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TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. Ye L, et al. Among authors: griffin pr. Cell. 2012 Sep 28;151(1):96-110. doi: 10.1016/j.cell.2012.08.034. Cell. 2012. PMID: 23021218 Free PMC article.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Choi JH, et al. Among authors: griffin pr. Nature. 2010 Jul 22;466(7305):451-6. doi: 10.1038/nature09291. Nature. 2010. PMID: 20651683 Free PMC article.
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR. Choi JH, et al. Among authors: griffin pr. Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383. Nature. 2011. PMID: 21892191 Free PMC article.
Identification of SR2211: a potent synthetic RORγ-selective modulator.
Kumar N, Lyda B, Chang MR, Lauer JL, Solt LA, Burris TP, Kamenecka TM, Griffin PR. Kumar N, et al. Among authors: griffin pr. ACS Chem Biol. 2012 Apr 20;7(4):672-7. doi: 10.1021/cb200496y. Epub 2012 Feb 13. ACS Chem Biol. 2012. PMID: 22292739 Free PMC article.
Antiobesity Effect of a Small Molecule Repressor of RORγ.
Chang MR, He Y, Khan TM, Kuruvilla DS, Garcia-Ordonez R, Corzo CA, Unger TJ, White DW, Khan S, Lin L, Cameron MD, Kamenecka TM, Griffin PR. Chang MR, et al. Among authors: griffin pr. Mol Pharmacol. 2015 Jul;88(1):48-56. doi: 10.1124/mol.114.097485. Epub 2015 Apr 22. Mol Pharmacol. 2015. PMID: 25904554 Free PMC article.
279 results