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Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy.
Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Danièle N, Martin S, Rivière C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Guan X, Goddard M, Mitchell E, Barber J, Williams JK, Mack DL, Furth ME, Vignaud A, Masurier C, Mavilio F, Moullier P, Beggs AH, Buj-Bello A. Childers MK, et al. Among authors: guan x. Sci Transl Med. 2014 Jan 22;6(220):220ra10. doi: 10.1126/scitranslmed.3007523. Sci Transl Med. 2014. PMID: 24452262 Free PMC article.
Gene therapy in monogenic congenital myopathies.
Guan X, Goddard MA, Mack DL, Childers MK. Guan X, et al. Methods. 2016 Apr 15;99:91-8. doi: 10.1016/j.ymeth.2015.10.004. Epub 2015 Oct 14. Methods. 2016. PMID: 26454198 Free PMC article. Review.
Muscle function in a canine model of X-linked myotubular myopathy.
Grange RW, Doering J, Mitchell E, Holder MN, Guan X, Goddard M, Tegeler C, Beggs AH, Childers MK. Grange RW, et al. Among authors: guan x. Muscle Nerve. 2012 Oct;46(4):588-91. doi: 10.1002/mus.23463. Muscle Nerve. 2012. PMID: 22987702 Free PMC article.
Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery.
Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Guan X, et al. Stem Cell Res. 2014 Mar;12(2):467-80. doi: 10.1016/j.scr.2013.12.004. Epub 2013 Dec 23. Stem Cell Res. 2014. PMID: 24434629 Free PMC article.
Absence of full-length dystrophin impairs normal maturation and contraction of cardiomyocytes derived from human-induced pluripotent stem cells.
Pioner JM, Guan X, Klaiman JM, Racca AW, Pabon L, Muskheli V, Macadangdang J, Ferrantini C, Hoopmann MR, Moritz RL, Kim DH, Tesi C, Poggesi C, Murry CE, Childers MK, Mack DL, Regnier M. Pioner JM, et al. Among authors: guan x. Cardiovasc Res. 2020 Feb 1;116(2):368-382. doi: 10.1093/cvr/cvz109. Cardiovasc Res. 2020. PMID: 31049579 Free PMC article.
Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Pioner JM, Racca AW, Klaiman JM, Yang KC, Guan X, Pabon L, Muskheli V, Zaunbrecher R, Macadangdang J, Jeong MY, Mack DL, Childers MK, Kim DH, Tesi C, Poggesi C, Murry CE, Regnier M. Pioner JM, et al. Among authors: guan x. Stem Cell Reports. 2016 Jun 14;6(6):885-896. doi: 10.1016/j.stemcr.2016.04.006. Epub 2016 May 5. Stem Cell Reports. 2016. PMID: 27161364 Free PMC article.
6,019 results