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Did you mean hnrnp u (234 results)?
HNRNPU-Related Neurodevelopmental Disorder.
Balasubramanian M. Balasubramanian M. 2022 Mar 10. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2022 Mar 10. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 35274911 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: HNRNPU-related neurodevelopmental disorder (HNRNPU-NDD) is characterized by developmental delay and intellectual disability - typically moderate to severe - with speech and language delay and/or absent speech. ...Agents/circumstances to avo …
CLINICAL CHARACTERISTICS: HNRNPU-related neurodevelopmental disorder (HNRNPU-NDD) is characterized by developmental delay and …
Targeting HNRNPU to overcome cisplatin resistance in bladder cancer.
Shi ZD, Hao L, Han XX, Wu ZX, Pang K, Dong Y, Qin JX, Wang GY, Zhang XM, Xia T, Liang Q, Zhao Y, Li R, Zhang SQ, Zhang JH, Chen JG, Wang GC, Chen ZS, Han CH. Shi ZD, et al. Mol Cancer. 2022 Feb 7;21(1):37. doi: 10.1186/s12943-022-01517-9. Mol Cancer. 2022. PMID: 35130920 Free PMC article.
Epigenetic and transcriptional profiles of HNRNPU-depleted cells after cisplatin treatment were analyzed to investigate the relationship between HNRNPU and cisplatin resistance. ...In the high HNRNPU expressing T24 cancer cells, knockout of HNRNPU inhi …
Epigenetic and transcriptional profiles of HNRNPU-depleted cells after cisplatin treatment were analyzed to investigate the relations …
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression.
Li H, Jiao W, Song J, Wang J, Chen G, Li D, Wang X, Bao B, Du X, Cheng Y, Yang C, Tong Q, Zheng L. Li H, et al. J Exp Clin Cancer Res. 2023 Nov 23;42(1):313. doi: 10.1186/s13046-023-02898-5. J Exp Clin Cancer Res. 2023. PMID: 37993881 Free PMC article.
Mechanistically, circ-hnRNPU physically interacted with non-POU domain containing octamer binding (NONO) protein to induce its cytoplasmic retention, resulting in down-regulation of glycosyltransferases (GALNT2, GALNT6, MGAT1) and parental gene hnRNPU via repression …
Mechanistically, circ-hnRNPU physically interacted with non-POU domain containing octamer binding (NONO) protein to induce its cytopl …
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.
Refaat AM, Nakata M, Husain A, Kosako H, Honjo T, Begum NA. Refaat AM, et al. Cell Rep. 2023 Mar 28;42(3):112284. doi: 10.1016/j.celrep.2023.112284. Epub 2023 Mar 20. Cell Rep. 2023. PMID: 36943867 Free article.
Notably, HNRNPU binds to the S region RNA/DNA G-quadruplexes, contributing to regulating R-loop and single-stranded DNA (ssDNA) accumulation. HNRNPU is an intrinsically disordered protein that interacts with both C-NHEJ and R-loop complexes in an RNA-dependent manne …
Notably, HNRNPU binds to the S region RNA/DNA G-quadruplexes, contributing to regulating R-loop and single-stranded DNA (ssDNA) accum …
DNA methylation episignature and comparative epigenomic profiling of HNRNPU-related neurodevelopmental disorder.
Rooney K, van der Laan L, Trajkova S, Haghshenas S, Relator R, Lauffer P, Vos N, Levy MA, Brunetti-Pierri N, Terrone G, Mignot C, Keren B, de Villemeur TB, Volker-Touw CML, Verbeek N, van der Smagt JJ, Oegema R, Brusco A, Ferrero GB, Misra-Isrie M, Hochstenbach R, Alders M, Mannens MMAM, Sadikovic B, van Haelst MM, Henneman P. Rooney K, et al. Genet Med. 2023 Aug;25(8):100871. doi: 10.1016/j.gim.2023.100871. Epub 2023 Apr 28. Genet Med. 2023. PMID: 37120726 Free article.
PURPOSE: HNRNPU haploinsufficiency is associated with developmental and epileptic encephalopathy 54. ...Correlation analysis identified partial overlap and similarity of the global HNRNPU DNAm profile to several other rare disorders. CONCLUSION: This study demonstra …
PURPOSE: HNRNPU haploinsufficiency is associated with developmental and epileptic encephalopathy 54. ...Correlation analysis identifi …
HNRNPU's multi-tasking is essential for proper cortical development.
