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HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling.
Zhou Y, Wang K, Zhou Y, Li T, Yang M, Wang R, Chen Y, Cao M, Hu R. Zhou Y, et al. Redox Biol. 2020 Jan;29:101390. doi: 10.1016/j.redox.2019.101390. Epub 2019 Nov 20. Redox Biol. 2020. PMID: 31785531 Free PMC article.
HEATR1 knockdown enhanced proliferation and gemcitabine resistance of pancreatic cancer cells. ...Collectively, we suggest that HEATR1 deficiency promotes proliferation and gemcitabine resistance of pancreatic cancer through up-regulating Nrf2 signalin …
HEATR1 knockdown enhanced proliferation and gemcitabine resistance of pancreatic cancer cells. ...Collectively, we suggest tha …
HEATR1 promotes proliferation in gastric cancer in vitro and in vivo.
Zhao J, Zhu Y, Fu Q, Zhu Y, Zhao G. Zhao J, et al. Acta Biochim Biophys Sin (Shanghai). 2020 Sep 8;52(9):1030-1039. doi: 10.1093/abbs/gmaa077. Acta Biochim Biophys Sin (Shanghai). 2020. PMID: 32634230 Free article.
HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. ...Our results showed that HEATR1 was highly expressed in GC tissues. Higher expressi …
HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 …
HEATR1 modulates cell survival in non-small cell lung cancer via activation of the p53/PUMA signaling pathway.
He S, Ma X, Ye Y, Zhang M, Zhuang J, Song Y, Xia W. He S, et al. Onco Targets Ther. 2019 May 21;12:4001-4011. doi: 10.2147/OTT.S195826. eCollection 2019. Onco Targets Ther. 2019. PMID: 31190896 Free PMC article.
Aim: To determine the mechanisms of HEATR1 on cell survival in non-small cell lung cancer (NSCLC). Methods: HEATR1 mRNA expression levels in 57 pairs of NSCLC tumor and adjacent normal lung tissues were analyzed using the TCGA database. ...In vivo, HEATR1 …
Aim: To determine the mechanisms of HEATR1 on cell survival in non-small cell lung cancer (NSCLC). Methods: HEATR1 mRNA …
HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy.
Liu T, Fang Y, Zhang H, Deng M, Gao B, Niu N, Yu J, Lee S, Kim J, Qin B, Xie F, Evans D, Wang L, Lou W, Lou Z. Liu T, et al. Cancer Res. 2016 Feb 1;76(3):572-81. doi: 10.1158/0008-5472.CAN-15-0671. Epub 2015 Dec 16. Cancer Res. 2016. PMID: 26676747 Free PMC article.
Elucidating mechanisms of chemoresistance is critical to improve cancer therapy, especially for the treatment of pancreatic ductal adenocarcinoma (PDAC). ...Consistent with these findings, treatment with the AKT inhibitor triciribine sensitized HEATR1-depleted PDAC …
Elucidating mechanisms of chemoresistance is critical to improve cancer therapy, especially for the treatment of pancreatic ductal ad …
New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors.
Hu X, Xiao Y, Sun J, Ji B, Luo S, Wu B, Zheng C, Wang P, Xu F, Cheng K, Hua H, Li D. Hu X, et al. Acta Pharm Sin B. 2021 May;11(5):1148-1157. doi: 10.1016/j.apsb.2020.10.019. Epub 2020 Oct 31. Acta Pharm Sin B. 2021. PMID: 34094825 Free PMC article. Review.
