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Investigation of the human H3.3B (H3F3B) gene expression as a novel marker in patients with colorectal cancer.
Ayoubi HA, Mahjoubi F, Mirzaei R. Ayoubi HA, et al. J Gastrointest Oncol. 2017 Feb;8(1):64-69. doi: 10.21037/jgo.2016.12.12. J Gastrointest Oncol. 2017. PMID: 28280610 Free PMC article.
BACKGROUND: H3.3 histone is a replacement histone subtype that is express in entire cell cycle phases and overexpress in transcriptionally active regions, promoter regions, and intergenic or intragenic regulatory elements. This histone encoded by two genes termed H3.3A (H3F3A) an …
BACKGROUND: H3.3 histone is a replacement histone subtype that is express in entire cell cycle phases and overexpress in transcriptionally a …
De novo variants in H3-3A and H3-3B are associated with neurodevelopmental delay, dysmorphic features, and structural brain abnormalities.
Okur V, Chen Z, Vossaert L, Peacock S, Rosenfeld J, Zhao L, Du H, Calamaro E, Gerard A, Zhao S, Kelsay J, Lahr A, Mighton C, Porter HM, Siemon A, Silver J, Svihovec S, Fong CT, Grant CL, Lerner-Ellis J, Manickam K, Madan-Khetarpal S, McCandless SE, Morel CF, Schaefer GB, Berry-Kravis EM, Gates R, Gomez-Ospina N, Qiu G, Zhang TJ, Wu Z, Meng L, Liu P, Scott DA, Lupski JR, Eng CM, Wu N, Yuan B. Okur V, et al. NPJ Genom Med. 2021 Dec 7;6(1):104. doi: 10.1038/s41525-021-00268-8. NPJ Genom Med. 2021. PMID: 34876591 Free PMC article.
The histone H3 variant H3.3, encoded by two genes H3-3A and H3-3B, can replace canonical isoforms H3.1 and H3.2. H3.3 is important in chromatin compaction, early embryonic development, and lineage commitment. ...Here we report eleven de novo missense variants and on …
The histone H3 variant H3.3, encoded by two genes H3-3A and H3-3B, can replace canonical isoforms H3.1 and H3.2. H3.3 is impor …
miR-624 accelerates the growth of liver cancer cells by inhibiting EMC3.
Jiang X, Lu Y, Xie S, Chen Y, Liu X, Li S, Song S, Wang L, Lu D. Jiang X, et al. Noncoding RNA Res. 2023 Sep 24;8(4):641-644. doi: 10.1016/j.ncrna.2023.09.005. eCollection 2023 Dec. Noncoding RNA Res. 2023. PMID: 37810370 Free PMC article.
Interestingly, miR-624 affects the RAB7A interaction network in liver cancer cells, involving in CLTC,ITGB1,HNRNPU, DARS1, RPS16, CTPS1,H3-3B,JUN,MYH10, CUL5, CPSF7. ...These results provide a basis for the treatment of human liver cancer....
Interestingly, miR-624 affects the RAB7A interaction network in liver cancer cells, involving in CLTC,ITGB1,HNRNPU, DARS1, RPS16, CTP …
Lysine-36 of Drosophila histone H3.3 supports adult longevity.
Brown JC, McMichael BD, Vandadi V, Mukherjee A, Salzler HR, Matera AG. Brown JC, et al. G3 (Bethesda). 2024 Apr 3;14(4):jkae030. doi: 10.1093/g3journal/jkae030. G3 (Bethesda). 2024. PMID: 38366796 Free PMC article.
We found that an H3.3BK36R mutation causes a significant reduction in adult lifespan, accompanied by dysregulation of the genomic and transcriptomic architecture. Transgenic co-expression of wild-type H3.3B completely rescues the longevity defect. Because H3.3 is kn …
We found that an H3.3BK36R mutation causes a significant reduction in adult lifespan, accompanied by dysregulation of the genomic and transc …
Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts.
