Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy.
Guerrero-Valero M, Grandi F, Cipriani S, Alberizzi V, Di Guardo R, Chicanne G, Sawade L, Bianchi F, Del Carro U, De Curtis I, Pareyson D, Parman Y, Schenone A, Haucke V, Payrastre B, Bolino A.
Guerrero-Valero M, et al.
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2009469118. doi: 10.1073/pnas.2009469118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33653949
Free PMC article.
MTMR2 is a ubiquitously expressed catalytically active 3-phosphatase, which in vitro dephosphorylates the 3-phosphoinositides PtdIns3P and PtdIns(3,5)P(2), with a preference for PtdIns(3,5)P(2) A hallmark of CMT4B1 neuropathy are redundant loops of myelin in the nerve termed myel …
MTMR2 is a ubiquitously expressed catalytically active 3-phosphatase, which in vitro dephosphorylates the 3-phosphoinositides PtdIns3P and P …