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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2002 1
2003 1
2004 2
2005 2
2006 1
2009 4
2010 3
2011 8
2012 10
2013 8
2014 10
2015 4
2016 18
2017 12
2018 11
2019 10
2020 13
2021 17
2022 9
2023 15
2024 3

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149 results

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Page 1
GUCY2C-targeted cancer immunotherapy: past, present and future.
Snook AE, Magee MS, Waldman SA. Snook AE, et al. Immunol Res. 2011 Dec;51(2-3):161-9. doi: 10.1007/s12026-011-8253-7. Immunol Res. 2011. PMID: 22038530 Free PMC article. Review.
GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C (Ad5-GUCY2C) as a candidate vaccine for colorectal cancer patients. ...
GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a reco …
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Mathur D, Root AR, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, Kearney JC, Lucas J, Guffroy M, Golas J, Rohde CM, Stevens C, Kamperschroer C, Kelleher K, Lawrence-Henderson RF, Upeslacis E, Yao J, Narula J, LaVallie ER, Fernandez DR, Buetow BS, Rosfjord E, Bloom L, King LE, Tchistiakova L, Nguyen A, Sapra P. Mathur D, et al. Clin Cancer Res. 2020 May 1;26(9):2188-2202. doi: 10.1158/1078-0432.CCR-19-3275. Epub 2020 Jan 29. Clin Cancer Res. 2020. PMID: 31996389
Here, we demonstrate potent, tumor-selective efficacy with PF-07062119, a T-cell engaging CD3 bispecific targeting tumors expressing Guanylyl Cyclase C (GUCY2C), which is expressed widely across colorectal cancer and other gastrointestinal malignancies. ...Toxicity and pha …
Here, we demonstrate potent, tumor-selective efficacy with PF-07062119, a T-cell engaging CD3 bispecific targeting tumors expressing Guanyly …
Intestinal neuropod cell GUCY2C regulates visceral pain.
Barton JR, Londregan AK, Alexander TD, Entezari AA, Bar-Ad S, Cheng L, Lepore AC, Snook AE, Covarrubias M, Waldman SA. Barton JR, et al. J Clin Invest. 2023 Feb 15;133(4):e165578. doi: 10.1172/JCI165578. J Clin Invest. 2023. PMID: 36548082 Free PMC article.
GUCY2Chi neuropod cells associated with cocultured dorsal root ganglia neurons and induced hyperexcitability, reducing the rheobase and increasing the resulting number of evoked action potentials. Conversely, the GUCY2C agonist linaclotide eliminated neuronal hyperexcitabi …
GUCY2Chi neuropod cells associated with cocultured dorsal root ganglia neurons and induced hyperexcitability, reducing the rheobase and incr …
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential.
Entezari AA, Snook AE, Waldman SA. Entezari AA, et al. Expert Opin Ther Targets. 2021 May;25(5):335-346. doi: 10.1080/14728222.2021.1937124. Epub 2021 Jun 15. Expert Opin Ther Targets. 2021. PMID: 34056991 Free PMC article. Review.
Furthermore, GUCY2C is a novel target for immunotherapy and a diagnostic marker for primary and metastatic diseases. EXPERT OPINION: There is an unmet need for prevention and therapy in GI cancers. In that context, GUCY2C is a promising target for prevention, althou …
Furthermore, GUCY2C is a novel target for immunotherapy and a diagnostic marker for primary and metastatic diseases. EXPERT OPINION: …
GUCY2C ligand replacement to prevent colorectal cancer.
Blomain ES, Pattison AM, Waldman SA. Blomain ES, et al. Cancer Biol Ther. 2016 Jul 2;17(7):713-8. doi: 10.1080/15384047.2016.1178429. Epub 2016 Apr 22. Cancer Biol Ther. 2016. PMID: 27104761 Free PMC article. Review.
CRC initiates and progresses over decades, canonically proceeding via a series of stepwise molecular events that turn a normal epithelium into a dysfunctional epithelium, then subsequently into an adenoma, and finally an invasive adenocarcinoma. An emerging paradigm suggests that …
CRC initiates and progresses over decades, canonically proceeding via a series of stepwise molecular events that turn a normal epithelium in …
Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3.
Rampuria P, Mosyak L, Root AR, Svenson K, Agostino MJ, LaVallie ER. Rampuria P, et al. Sci Rep. 2023 Aug 17;13(1):13408. doi: 10.1038/s41598-023-40467-0. Sci Rep. 2023. PMID: 37591971 Free PMC article.
The target epitope was localized to the N-terminal helix H2 of human GUCY2C, which enabled the determination of the crystal structure of the minimal GUCY2C epitope in complex with the anti-GUCY2C antibody domain. To understand if this minimal epitope covers t …
The target epitope was localized to the N-terminal helix H2 of human GUCY2C, which enabled the determination of the crystal structure …
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults.
Cheslow L, Byrne M, Kopenhaver JS, Iacovitti L, Smeyne RJ, Snook AE, Waldman SA. Cheslow L, et al. Res Sq [Preprint]. 2023 Oct 13:rs.3.rs-3416338. doi: 10.21203/rs.3.rs-3416338/v1. Res Sq. 2023. PMID: 37886524 Free PMC article. Updated. Preprint.
GUCY2C is overexpressed in the SNpc in PD patients and in mice treated with MPTP, possibly reflecting a protective response to oxidative stress. ...These observations reveal a previously unexpected role for the GUCY2C-cGMP signaling axis in controlling mitochondrial …
GUCY2C is overexpressed in the SNpc in PD patients and in mice treated with MPTP, possibly reflecting a protective response to oxidat …
GUCY2C molecular staging personalizes colorectal cancer patient management.
Gong JP, Schulz S, Hyslop T, Waldman SA. Gong JP, et al. Biomark Med. 2012 Jun;6(3):339-48. doi: 10.2217/bmm.12.24. Biomark Med. 2012. PMID: 22731908 Free PMC article. Review.
This review describes the evolution of the tumor suppressor GUCY2C as a prognostic and predictive molecular biomarker that quantifies occult tumor burden in regional lymph nodes for staging patients with colorectal cancer....
This review describes the evolution of the tumor suppressor GUCY2C as a prognostic and predictive molecular biomarker that quantifies …
GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. Li P, et al. Cancer Res. 2017 Sep 15;77(18):5095-5106. doi: 10.1158/0008-5472.CAN-17-0859. Cancer Res. 2017. PMID: 28916678 Free PMC article.
Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS. Eliminating GUCY2C signaling exacerbated RIGS, amplifying radiation-induced mortality, weight loss, mucosal bleeding, debilitation, and intestinal dysfunction. Durable exp …
Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS. Eliminating GUCY2C signaling ex …
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.
Magee MS, Kraft CL, Abraham TS, Baybutt TR, Marszalowicz GP, Li P, Waldman SA, Snook AE. Magee MS, et al. Oncoimmunology. 2016 Sep 2;5(10):e1227897. doi: 10.1080/2162402X.2016.1227897. eCollection 2016. Oncoimmunology. 2016. PMID: 27853651 Free PMC article.
T cells expressing CARs directed by a GUCY2C-specific antibody fragment recognized GUCY2C, quantified by expression of activation markers and cytokines. Further, GUCY2C CAR-T cells lysed GUCY2C-expressing, but not GUCY2C-deficient, mouse colorec …
T cells expressing CARs directed by a GUCY2C-specific antibody fragment recognized GUCY2C, quantified by expression of activat …
149 results