Ors A, Papin C, Favier B, Roulland Y, Dalkara D, Ozturk M, Hamiche A, Dimitrov S, Padmanabhan K. Ors A, et al. Biochem Cell Biol. 2017 Aug;95(4):491-499. doi: 10.1139/bcb-2016-0190. Epub 2017 Feb 1. Biochem Cell Biol. 2017. PMID: 28177753
The presence of H3.3 is thought to positively correlate with the transcriptional status of its target genes. Using a conditional genetic strategy against H3.3B, combined with short hairpin RNAs against H3.3A, we essentially depleted all H3.3 gene expression in mouse …
The presence of H3.3 is thought to positively correlate with the transcriptional status of its target genes. Using a conditional genetic str …
Lysine-36 of Drosophila histone H3.3 supports adult longevity.
Brown JC, McMichael BD, Vandadi V, Mukherjee A, Salzler HR, Matera AG. Brown JC, et al. bioRxiv [Preprint]. 2023 Dec 13:2023.09.28.559962. doi: 10.1101/2023.09.28.559962. bioRxiv. 2023. PMID: 38196611 Free PMC article. Updated. Preprint.
To interrogate the role of this residue in Drosophila developmental gene regulation, we generated a lysine to arginine mutant that blocks the activity of its cognate modifying enzymes. We found that an H3.3B(K36R) mutation causes a significant reduction in adult lif …
To interrogate the role of this residue in Drosophila developmental gene regulation, we generated a lysine to arginine mutant that blocks th …
Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition.
Blumenberg M, Gao S, Dickman K, Grollman AP, Bottinger EP, Zavadil J. Blumenberg M, et al. Cells Tissues Organs. 2007;185(1-3):162-74. doi: 10.1159/000101317. Cells Tissues Organs. 2007. PMID: 17587822 Review.
Here we review context-dependent modules of gene regulation by hairy/enhancer-of-split-related (H/E(spl)) repressors downstream of transforming growth factor-beta (TGF-beta)/Smad and Notch signals in EMT and in other phenotype transitions such as differentiation and cancer …
Here we review context-dependent modules of gene regulation by hairy/enhancer-of-split-related (H/E(spl)) repressors downstream of transform …
Drivers underpinning the malignant transformation of giant cell tumour of bone.
Fittall MW, Lyskjaer I, Ellery P, Lombard P, Ijaz J, Strobl AC, Oukrif D, Tarabichi M, Sill M, Koelsche C, Mechtersheimer G, Demeulemeester J, Tirabosco R, Amary F, Campbell PJ, Pfister SM, Jones DT, Pillay N, Van Loo P, Behjati S, Flanagan AM. Fittall MW, et al. J Pathol. 2020 Dec;252(4):433-440. doi: 10.1002/path.5537. Epub 2020 Oct 6. J Pathol. 2020. PMID: 32866294 Free PMC article.
The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique mutation in the H3.3 family of histone genes H3-3A or H3-3B; however, the same mutation is occasionally found in primary malignant bone tumours which share many features with the benign …
The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique mutation in the H3.3 family of histone genes H3-3A or H3 …
Induction of H3.3 replacement histone mRNAs during the precommitment period of murine erythroleukemia cell differentiation.
Krimer DB, Cheng G, Skoultchi AI. Krimer DB, et al. Nucleic Acids Res. 1993 Jun 25;21(12):2873-9. doi: 10.1093/nar/21.12.2873. Nucleic Acids Res. 1993. PMID: 8332496 Free PMC article.
We show here that the three polyadenylated mRNAs produced from the H3.3B gene, as well as the single mRNA produced from the related H3.3A gene, are coordinately induced during the first few hours of MEL cell differentiation and subsequently down regulated as cells u …
We show here that the three polyadenylated mRNAs produced from the H3.3B gene, as well as the single mRNA produced from the re …
16 results