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Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.
Höfling C, Kulesskaya N, Jaako K, Peltonen I, Männistö PT, Nurmi A, Vartiainen N, Morawski M, Zharkovsky A, Võikar V, Roßner S, García-Horsman JA. Höfling C, et al. Eur Neuropsychopharmacol. 2016 Jun;26(6):1048-61. doi: 10.1016/j.euroneuro.2016.02.015. Epub 2016 Feb 27. Eur Neuropsychopharmacol. 2016. PMID: 26996375
Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition.
Shah D, Praet J, Latif Hernandez A, Höfling C, Anckaerts C, Bard F, Morawski M, Detrez JR, Prinsen E, Villa A, De Vos WH, Maggi A, D'Hooge R, Balschun D, Rossner S, Verhoye M, Van der Linden A. Shah D, et al. Among authors: hofling c. Alzheimers Dement. 2016 Sep;12(9):964-976. doi: 10.1016/j.jalz.2016.03.010. Epub 2016 Apr 21. Alzheimers Dement. 2016. PMID: 27107518
Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.
Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH. Höfling C, et al. Aging Cell. 2016 Oct;15(5):953-63. doi: 10.1111/acel.12508. Epub 2016 Jul 29. Aging Cell. 2016. PMID: 27470171 Free PMC article.
76 results