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1986 1
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2008 2
2009 1
2014 2
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2019 1
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2023 4
2024 0

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Page 1
Deciphering the immunopeptidome in vivo reveals new tumour antigens.
Jaeger AM, Stopfer LE, Ahn R, Sanders EA, Sandel DA, Freed-Pastor WA, Rideout WM 3rd, Naranjo S, Fessenden T, Nguyen KB, Winter PS, Kohn RE, Westcott PMK, Schenkel JM, Shanahan SL, Shalek AK, Spranger S, White FM, Jacks T. Jaeger AM, et al. Nature. 2022 Jul;607(7917):149-155. doi: 10.1038/s41586-022-04839-2. Epub 2022 Jun 15. Nature. 2022. PMID: 35705813 Free PMC article.
To overcome these limitations, we engineered an inducible affinity tag into the mouse MHC-I gene (H2-K1) and targeted this allele to the Kras(LSL-G12D/+)Trp53(fl/fl) mouse model (KP/K(b)Strep)(7). ...
To overcome these limitations, we engineered an inducible affinity tag into the mouse MHC-I gene (H2-K1) and targeted this all …
Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration.
Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA. Kathiriya JJ, et al. Cell Stem Cell. 2020 Mar 5;26(3):346-358.e4. doi: 10.1016/j.stem.2019.12.014. Epub 2020 Jan 23. Cell Stem Cell. 2020. PMID: 31978363 Free PMC article.
After bleomycin injury, H2-K1 cells expand and differentiate in vivo to alveolar lineages. ...Normal H2-K1(high) cells transplanted into injured lungs differentiate into alveolar cells and rescue lung function. ...
After bleomycin injury, H2-K1 cells expand and differentiate in vivo to alveolar lineages. ...Normal H2-K1(high) …
Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration.
Xiong W, Chen Y, Zhang C, Li J, Huang H, Zhu Y, Deng G, Cheng J, Lin Y, Shi Z, Mou T. Xiong W, et al. J Transl Med. 2023 Jun 26;21(1):416. doi: 10.1186/s12967-023-04079-6. J Transl Med. 2023. PMID: 37365574 Free PMC article.
METHODS: AOM/DSS model in Il11(-/-) and Apc(min/+)/Il11(-/-) mice were used to detect tumor growth and CD8(+) T infiltration. STAT1/3 phosphorylation and MHC-I, CXCL9, H2-K1 and H2-D1 expression were detected in MC38 cells and intestine organoids treated with/withou …
METHODS: AOM/DSS model in Il11(-/-) and Apc(min/+)/Il11(-/-) mice were used to detect tumor growth and CD8(+) T infiltration. STAT1/3 phosph …
Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans.
Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Tooley KB, Stout MB, Rice HC, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Ocañas SR, Freeman WM. Kellogg CM, et al. Geroscience. 2023 Oct;45(5):3019-3043. doi: 10.1007/s11357-023-00859-6. Epub 2023 Jul 1. Geroscience. 2023. PMID: 37393197 Free PMC article.
Translating ribosome affinity purification-qPCR analysis of 3-6- and 18-22-month-old (m.o.) mice revealed significant age-related microglial induction of MHC-I pathway genes B2m, H2-D1, H2-K1, H2-M3, H2-Q6, and Tap1 but not in astrocytes and neurons. ...
Translating ribosome affinity purification-qPCR analysis of 3-6- and 18-22-month-old (m.o.) mice revealed significant age-related microglial …
Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans.
Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Tooley K, Stout MB, Rice HC, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Ocañas SR, Freeman WM. Kellogg CM, et al. bioRxiv [Preprint]. 2023 Jun 2:2023.03.07.531435. doi: 10.1101/2023.03.07.531435. bioRxiv. 2023. PMID: 36945372 Free PMC article. Updated. Preprint.
Translating Ribosome Affinity Purification-qPCR analysis of 3-6 and 18-22 month old (m.o.) mice revealed significant age-related microglial induction of MHC-I pathway genes B2m , H2-D1 , H2-K1 , H2-M3 , H2-Q6 , and Tap1 but not in astrocytes and neurons. ...