Accordingly, H(2)S biosynthesis inhibitors and H(2)S supplementation (H(2)S donors) are two distinct strategies for the treatment of cancer. Unfortunately, modulation of endogenous H(2)S on pancreatic cancer has not been studied so far. ...Exogenous H(2)S donors may …
Accordingly, H(2)S biosynthesis inhibitors and H(2)S supplementation (H(2)S donors) are two distinct strategies for the treatment of canc …
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Yang XM, Wang XQ, Hu LP, Feng MX, Zhou YQ, Li DX, Li J, Miao XC, Zhang YL, Yao LL, Nie HZ, Huang S, Xia Q, Zhang XL, Jiang SH, Zhang ZG. Yang XM, et al. Gastroenterology. 2023 Sep;165(3):629-646. doi: 10.1053/j.gastro.2023.05.029. Epub 2023 May 27. Gastroenterology. 2023. PMID: 37247644
We aimed to identify critical ribosome biogenesis proteins that are overexpressed and crucial in HCC progression. METHODS: HEAT repeat containing 1 (HEATR1) expression and clinical correlations were analyzed using The Cancer Genome Atlas and Gene Expression Omnibus …
We aimed to identify critical ribosome biogenesis proteins that are overexpressed and crucial in HCC progression. METHODS: HEAT repeat conta …
HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer.
Fang Y, Han X, Li J, Kuang T, Lou W. Fang Y, et al. J Oncol. 2020 May 26;2020:3181596. doi: 10.1155/2020/3181596. eCollection 2020. J Oncol. 2020. PMID: 32565799 Free PMC article.
OBJECTIVE: To discover the correlated gene with HEATR1 in regulating chemoresistance of gemcitabine. METHODS: Gene chip analysis was performed to find out differential genes between HEATR1-KD and control groups. ...Patients with high HEATR1 and SMAD4 or low Z …
OBJECTIVE: To discover the correlated gene with HEATR1 in regulating chemoresistance of gemcitabine. METHODS: Gene chip analysis was …
Silencing HEATR1 Rescues Cisplatin Resistance of Non-Small Cell Lung Cancer by Inducing Ferroptosis via the p53/SAT1/ALOX15 Axis.
Ma X, Gan Y, Mai Z, Song Y, Zhang M, Xia W. Ma X, et al. Curr Cancer Drug Targets. 2024 May 30. doi: 10.2174/0115680096284068240506095417. Online ahead of print. Curr Cancer Drug Targets. 2024. PMID: 38818906
However, its resistance to the drug is a major challenge in its clinical application. Earlier research has suggested a connection between HEATR1 and chemoresistance in cancer. However, additional investigation is needed to better understand its involvement in resist …
However, its resistance to the drug is a major challenge in its clinical application. Earlier research has suggested a connection between …
Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.
Diaz LR, Gil-Ranedo J, Jaworek KJ, Nsek N, Marques JP, Costa E, Hilton DA, Bieluczyk H, Warrington O, Hanemann CO, Futschik ME, Bossing T, Barros CS. Diaz LR, et al. EMBO Rep. 2024 Jan;25(1):168-197. doi: 10.1038/s44319-023-00017-1. Epub 2024 Jan 15. EMBO Rep. 2024. PMID: 38225354 Free PMC article.
Cell commitment to tumourigenesis and the onset of uncontrolled growth are critical determinants in cancer development but the early events directing tumour initiating cell (TIC) fate remain unclear. ...High HEATR1 expression correlates with poor glioma patient surv …
Cell commitment to tumourigenesis and the onset of uncontrolled growth are critical determinants in cancer development but the early …
HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma.
Nakamura A, Kakihara Y, Funayama A, Haga K, Mikami T, Kobayashi D, Yoshida Y, Izumi K, Kobayashi T, Saeki M. Nakamura A, et al. Biochem Biophys Res Commun. 2021 Jun 11;557:294-301. doi: 10.1016/j.bbrc.2021.04.021. Epub 2021 Apr 21. Biochem Biophys Res Commun. 2021. PMID: 33894417
Here, we identify HEAT repeat-containing protein 1 (HEATR1) as a novel binding factor of Pontin/Reptin. Functionally, HEATR1 stabilizes Pontin/Reptin and positively regulates OSCC cell proliferation by activating mTOR and pre-rRNA synthesis. We also find that HEA …
Here, we identify HEAT repeat-containing protein 1 (HEATR1) as a novel binding factor of Pontin/Reptin. Functionally, HEATR1 s …
15 results