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Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.
Lubin E, Bryant L, Aicher J, Li D, Bhoj E. Lubin E, et al. Hum Genet. 2022 Aug;141(8):1409-1421. doi: 10.1007/s00439-022-02432-1. Epub 2022 Jan 24. Hum Genet. 2022. PMID: 35072799
Five of the six genes predicted to be disease-causing with an underlying germline loss-of-function variant are novel disease-candidate genes (H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0). These findings may serve as a focused reference for future sequencing of patients with the cons …
Five of the six genes predicted to be disease-causing with an underlying germline loss-of-function variant are novel disease-candidate genes …
Cloning of cDNAs for H1F0, TOP1, CLTA and CDK1 and the effects of cryopreservation on the expression of their mRNA transcripts in yak (Bos grunniens) oocytes.
Niu HR, Zi XD, Xiao X, Xiong XR, Zhong JC, Li J, Wang L, Wang Y. Niu HR, et al. Cryobiology. 2014 Aug;69(1):55-60. doi: 10.1016/j.cryobiol.2014.05.002. Epub 2014 May 20. Cryobiology. 2014. PMID: 24854867
INTRODUCTION: We cloned and sequenced four pivotal cDNAs involved in DNA structural maintenance (H1F0 and TOP1) and the cell cycle (CLTA and CDK1) from yak oocytes. ...The overall mRNA expression levels of these four transcripts were reduced by F/T process, albeit at diffe …
INTRODUCTION: We cloned and sequenced four pivotal cDNAs involved in DNA structural maintenance (H1F0 and TOP1) and the cell cycle (C …
Identification and Characterization of mRNA Biomarkers for Sodium Cyanide Exposure.
Kim M, Jee SC, Kim S, Hwang KH, Sung JS. Kim M, et al. Toxics. 2021 Nov 2;9(11):288. doi: 10.3390/toxics9110288. Toxics. 2021. PMID: 34822678 Free PMC article.
We identified the following mRNA biomarker candidates: ADCY5, ANGPTL4, CCNG2, CD9, COL1A2, DACT3, GGCX, GRB14, H1F0, HSPA1A, MAF, MAT2A, PPP1R10, and PPP4C. The expression levels of these candidates were commonly downregulated by sodium cyanide exposure both in vitro and i …
We identified the following mRNA biomarker candidates: ADCY5, ANGPTL4, CCNG2, CD9, COL1A2, DACT3, GGCX, GRB14, H1F0, HSPA1A, MAF, MAT …
DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome.
Bradic M, Taleb S, Thomas B, Chidiac O, Robay A, Hassan N, Malek J, Ait Hssain A, Abi Khalil C. Bradic M, et al. J Transl Med. 2022 Nov 12;20(1):526. doi: 10.1186/s12967-022-03737-5. J Transl Med. 2022. PMID: 36371196 Free PMC article. Clinical Trial.
The multivariate Cox proportional risk regression analysis showed that higher methylation of the "Apoptotic execution Pathway" genes (ROC1, ZNF789, and H1F0) at inclusion increases mortality risk by over twofold. CONCLUSION: We observed an epigenetic signature of immune-re …
The multivariate Cox proportional risk regression analysis showed that higher methylation of the "Apoptotic execution Pathway" genes (ROC1, …
Downregulation of HINFP induces senescence-associated secretory phenotype to promote metastasis in a non-cell-autonomous manner in bladder cancer.
Zheng X, Liu Z, Zhong J, Zhou L, Chen J, Zheng L, Li Z, Zhang R, Pan J, Wu Y, Liu Z, Kang T. Zheng X, et al. Oncogene. 2022 Jul;41(28):3587-3598. doi: 10.1038/s41388-022-02371-1. Epub 2022 Jun 6. Oncogene. 2022. PMID: 35668172
Here, we found that heterogeneous downregulation of histone H4 transcription factor (HINFP) was associated with senescence in BC tissues and that lower HINFP expression could predict an unfavorable outcome in BC patients. Knockout of HINFP transcriptionally inhibited H1F0 …
Here, we found that heterogeneous downregulation of histone H4 transcription factor (HINFP) was associated with senescence in BC tissues and …
The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection.
Lau CI, Rowell J, Yanez DC, Solanki A, Ross S, Ono M, Crompton T. Lau CI, et al. Development. 2021 Aug 1;148(15):dev199754. doi: 10.1242/dev.199754. Epub 2021 Jul 29. Development. 2021. PMID: 34323272 Free PMC article.
Foxa1 and Foxa2 regulated the expression of many genes encoding splicing factors and regulators, including Mbnl1, H1f0, Sf3b1, Hnrnpa1, Rnpc3, Prpf4b, Prpf40b and Snrpd3. Within the positively selecting CD69+DP cells, alternative RNA splicing was dysregulated in the double …
Foxa1 and Foxa2 regulated the expression of many genes encoding splicing factors and regulators, including Mbnl1, H1f0, Sf3b1, Hnrnpa …
Temporally and Spatially Regulated Expression of the Linker Histone H1fx During Mouse Development.
Ichihara-Tanaka K, Kadomatsu K, Kishida S. Ichihara-Tanaka K, et al. J Histochem Cytochem. 2017 Sep;65(9):513-530. doi: 10.1369/0022155417723914. Epub 2017 Aug 2. J Histochem Cytochem. 2017. PMID: 28766996 Free PMC article.
Western blot analysis of brain tissues demonstrated that the total expression level of H1fx gradually decreased with time from E12.5 to adulthood, whereas H1f0 was increased over this period. In adult mice, H1fx was restrictively expressed at the hypothalamus, subventricul …
Western blot analysis of brain tissues demonstrated that the total expression level of H1fx gradually decreased with time from E12.5 to adul …
Two predicted models based on ceRNAs and immune cells in lung adenocarcinoma.
Zhang M, Zheng P, Wang Y, Sun B. Zhang M, et al. PeerJ. 2021 Mar 23;9:e11029. doi: 10.7717/peerj.11029. eCollection 2021. PeerJ. 2021. PMID: 33828913 Free PMC article.
We further investigated the relationships between seven genes and immune/stromal scores via the ESTIMATE algorithm. The results indicated that CDC14A and H1F0 expression were significantly related to stromal scores/immune scores in LUAD. ...
We further investigated the relationships between seven genes and immune/stromal scores via the ESTIMATE algorithm. The results indicated th …
Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.
Greliche N, Zeller T, Wild PS, Rotival M, Schillert A, Ziegler A; Cardiogenics Consortium; Deloukas P, Erdmann J, Hengstenberg C, Ouwehand WH, Samani NJ, Schunkert H, Munzel T, Lackner KJ, Cambien F, Goodall AH, Tiret L, Blankenberg S, Trégouët DA. Greliche N, et al. PLoS One. 2012;7(9):e45863. doi: 10.1371/journal.pone.0045863. Epub 2012 Sep 21. PLoS One. 2012. PMID: 23029284 Free PMC article.
In addition, we identified two robust miSNPs 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes.As some of the aforementioned genes h …
In addition, we identified two robust miSNPs 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second …
19 results