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Year Number of Results
2010 2
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34 results

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Page 1
SELL and GUCY1A1 Gene Polymorphisms in Patients with Unstable Angina.
Malinowski D, Zawadzka M, Safranow K, Droździk M, Pawlik A. Malinowski D, et al. Biomedicines. 2022 Oct 6;10(10):2494. doi: 10.3390/biomedicines10102494. Biomedicines. 2022. PMID: 36289756 Free PMC article.
In SELL and GUCY1A1 genes, several polymorphisms have been detected, which may affect gene expression. ...Our results suggest that the SELL rs2205849 and rs2229569 and GUCY1A1 rs7692387 polymorphisms are not risk factors for unstable angina in the Polish population. …
In SELL and GUCY1A1 genes, several polymorphisms have been detected, which may affect gene expression. ...Our results suggest that th …
sGC Activity and Regulation of Blood Flow in a Zebrafish Model System.
Vishnolia KK, Rakovic A, Hoene C, Tarhbalouti K, Aherrahrou Z, Erdmann J. Vishnolia KK, et al. Front Physiol. 2021 Feb 25;12:633171. doi: 10.3389/fphys.2021.633171. eCollection 2021. Front Physiol. 2021. PMID: 33716783 Free PMC article.
This mutation resulted in a reduction of gucy1a1 expression in both heterozygote and homozygote zebrafish. Blood flow parameters (blood flow, arterial pulse, linear velocity, and vessel diameter) investigated in the gucy1a1 mutants showed a significant increase in b …
This mutation resulted in a reduction of gucy1a1 expression in both heterozygote and homozygote zebrafish. Blood flow parameters (blo …
Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion.
Meguro S, Johmura Y, Wang TW, Kawakami S, Tanimoto S, Omori S, Okamura YT, Hoshi S, Kayama E, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Kojima Y, Nakanishi M. Meguro S, et al. Nat Aging. 2024 Nov;4(11):1582-1597. doi: 10.1038/s43587-024-00704-1. Epub 2024 Sep 9. Nat Aging. 2024. PMID: 39251867 Free PMC article.
We identified high expression levels of SMOC2, GUCY1A1 (GUCY1A3), CXCL12, CRISPLD2, GAS1 and LUM as a signature of p16(h)-sn CAFs in humans and mice, which was associated with age and poor prognosis in patients with advanced and nonadvanced bladder cancer. ...
We identified high expression levels of SMOC2, GUCY1A1 (GUCY1A3), CXCL12, CRISPLD2, GAS1 and LUM as a signature of p16(h)-sn CAFs in …
Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma.
Liu H, Zhang Y, Zhang Q, Zhang T, Lu T. Liu H, et al. Front Biosci (Landmark Ed). 2023 Dec 1;28(12):328. doi: 10.31083/j.fbl2812328. Front Biosci (Landmark Ed). 2023. PMID: 38179743 Free article.
In addition, four potential immune-metabolic checkpoints (GUCY1A1, GUCY1B1, PDE1A and PDE5A) were identified, which could be used to improve the efficacy of immunotherapy in COAD....
In addition, four potential immune-metabolic checkpoints (GUCY1A1, GUCY1B1, PDE1A and PDE5A) were identified, which could be used to …
Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation.
Mauersberger C, Sager HB, Wobst J, Dang TA, Lambrecht L, Koplev S, Stroth M, Bettaga N, Schlossmann J, Wunder F, Friebe A, Björkegren JLM, Dietz L, Maas SL, van der Vorst EPC, Sandner P, Soehnlein O, Schunkert H, Kessler T. Mauersberger C, et al. Nat Cardiovasc Res. 2022 Dec;1(12):1174-1186. doi: 10.1038/s44161-022-00175-w. Epub 2022 Dec 12. Nat Cardiovasc Res. 2022. PMID: 37484062 Free PMC article.
Profiling of platelet-released cytokines indicated that reduced platelet angiopoietin-1 release by sGC-depleted platelets, which was validated in isolated human platelets from carriers of GUCY1A1 risk alleles, enhances leukocyte adhesion to ECs. I mp or ta ntly, p ha rm ac …
Profiling of platelet-released cytokines indicated that reduced platelet angiopoietin-1 release by sGC-depleted platelets, which was validat …
Network-Based and Machine-Learning Approaches Identify Diagnostic and Prognostic Models for EMT-Type Gastric Tumors.
Sadeghi M, Karimi MR, Karimi AH, Ghorbanpour Farshbaf N, Barzegar A, Schmitz U. Sadeghi M, et al. Genes (Basel). 2023 Mar 19;14(3):750. doi: 10.3390/genes14030750. Genes (Basel). 2023. PMID: 36981021 Free PMC article.
Using network analysis and linear discriminant analysis, we identified mRNA motifs and microRNA-based models with strong prognostic and diagnostic relevance: three models comprised of (i) the microRNAs miR-199a-5p and miR-141-3p, (ii) EVC/EVC2/GLI3, and (iii) PDE2A/GUCY1A1 …
Using network analysis and linear discriminant analysis, we identified mRNA motifs and microRNA-based models with strong prognostic and diag …
Integrated single-cell and bulk RNA sequencing identifies POSTN as a potential biomarker and therapeutic target for rheumatoid arthritis.
Li W, Li Z, Zou Z, Liu X, Li X. Li W, et al. Gene. 2024 Nov 30;928:148798. doi: 10.1016/j.gene.2024.148798. Epub 2024 Jul 25. Gene. 2024. PMID: 39067546
Subsequently, we intersected module genes with DEGs obtained from scRNA-seq and bulk RNA-seq and constructed a PPI network of hub genes (BGN, COL11A1, COL1A1, GUCY1A1, POSTN). In external validation cohorts, POSTN was highly expressed and demonstrated the highest diagnosti …
Subsequently, we intersected module genes with DEGs obtained from scRNA-seq and bulk RNA-seq and constructed a PPI network of hub genes (BGN …
Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes Affecting Risk of Hypertension.
Curtis D. Curtis D. Pulse (Basel). 2023 Nov 13;11(1):9-16. doi: 10.1159/000535157. eCollection 2023 Jan-Dec. Pulse (Basel). 2023. PMID: 38090255 Free PMC article.
Also exome-wide significant as risk genes for hypertension were GUCY1A1, ASXL1, and SMAD6, while GUCY1B1 had a nominal p value of <0.0001. GUCY1A1 and GUCY1B1 code for subunits of a soluble guanylate cyclase. ...
Also exome-wide significant as risk genes for hypertension were GUCY1A1, ASXL1, and SMAD6, while GUCY1B1 had a nominal p value of &lt …
Variability in aspirin efficacy: all in the genes?
Baigent C, Holmes MV. Baigent C, et al. Eur Heart J. 2019 Nov 1;40(41):3393-3396. doi: 10.1093/eurheartj/ehz456. Eur Heart J. 2019. PMID: 31280284 Free PMC article. No abstract available.
34 results