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Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis.
Stiebel-Kalish H, Reich E, Rainy N, Vatine G, Nisgav Y, Tovar A, Gothilf Y, Bach M. Stiebel-Kalish H, et al. Eur J Hum Genet. 2012 Aug;20(8):884-9. doi: 10.1038/ejhg.2012.10. Epub 2012 Feb 29. Eur J Hum Genet. 2012. PMID: 22378290 Free PMC article.
Histological changes in the Gucy2f-knockdown larvae included loss and shortening of cone and rod outer segments. A zebrafish model of Gucy2f-related LCA1 displays early visual dysfunction and photoreceptor layer dystrophy. ...
Histological changes in the Gucy2f-knockdown larvae included loss and shortening of cone and rod outer segments. A zebrafish model of …
Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion.
Karan S, Frederick JM, Baehr W. Karan S, et al. Mol Cell Biochem. 2010 Jan;334(1-2):141-55. doi: 10.1007/s11010-009-0322-z. Epub 2009 Dec 9. Mol Cell Biochem. 2010. PMID: 20012162 Free PMC article. Review.
In mouse, a GC-E null genotype produces a recessive cone dystrophy, while rods remain functional. Rod function is supported by the presence of GC-F (Gucy2f), a close relative of GC-E. Deletion of Gucy2f has very little effect on rod and cone physiology and survival. …
In mouse, a GC-E null genotype produces a recessive cone dystrophy, while rods remain functional. Rod function is supported by the presence …
Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6.
Mellen RW, Calabro KR, McCullough KT, Crosson SM, Cova A, Fajardo D, Xu E, Boye SL, Boye SE. Mellen RW, et al. Mol Ther Methods Clin Dev. 2023 Jun 1;30:48-64. doi: 10.1016/j.omtm.2023.05.020. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37361352 Free PMC article.
Next, we established a proof of concept for "ablate and replace" and optimized vector doses in Gucy2e(+/-):Gucy2f(-/-) and Gucy2f(-/-) mice, respectively. Finally, we confirmed that the "ablate and replace" approach stably preserved retinal structure and function in …
Next, we established a proof of concept for "ablate and replace" and optimized vector doses in Gucy2e(+/-):Gucy2f(-/-) and Gucy2f …
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Wood LD, Calhoun ES, Silliman N, Ptak J, Szabo S, Powell SM, Riggins GJ, Wang TL, Yan H, Gazdar A, Kern SE, Pennacchio L, Kinzler KW, Vogelstein B, Velculescu VE. Wood LD, et al. Hum Mutat. 2006 Oct;27(10):1060-1. doi: 10.1002/humu.9452. Hum Mutat. 2006. PMID: 16941478
In this study we have used high-throughput sequencing approaches to further evaluate this subset of genes for genetic alterations in other human tumors. We identified somatic mutations in GUCY2F, EPHA3, and NTRK3 in breast, lung, and pancreatic cancers. ...
In this study we have used high-throughput sequencing approaches to further evaluate this subset of genes for genetic alterations in other h …
Pulmonary Hypertension Associated Genetic Variants in Sarcoidosis Associated Pulmonary Hypertension.
Groen K, Huitema MP, van der Vis JJ, Post MC, Grutters JC, Baughman RP, van Moorsel CHM. Groen K, et al. Diagnostics (Basel). 2022 Oct 21;12(10):2564. doi: 10.3390/diagnostics12102564. Diagnostics (Basel). 2022. PMID: 36292254 Free PMC article.
First, the NOTCH3 gene that was previously linked to PH, and furthermore PDE6B, GUCY2F, COL5A1, and MMP21. CONCLUSIONS: The increased frequency of variants in PH genes in SAPH suggests a mechanism whereby the presence of such a genetic variant in a patient may increase ris …
First, the NOTCH3 gene that was previously linked to PH, and furthermore PDE6B, GUCY2F, COL5A1, and MMP21. CONCLUSIONS: The increased …
Guanylate cyclases and associated activator proteins in retinal disease.
Hunt DM, Buch P, Michaelides M. Hunt DM, et al. Mol Cell Biochem. 2010 Jan;334(1-2):157-68. doi: 10.1007/s11010-009-0331-y. Epub 2009 Nov 26. Mol Cell Biochem. 2010. PMID: 19941038 Review.
Two isoforms of guanylate cyclase, GC1 and GC2 encoded by GUCY2D and GUCY2F, are responsible for the replenishment of cGMP in photoreceptors after exposure to light. ...
Two isoforms of guanylate cyclase, GC1 and GC2 encoded by GUCY2D and GUCY2F, are responsible for the replenishment of cGMP in photore …
Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved.
Gao D, Wang C, Xi Z, Zhou Y, Wang Y, Zuo Z. Gao D, et al. Toxicol Sci. 2017 May 1;157(1):74-84. doi: 10.1093/toxsci/kfx028. Toxicol Sci. 2017. PMID: 28329817
MeDIP-sequencing data of the 96 hpf larvae identified 235 differentially methylated genes in promoter, with the fold change > 1.5. Guanylate cyclase 2F (gucy2f) and dopamine receptor D4 related sequence (drd4-rs) were hypermethylation promoters, whereas zinc finger C4H2 …
MeDIP-sequencing data of the 96 hpf larvae identified 235 differentially methylated genes in promoter, with the fold change > 1.5. Guanyl …
A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration.
Maddison LA, Lu J, Victoroff T, Scott E, Baier H, Chen W. Maddison LA, et al. Mol Genet Genomics. 2009 May;281(5):551-63. doi: 10.1007/s00438-009-0428-8. Epub 2009 Feb 17. Mol Genet Genomics. 2009. PMID: 19221799 Free PMC article.
We further demonstrate that misexpression of one such downstream gene gucy2F, a membrane-bound guanylate cyclase, throughout the nervous system results in multiple defects including a loss of forebrain neurons. ...
We further demonstrate that misexpression of one such downstream gene gucy2F, a membrane-bound guanylate cyclase, throughout the nerv …
Detection of Selection Signatures on the X Chromosome in Three Sheep Breeds.
Zhu C, Fan H, Yuan Z, Hu S, Zhang L, Wei C, Zhang Q, Zhao F, Du L. Zhu C, et al. Int J Mol Sci. 2015 Aug 28;16(9):20360-74. doi: 10.3390/ijms160920360. Int J Mol Sci. 2015. PMID: 26343642 Free PMC article.
We also identified some selection regions harboring genes that had human orthologs, including BKT, CENPI, GUCY2F, MSN, PCDH11X, PLP1, VSIG4, PAK3, WAS, PCDH19, PDHA1, and SRPX2. ...
We also identified some selection regions harboring genes that had human orthologs, including BKT, CENPI, GUCY2F, MSN, PCDH11X, PLP1, …
A model for transport of membrane-associated phototransduction polypeptides in rod and cone photoreceptor inner segments.
Karan S, Zhang H, Li S, Frederick JM, Baehr W. Karan S, et al. Vision Res. 2008 Feb;48(3):442-52. doi: 10.1016/j.visres.2007.08.020. Epub 2007 Oct 18. Vision Res. 2008. PMID: 17949773 Free PMC article. Review.
We discuss putative mechanisms of membrane protein transport in photoreceptors based on Pde6d and Gucy2e/Gucy2f knockout mice. Knockout of the Pde6d gene encoding PrBP/delta, a prenyl binding protein present in the retina at relatively high levels, was shown to impair tran …
We discuss putative mechanisms of membrane protein transport in photoreceptors based on Pde6d and Gucy2e/Gucy2f knockout mice. Knocko …
25 results