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The cancer/testis antigen HORMAD1 promotes gastric cancer progression by activating the NF-kappaB signaling pathway and inducing epithelial-mesenchymal transition.
Bian G, Li W, Huang D, Zhang Q, Ding X, Zang X, Ye Y, Cao J, Li P. Bian G, et al. Am J Transl Res. 2023 Sep 15;15(9):5808-5825. eCollection 2023. Am J Transl Res. 2023. PMID: 37854207 Free PMC article.
OBJECTIVES: HORMAD1 is a cancer/testis antigen (CTAs) that regulates DNA homologous recombination, mismatch repair, and other tumor characteristics. However, its role and regulatory mechanisms in gastric cancer remain unclear. METHODS: We performed transcript …
OBJECTIVES: HORMAD1 is a cancer/testis antigen (CTAs) that regulates DNA homologous recombination, mismatch repair, and other …
The cancer testes antigen, HORMAD1, limits genomic instability in cancer cells by protecting stalled replication forks.
Herrera LR, Johnson RA, McGlynn K, Gibbs ZA, Davis AJ, Whitehurst AW. Herrera LR, et al. J Biol Chem. 2023 Nov;299(11):105348. doi: 10.1016/j.jbc.2023.105348. Epub 2023 Oct 12. J Biol Chem. 2023. PMID: 37838177 Free PMC article.
Here, we find that HORMAD1 associates with the replisome and is critical for protecting stalled DNA replication forks. Loss of HORMAD1 leads to nascent DNA strand degradation, an event which is mediated by the MRE11-DNA2-BLM pathway. ...
Here, we find that HORMAD1 associates with the replisome and is critical for protecting stalled DNA replication forks. Loss of HOR …
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S. Zong B, et al. Oncol Rep. 2021 Jul;46(1):138. doi: 10.3892/or.2021.8089. Epub 2021 May 26. Oncol Rep. 2021. PMID: 34036395 Free PMC article.
HORMA domain-containing protein 1 (HORMAD1), is normally expressed only in the germline, but is frequently re-activated in human triple-negative breast cancer (TNBC); however, its function in TNBC is largely unknown. ...The role of HORMAD1 in the DNA damage t …
HORMA domain-containing protein 1 (HORMAD1), is normally expressed only in the germline, but is frequently re-activated in human trip …
The cancer/testis antigen HORMAD1 mediates epithelial-mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/beta-catenin signaling pathway in lung cancer.
Liu K, Cheng L, Zhu K, Wang J, Shu Q. Liu K, et al. Cell Death Discov. 2022 Mar 28;8(1):136. doi: 10.1038/s41420-022-00946-1. Cell Death Discov. 2022. PMID: 35347116 Free PMC article.
The cancer/testis antigen HORMAD1 is a mechanical regulator that modulates DNA homologous recombination repair and mismatch repair in multiple cancers. ...Our results provide new insights into the functional role and regulatory mechanism of HORMAD1 in …
The cancer/testis antigen HORMAD1 is a mechanical regulator that modulates DNA homologous recombination repair and mismatch re …
The Cancer Testes Antigen, HORMAD1, is a Tumor-Specific Replication Fork Protection Factor.
Herrera LR, McGlynn K, Gibbs ZA, Davis AJ, Whitehurst AW. Herrera LR, et al. bioRxiv [Preprint]. 2023 Feb 3:2023.01.31.526348. doi: 10.1101/2023.01.31.526348. bioRxiv. 2023. PMID: 36778501 Free PMC article. Preprint.
We previously found that HORMAD1 promotes DNA double strand break (DSB) repair in LUAD. Here, we report that HORMAD1 takes on an additional role in protecting genomic integrity. Specifically, we find HORMAD1 is critical for protecting stalled DNA replication …
We previously found that HORMAD1 promotes DNA double strand break (DSB) repair in LUAD. Here, we report that HORMAD1 takes on …
The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
Gao Y, Kardos J, Yang Y, Tamir TY, Mutter-Rottmayer E, Weissman B, Major MB, Kim WY, Vaziri C. Gao Y, et al. Sci Rep. 2018 Oct 17;8(1):15304. doi: 10.1038/s41598-018-33601-w. Sci Rep. 2018. PMID: 30333500 Free PMC article.
The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antigen on c …
The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of m …
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, Shen Y, Cheng X, Lu LY, Liu Y. Liu K, et al. Cell Death Dis. 2020 Jul 9;11(7):519. doi: 10.1038/s41419-020-2736-1. Cell Death Dis. 2020. PMID: 32647118 Free PMC article.
Originally identified as a cancer/testis antigen, HORMAD1 is also aberrantly expressed in several cancers. However, the functions of HORMAD1 in cancer cells are still not clear. Here, we show that HORMAD1 is aberrantly expressed in a wide …
Originally identified as a cancer/testis antigen, HORMAD1 is also aberrantly expressed in several cancers. However, the …
Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas.
Gantchev J, Messina-Pacheco J, Martínez Villarreal A, Ramchatesingh B, Lefrançois P, Xie P, Amar L, Xu HH, Raveendra K, Sikorski D, Guerra Ordaz DJ, Gill RPK, Lambert M, Litvinov IV. Gantchev J, et al. Cells. 2023 Jun 14;12(12):1627. doi: 10.3390/cells12121627. Cells. 2023. PMID: 37371097 Free PMC article.
These meiotic genes may represent novel therapeutic targets for the treatment of cancer. We studied the relationship between the expression of the meiosis protein HORMAD1 and genomic instability in squamous cell carcinomas (SCCs). First, we assessed markers of DNA d …
These meiotic genes may represent novel therapeutic targets for the treatment of cancer. We studied the relationship between the expr …
Epigenetic activation of HORMAD1 in basal-like breast cancer: role in Rucaparib sensitivity.
Wang X, Tan Y, Cao X, Kim JA, Chen T, Hu Y, Wexler M, Wang X. Wang X, et al. Oncotarget. 2018 Jul 10;9(53):30115-30127. doi: 10.18632/oncotarget.25728. eCollection 2018 Jul 10. Oncotarget. 2018. PMID: 30046392 Free PMC article.
Basal-like breast cancer (BLBC) is an aggressive breast cancer subtype with features similar to the basal cells surrounding the mammary ducts. ...On the other hand, investigation of the Genomics of Drug Sensitivity in Cancer dataset revealed significantly red …
Basal-like breast cancer (BLBC) is an aggressive breast cancer subtype with features similar to the basal cells surrounding th …
43 results