Mononuclear phagocyte morphologic response to chemoattractants is dependent on geranylgeranyl pyrophosphate.
Krauklis SA, Hussain J, Murphy KM, Dray EL, Ousley CG, Justyna K, Distefano MD, Steelman AJ, McKim DB.
Krauklis SA, et al.
Am J Physiol Endocrinol Metab. 2024 May 8. doi: 10.1152/ajpendo.00359.2023. Online ahead of print.
Am J Physiol Endocrinol Metab. 2024.
PMID: 38717364
Proteomic analysis of C15AlkOPP-prenylated proteins identified several geranylgeranylated proteins involved in chemoattractant responses, including RHOA, RAC1, CDC42, and GNG2. Chemoattractant responses in THP-1 human macrophages were also geranylgeranylation dependent. Th …
Proteomic analysis of C15AlkOPP-prenylated proteins identified several geranylgeranylated proteins involved in chemoattractant responses, in …