Translating Ribosome Affinity Purification-qPCR analysis of 3-6 and 18-22 month old (m.o.) mice revealed significant age-related microglial …
IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii.
Suzuki Y, Lutshumba J, Chen KC, Abdelaziz MH, Sa Q, Ochiai E. Suzuki Y, et al. Front Cell Infect Microbiol. 2023 Feb 15;13:1110508. doi: 10.3389/fcimb.2023.1110508. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 36875520 Free PMC article.
Importantly, IFN-gamma produced by brain-resident cells also upregulated cerebral expression of molecules for facilitating the protective T cell immunity, which include the molecules for 1) recruiting effector T cells (CXCL9, CXCL10, and CXCL11), 2) antigen processing (PA28alphab …
Importantly, IFN-gamma produced by brain-resident cells also upregulated cerebral expression of molecules for facilitating the protective T …
Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes.
Li H, Ngan HL, Liu Y, Chan HHY, Poon PHY, Yeung CK, Peng Y, Lam WY, Li BX, He Y, Lui VWY. Li H, et al. Cancers (Basel). 2020 Oct 12;12(10):2935. doi: 10.3390/cancers12102935. Cancers (Basel). 2020. PMID: 33053752 Free PMC article.
Collectively, the five models harbor genetic aberrations across 10 cancer hallmarks and 14 signaling pathways and machineries (metabolic, epigenetic, immune evasion), to extents similar in patients. Immune defects in HLA-A (H2-Q10, H2-Q4, H2-Q7, and H2-K1), Pdcd1, T …
Collectively, the five models harbor genetic aberrations across 10 cancer hallmarks and 14 signaling pathways and machineries (metabolic, ep …
Kinetics and product branching ratios of the reaction of (1)CH2 with H2 and D2.
Gannon KL, Blitz MA, Pilling MJ, Seakins PW, Klippenstein SJ, Harding LB. Gannon KL, et al. J Phys Chem A. 2008 Oct 2;112(39):9575-83. doi: 10.1021/jp803038s. Epub 2008 Aug 20. J Phys Chem A. 2008. PMID: 18714945
The rate coefficients for the removal of singlet methylene with H2 (k1) and D2 (k2) have been measured from 195 to 798 K and are essentially temperature-independent with values of k1 = (10.48 +/- 0.32) x 10(-11) cm(3) molecule(-1) s(-1) and k2 = (5.98 +/- 0.34) x 10 …
The rate coefficients for the removal of singlet methylene with H2 (k1) and D2 (k2) have been measured from 195 to 798 K and a …
DNMT1 regulates expression of MHC class I in post-mitotic neurons.
Gustafsson JR, Katsioudi G, Degn M, Ejlerskov P, Issazadeh-Navikas S, Kornum BR. Gustafsson JR, et al. Mol Brain. 2018 Jul 3;11(1):36. doi: 10.1186/s13041-018-0380-9. Mol Brain. 2018. PMID: 29970123 Free PMC article.
In conclusion, we show that while the mouse H2-D1/L alleles are suppressed in neurons by DNMT1 activity under normal circumstances, the H2-K1 allele is not. This finding is particularly important in two instances. ...
In conclusion, we show that while the mouse H2-D1/L alleles are suppressed in neurons by DNMT1 activity under normal circumstances, the H …
Lactiplantibacillus plantarum LOC1 Isolated from Fresh Tea Leaves Modulates Macrophage Response to TLR4 Activation.
Suzuki M, Albarracin L, Tsujikawa Y, Fukuyama K, Sakane I, Villena J, Kitazawa H. Suzuki M, et al. Foods. 2022 Oct 18;11(20):3257. doi: 10.3390/foods11203257. Foods. 2022. PMID: 37431006 Free PMC article.
The LOC1 strain markedly reduced the LPS-induced expression of some inflammatory cytokines (IL-1beta, IL-12, and CSF2) and chemokines (CCL17, CCL28, CXCL3, CXCL13, CXCL1, and CX3CL1), while it significantly increased the expression of other cytokines (TNF-alpha, IL-6, IL-18, IFN- …
The LOC1 strain markedly reduced the LPS-induced expression of some inflammatory cytokines (IL-1beta, IL-12, and CSF2) and chemokines (CCL17 …
20 results