice were generated, and Greb1 was shown to be essential for recovery …
GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERalpha glycosylation and stability to cancer.
Shin EM, Huynh VT, Neja SA, Liu CY, Raju A, Tan K, Tan NS, Gunaratne J, Bi X, Iyer LM, Aravind L, Tergaonkar V. Shin EM, et al. Sci Adv. 2021 Mar 17;7(12):eabe2470. doi: 10.1126/sciadv.abe2470. Print 2021 Mar. Sci Adv. 2021. PMID: 33731348 Free PMC article.
Loss of GREB1-mediated glycosylation of ERalpha results in reduced cellular ERalpha levels and insensitivity to estrogen. ...Mice lacking Greb1 exhibit growth and fertility defects reminiscent of phenotypes in ERalpha-null mice. ...
Loss of GREB1-mediated glycosylation of ERalpha results in reduced cellular ERalpha levels and insensitivity to estrogen. ...Mice lac …
greb1 regulates convergent extension movement and pituitary development in zebrafish.
Li SZ, Liu W, Li Z, Li WH, Wang Y, Zhou L, Gui JF. Li SZ, et al. Gene. 2017 Sep 5;627:176-187. doi: 10.1016/j.gene.2017.06.016. Epub 2017 Jun 9. Gene. 2017. PMID: 28606834
However, the role of greb1 in development is largely unknown. In this study, we have characterized greb1 expression patterns and revealed its regulative role in convergent extension movement and pituitary development in zebrafish. In zebrafish adults, greb1 w …
However, the role of greb1 in development is largely unknown. In this study, we have characterized greb1 expression patterns a …
227 results