Sapir T, Reiner O. Sapir T, et al. Bioessays. 2023 Sep;45(9):e2300039. doi: 10.1002/bies.202300039. Epub 2023 Jul 13. Bioessays. 2023. PMID: 37439444
These functions are critical to ensure the robustness of developmental processes, particularly those involved in shaping the human brain. As a result, HNRNPU is associated with various neurodevelopmental disorders (HNRNPU-related neurodevelopmental disorder, HNRN …
These functions are critical to ensure the robustness of developmental processes, particularly those involved in shaping the human brain. As …
RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor.
Wang X, Xu J, Li Q, Zhang Y, Lin Z, Zhai X, Wang F, Huang J, Gao Q, Wen J, Li L, Feng Y, Luo H, Li Q, Liu X, Li J, Zhao F, Zhang L, Niu T, Sun C, Zheng Y. Wang X, et al. Cancer Lett. 2024 Jan 1;580:216486. doi: 10.1016/j.canlet.2023.216486. Epub 2023 Nov 18. Cancer Lett. 2024. PMID: 37984724
Here we found that hnRNPU regulates MM sensitivity to selinexor. Cell apoptosis assays were performed to compare selinexor-induced cell death in control knockdown (CTR-KD) and hnRNPU knockdown (hnR-KD) MM cells. HnRNPU knockdown-induced nuclear protein retent …
Here we found that hnRNPU regulates MM sensitivity to selinexor. Cell apoptosis assays were performed to compare selinexor-induced ce …
HNRNPU promotes the progression of triple-negative breast cancer via RNA transcription and alternative splicing mechanisms.
Han BY, Liu Z, Hu X, Ling H. Han BY, et al. Cell Death Dis. 2022 Nov 8;13(11):940. doi: 10.1038/s41419-022-05376-6. Cell Death Dis. 2022. PMID: 36347834 Free PMC article.
In this study, we employed an integrated genetic screen to identify a pivotal oncogenic factor, heterogeneous nuclear ribonucleoprotein U (HNRNPU), which is required for the progression of TNBC. We elucidated the pro-oncogenic role of HNRNPU, which can induce the pr …
In this study, we employed an integrated genetic screen to identify a pivotal oncogenic factor, heterogeneous nuclear ribonucleoprotein U ( …
Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome.
Lee S, Ochoa E, Badura-Stronka M, Donnelly D, Lederer D, Lynch SA, Gardham A, Morton J, Stewart H, Docquier F, Rodger F, Martin E, Toribio A, Maher ER, Balasubramanian M. Lee S, et al. Eur J Hum Genet. 2023 Sep;31(9):1040-1047. doi: 10.1038/s41431-023-01422-9. Epub 2023 Jul 5. Eur J Hum Genet. 2023. PMID: 37407733 Free PMC article.
HNRNPU encodes a multifunctional RNA-binding protein that plays critical roles in regulating pre-mRNA splicing, mRNA stability, and translation. Aberrant expression and dysregulation of HNRNPU have been implicated in various human diseases, including cancers and neu …
HNRNPU encodes a multifunctional RNA-binding protein that plays critical roles in regulating pre-mRNA splicing, mRNA stability, and t …
Nuclear organization by satellite DNA, SAF-A/hnRNPU and matrix attachment regions.
Podgornaya OI. Podgornaya OI. Semin Cell Dev Biol. 2022 Aug;128:61-68. doi: 10.1016/j.semcdb.2022.04.018. Epub 2022 Apr 25. Semin Cell Dev Biol. 2022. PMID: 35484025 Review.
It is shown that SAF-A/hnRNPU binds to tandem repeats (TRs) and scaffold/matrix attachment regions (S/MAR) in a sequence-non-specific, but structure-specific manner (e.g. ...The common structural features of S/MAR and pericentromeric (periCEN) TR promotes SAF-A-mediated as …
It is shown that SAF-A/hnRNPU binds to tandem repeats (TRs) and scaffold/matrix attachment regions (S/MAR) in a sequence-non-specific …
218 results