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Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, Kelleher NL, Staudt LM, Skoultchi AI, Keogh MC, Apostolou E, Mason CE, Imielinski M, Schlick T, David Y, Tsirigos A, Allis CD, Soshnev AA, Cesarman E, Melnick AM. Yusufova N, et al. Nature. 2021 Jan;589(7841):299-305. doi: 10.1038/s41586-020-3017-y. Epub 2020 Dec 9. Nature. 2021. PMID: 33299181 Free PMC article.
Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-3 and H1-4, respectively) are highly recurrent in B cell lymphomas, but the pathogenic relevance of these mutations to cancer and the mechanisms that are i …
Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-3 and H1-4, respective …
HIST1H1E Syndrome.
Burkardt D, Tatton-Brown K. Burkardt D, et al. 2020 Dec 3 [updated 2022 Dec 15]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2020 Dec 3 [updated 2022 Dec 15]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 33270410 Free Books & Documents. Review.
To date, all probands reported with HIST1H1E syndrome whose parents have undergone molecular genetic testing have the disorder as a result of a de novo H1-4 pathogenic variant. If the H1-4 pathogenic variant found in the proband cannot be detected in t …
To date, all probands reported with HIST1H1E syndrome whose parents have undergone molecular genetic testing have the disorder as a result o …
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H. Chang S, et al. Exp Mol Med. 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. Exp Mol Med. 2019. PMID: 31221981 Free PMC article. Review.
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts of cancer development. The cancer genome atlas (TCGA) project identified 299 genes and 24 pathways/biological processes that …
Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts …
Linker Histone H1.4 Inhibits the Growth, Migration and EMT Process of Non-Small Cell Lung Cancer by Regulating ERK1/2 Expression.
Chen Q, Yang M, Duan X, Zhang J, Shi F, Chen R, Li Y. Chen Q, et al. Biochem Genet. 2024 Mar 12. doi: 10.1007/s10528-024-10760-2. Online ahead of print. Biochem Genet. 2024. PMID: 38472566
H1.4 is one of the 11 variants of linker histone H1, and is associated with tumorigenesis and development of various cancers. However, it is unclear for the role of histone H1.4 in non-small cell lung cancer (NSCLC). In this study, we fou …
H1.4 is one of the 11 variants of linker histone H1, and is associated with tumorigenesis and development of various cancer …
K-Ras(G12V/Y40C)-PI3K/AKT pathway regulates H1.4(S35ph) through PKA to promote the occurrence and development of osteosarcoma cancer.
Zhang J, Liu W, Dong H, Wang W. Zhang J, et al. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2048-2057. doi: 10.1080/21691401.2019.1617726. Artif Cells Nanomed Biotechnol. 2019. PMID: 31126199 Retracted.
Background: Osteosarcoma is prevalent in children and adolescents. H1.4 modification is involved in various types of cancers. Ras pathway is often activated in human cancers. ...Highlights H1.4(S35ph) is regulated by K-Ras(G12V/Y40)-PI3K/ …
Background: Osteosarcoma is prevalent in children and adolescents. H1.4 modification is involved in various types of cancer …
Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability.
Tatton-Brown K, Loveday C, Yost S, Clarke M, Ramsay E, Zachariou A, Elliott A, Wylie H, Ardissone A, Rittinger O, Stewart F, Temple IK, Cole T; Childhood Overgrowth Collaboration; Mahamdallie S, Seal S, Ruark E, Rahman N. Tatton-Brown K, et al. Am J Hum Genet. 2017 May 4;100(5):725-736. doi: 10.1016/j.ajhg.2017.03.010. Am J Hum Genet. 2017. PMID: 28475857 Free PMC article.
We identified a causal mutation in 1 of 14 genes in 50% (353/710). This includes HIST1H1E, encoding histone H1.4, which has not been associated with a developmental disorder previously. ...However, the mutation spectra of genes involved in OGID and cancer dif …
We identified a causal mutation in 1 of 14 genes in 50% (353/710). This includes HIST1H1E, encoding histone H1.4, which has no …
Histone H1 phosphorylation in breast cancer.
Harshman SW, Hoover ME, Huang C, Branson OE, Chaney SB, Cheney CM, Rosol TJ, Shapiro CL, Wysocki VH, Huebner K, Freitas MA. Harshman SW, et al. J Proteome Res. 2014 May 2;13(5):2453-67. doi: 10.1021/pr401248f. Epub 2014 Apr 7. J Proteome Res. 2014. PMID: 24601643 Free PMC article.
Breast cancer is the second leading cause of cancer-related deaths in women. ...The results suggest that the phosphorylation at threonine 146 is found on both histone H1.2 and histone H1.4. Cell lines were then treated with an extracellular stimulus, e …
Breast cancer is the second leading cause of cancer-related deaths in women. ...The results suggest that the phosphorylation a …
Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats.
Izquierdo-Bouldstridge A, Bustillos A, Bonet-Costa C, Aribau-Miralbés P, García-Gomis D, Dabad M, Esteve-Codina A, Pascual-Reguant L, Peiró S, Esteller M, Murtha M, Millán-Ariño L, Jordan A. Izquierdo-Bouldstridge A, et al. Nucleic Acids Res. 2017 Nov 16;45(20):11622-11642. doi: 10.1093/nar/gkx746. Nucleic Acids Res. 2017. PMID: 28977426 Free PMC article.
Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) of each H1 variant in breast cancer cells results in altered gene expression and proliferation differently in a variant specific man …
Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) …
Ubiquitin-conjugating enzyme E2C: a potential cancer biomarker.
Xie C, Powell C, Yao M, Wu J, Dong Q. Xie C, et al. Int J Biochem Cell Biol. 2014 Feb;47:113-7. doi: 10.1016/j.biocel.2013.11.023. Epub 2013 Dec 17. Int J Biochem Cell Biol. 2014. PMID: 24361302 Review.
The UBE2C mRNA and/or protein levels are aberrantly increased in many cancer types with poor clinical outcomes. Accumulation of UBE2C stimulates cell proliferation and anchorage-independent growth. ...
The UBE2C mRNA and/or protein levels are aberrantly increased in many cancer types with poor clinical outcomes. Accumulation of UBE2C …
Molecular Mechanism of the Pin1-Histone H1 Interaction.
Jinasena D, Simmons R, Gyamfi H, Fitzkee NC. Jinasena D, et al. Biochemistry. 2019 Feb 12;58(6):788-798. doi: 10.1021/acs.biochem.8b01036. Epub 2018 Dec 18. Biochemistry. 2019. PMID: 30507159 Free PMC article.
This Pin1-histone H1 interaction plays a key role in pathogen response, in infection, and in cell cycle control; therefore, anti-Pin1 therapeutics are an important focus for treating infections as well as cancer. Each of the H1 histones (H1.0-H1.5) contains several potenti …
This Pin1-histone H1 interaction plays a key role in pathogen response, in infection, and in cell cycle control; therefore, anti-Pin1 therap …
58 results