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Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer.
Uemoto Y, Katsuta E, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, Hisada T, Terada M, Kato A, Okuda K, Sugiura H, Komura M, Kato H, Osaga S, Takahashi S, Toyama T. Uemoto Y, et al. Am J Cancer Res. 2022 Apr 15;12(4):1593-1605. eCollection 2022. Am J Cancer Res. 2022. PMID: 35530276 Free PMC article.
However, the clinical significance and detailed role of HECTD1 in breast cancer remain elusive. We investigated the role of HECTD1 in two large breast cancer cohorts at our institution and The Cancer Genome Atlas using mRNA expression and bioinf …
However, the clinical significance and detailed role of HECTD1 in breast cancer remain elusive. We investigated the role of …
HECTD1 regulates the expression of SNAIL: Implications for epithelial-mesenchymal transition.
Wang X, De Geyter C, Jia Z, Peng Y, Zhang H. Wang X, et al. Int J Oncol. 2020 May;56(5):1186-1198. doi: 10.3892/ijo.2020.5002. Epub 2020 Feb 27. Int J Oncol. 2020. PMID: 32319576 Free PMC article.
Upon the observation of genetic abnormalities in the HECTD1 gene in cervical cancer specimens, it was observed that the decreased expression levels of HECTD1 were significantly associated with a poor patient survival. Thus, it was hypothesized that HECTD1 …
Upon the observation of genetic abnormalities in the HECTD1 gene in cervical cancer specimens, it was observed that the decrea …
Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7.
Frey Y, Franz-Wachtel M, Macek B, Olayioye MA. Frey Y, et al. Sci Rep. 2022 Mar 23;12(1):5036. doi: 10.1038/s41598-022-08844-3. Sci Rep. 2022. PMID: 35322810 Free PMC article.
The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression. ...Thus, we propose o …
The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechani …
HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.
Bennett L, Madders ECET, Parsons JL. Bennett L, et al. Nucleic Acids Res. 2020 Feb 20;48(3):1301-1313. doi: 10.1093/nar/gkz1129. Nucleic Acids Res. 2020. PMID: 31799632 Free PMC article.
We subsequently purified an activity from HeLa cell extracts and identify this as the E3 ubiquitin ligase, HECTD1. We demonstrate that a recombinant truncated form of HECTD1 can stimulate incision of THF-in by APE1 in vitro by histone ubiquitylation, and that siRNA- …
We subsequently purified an activity from HeLa cell extracts and identify this as the E3 ubiquitin ligase, HECTD1. We demonstrate tha …
The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation.
Duhamel S, Goyette MA, Thibault MP, Filion D, Gaboury L, Côté JF. Duhamel S, et al. Cell Rep. 2018 Jan 23;22(4):1016-1030. doi: 10.1016/j.celrep.2017.12.096. Epub 2018 Jan 28. Cell Rep. 2018. PMID: 29386124 Free article.
Cancer cells exploit the epithelial-to-mesenchymal transition (EMT) program to become metastatic. ...A retrospective analysis of biopsies from breast cancer patients also reveals a correlation between higher ACF7 or lower HectD1 expression with poor clinical …
Cancer cells exploit the epithelial-to-mesenchymal transition (EMT) program to become metastatic. ...A retrospective analysis of biop …
Overexpression of BIRC6 driven by EGF-JNK-HECTD1 signaling is a potential therapeutic target for triple-negative breast cancer.
Li Y, Tan Y, Wen L, Xing Z, Wang C, Zhang L, Wu K, Sun H, Li Y, Lei Q, Wu S. Li Y, et al. Mol Ther Nucleic Acids. 2021 Sep 28;26:798-812. doi: 10.1016/j.omtn.2021.09.011. eCollection 2021 Dec 3. Mol Ther Nucleic Acids. 2021. PMID: 34729249 Free PMC article.
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease. The lack of targeted therapies and poor patient outcome have fostered efforts to discover new molecular targets to treat patients with TNBC. ...Mechanistic studies revealed that BIRC6 stabilit …
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease. The lack of targeted therapies and poor patient outc …
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P. Tran H, et al. J Biol Chem. 2013 Feb 8;288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31. J Biol Chem. 2013. PMID: 23277359 Free PMC article.
Knockdown of HectD1 diminished APC ubiquitylation, disrupted the APC-Axin interaction, and augmented Wnt3a-induced beta-catenin stabilization and signaling. These results indicate that HectD1 promotes the APC-Axin interaction to negatively regulate Wnt signaling....
Knockdown of HectD1 diminished APC ubiquitylation, disrupted the APC-Axin interaction, and augmented Wnt3a-induced beta-catenin stabi …
Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis.
Zhang X, Wan M, Min X, Chu G, Luo Y, Han Z, Li W, Xu R, Luo J, Li W, Yang Y, Ma Y, Jiao L, Wang T. Zhang X, et al. CNS Neurosci Ther. 2023 Aug;29(8):2086-2100. doi: 10.1111/cns.14220. Epub 2023 Apr 26. CNS Neurosci Ther. 2023. PMID: 37186176 Free PMC article. Review.
Many recent studies found the potential of circRNAs as biomarkers for many diseases, including cardiovascular diseases, cancers, and ischemic stroke. This systemic review and meta-analysis aimed to identify circRNAs as potential biomarkers for AIS. ...CONCLUSIONS: This stu …
Many recent studies found the potential of circRNAs as biomarkers for many diseases, including cardiovascular diseases, cancers, and …
Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.
Helander S, Montecchio M, Lemak A, Farès C, Almlöf J, Yi Y, Yee A, Arrowsmith C, DhePaganon S, Sunnerhagen M. Helander S, et al. Biochem Biophys Res Commun. 2014 Apr 25;447(1):26-31. doi: 10.1016/j.bbrc.2014.03.068. Epub 2014 Mar 22. Biochem Biophys Res Commun. 2014. PMID: 24667607 Free PMC article.
In this paper, we describe the structure of a N-terminal domain motif in nuclear-localized FKBP251-73, a member of the FKBP family, together with the structure of a sequence-related subdomain of the E3 ubiquitin ligase HectD1 that we show belongs to the same fold. This mot …
In this paper, we describe the structure of a N-terminal domain motif in nuclear-localized FKBP251-73, a member of the FKBP family, together …
LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer.
Meng M, Wu YC. Meng M, et al. J Immunol Res. 2022 Jul 4;2022:7375879. doi: 10.1155/2022/7375879. eCollection 2022. J Immunol Res. 2022. PMID: 35832649 Free PMC article.
Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. ...Furthermore, by utilizing bioinformatics analysis, RIP, RNA pull-down, and luciferase reporter assays, our results showed that LMX1B could bind to …
Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. ...Furthe …
24 results