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Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes.
Diabetes Ther. 2024 May;15(5):1069-1084. doi: 10.1007/s13300-024-01566-x. Epub 2024 Apr 4.
Diabetes Ther. 2024.
PMID: 38573467
Free PMC article.
Review.
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker DJ, Finan B, Grandl G, Gutgesell R, Hofmann SM, Khalil A, Liu X, Cota P, Bakhti M, Czarnecki O, Bastidas-Ponce A, Lickert H, Kang L, Maity G, Novikoff A, Parlee S, Pathak E, Schriever SC, Sterr M, Ussar S, Zhang Q, DiMarchi R, Tschöp MH, Pfluger PT, Douros JD, Müller TD.
Akindehin S, et al. Among authors: gutgesell r.
Mol Metab. 2024 May;83:101915. doi: 10.1016/j.molmet.2024.101915. Epub 2024 Mar 14.
Mol Metab. 2024.
PMID: 38492844
Free PMC article.
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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.
Liskiewicz A, Khalil A, Liskiewicz D, Novikoff A, Grandl G, Maity-Kumar G, Gutgesell RM, Bakhti M, Bastidas-Ponce A, Czarnecki O, Makris K, Lickert H, Feuchtinger A, Tost M, Coupland C, Ständer L, Akindehin S, Prakash S, Abrar F, Castelino RL, He Y, Knerr PJ, Yang B, Hogendorf WFJ, Zhang S, Hofmann SM, Finan B, DiMarchi RD, Tschöp MH, Douros JD, Müller TD.
Liskiewicz A, et al. Among authors: gutgesell rm.
Nat Metab. 2023 Dec;5(12):2075-2085. doi: 10.1038/s42255-023-00931-7. Epub 2023 Nov 9.
Nat Metab. 2023.
PMID: 37946085
Free PMC article.
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The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.
Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR.
Desjardins EM, et al. Among authors: gutgesell rm.
Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2119824119. doi: 10.1073/pnas.2119824119. Epub 2022 Nov 21.
Proc Natl Acad Sci U S A. 2022.
PMID: 36409897
Free PMC article.
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Naphthenic acid fraction components from oil sands process-affected water from the Athabasca Oil Sands Region impair murine osteoblast differentiation and function.
Gutgesell RM, Jamshed L, Frank RA, Hewitt LM, Thomas PJ, Holloway AC.
Gutgesell RM, et al.
J Appl Toxicol. 2022 Dec;42(12):2005-2015. doi: 10.1002/jat.4370. Epub 2022 Aug 16.
J Appl Toxicol. 2022.
PMID: 35894097
Free PMC article.
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The effects of oil sands process-affected water naphthenic acid fraction components on GDF15 secretion in extravillous trophoblast cells.
Jamshed L, Perono GA, Yacoub LR, Gutgesell RM, Frank RA, Hewitt LM, Thomas PJ, Holloway AC.
Jamshed L, et al. Among authors: gutgesell rm.
Toxicol Appl Pharmacol. 2022 Apr 15;441:115970. doi: 10.1016/j.taap.2022.115970. Epub 2022 Mar 5.
Toxicol Appl Pharmacol. 2022.
PMID: 35259347
Free article.
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Impact of pesticide exposure on adipose tissue development and function.
Gutgesell RM, Tsakiridis EE, Jamshed S, Steinberg GR, Holloway AC.
Gutgesell RM, et al.
Biochem J. 2020 Jul 31;477(14):2639-2653. doi: 10.1042/BCJ20200324.
Biochem J. 2020.
PMID: 32726435
Review.
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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.
Day EA, Ford RJ, Smith BK, Mohammadi-Shemirani P, Morrow MR, Gutgesell RM, Lu R, Raphenya AR, Kabiri M, McArthur AG, McInnes N, Hess S, Paré G, Gerstein HC, Steinberg GR.
Day EA, et al. Among authors: gutgesell rm.
Nat Metab. 2019 Dec;1(12):1202-1208. doi: 10.1038/s42255-019-0146-4. Epub 2019 Dec 9.
Nat Metab. 2019.
PMID: 32694673
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