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Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.
Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J. Bhatia S, et al. Among authors: grez m. Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. Epub 2018 May 3. Blood. 2018. PMID: 29724897 Free PMC article.
Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity.
Wichmann C, Becker Y, Chen-Wichmann L, Vogel V, Vojtkova A, Herglotz J, Moore S, Koch J, Lausen J, Mäntele W, Gohlke H, Grez M. Wichmann C, et al. Among authors: grez m. Blood. 2010 Jul 29;116(4):603-13. doi: 10.1182/blood-2009-10-248047. Epub 2010 Apr 29. Blood. 2010. PMID: 20430957 Free article.
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice.
Weber H, Leal P, Stein S, Kunkel H, García P, Bizama C, Espinoza JA, Riquelme I, Nervi B, Araya JC, Grez M, Roa JC. Weber H, et al. Among authors: grez m. Oncotarget. 2015 Oct 13;6(31):31877-88. doi: 10.18632/oncotarget.5047. Oncotarget. 2015. PMID: 26397134 Free PMC article.
Acetylation of Stat1 modulates NF-kappaB activity.
Krämer OH, Baus D, Knauer SK, Stein S, Jäger E, Stauber RH, Grez M, Pfitzner E, Heinzel T. Krämer OH, et al. Among authors: grez m. Genes Dev. 2006 Feb 15;20(4):473-85. doi: 10.1101/gad.364306. Genes Dev. 2006. PMID: 16481475 Free PMC article.
140 results