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1994 2
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357 results

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Page 1
HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis.
Song C, Zhou C. Song C, et al. J Exp Clin Cancer Res. 2021 Feb 9;40(1):62. doi: 10.1186/s13046-021-01859-0. J Exp Clin Cancer Res. 2021. PMID: 33563300 Free PMC article.
We previously demonstrated that HOXA10 was significantly upregulated in gastric cancer (GC) and promoted GC cell proliferation. This study was designed to investigate the role of HOXA10 in GC metastasis and explore the underlying mechanism. METHODS: Immunohis …
We previously demonstrated that HOXA10 was significantly upregulated in gastric cancer (GC) and promoted GC cell proliferation …
ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer.
Nie S, Zhang L, Liu J, Wan Y, Jiang Y, Yang J, Sun R, Ma X, Sun G, Meng H, Xu M, Cheng W. Nie S, et al. J Exp Clin Cancer Res. 2021 Sep 8;40(1):284. doi: 10.1186/s13046-021-02088-1. J Exp Clin Cancer Res. 2021. PMID: 34496932 Free PMC article.
BACKGROUND: Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC). ALKBH5 has recently been shown to be one of the RNA N6-methyladenosine (m6A) demethyltransferases associated with various cancers, but its role in …
BACKGROUND: Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC). ALKBH5 has recen …
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P. Qu Y, et al. Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Free article. Review.
Gastric cancer is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide. ...Aberrant DNA methylation in the promoter regions of gene, which leads to inactivation of tumor suppressor and other cancer-related …
Gastric cancer is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide. …
+HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10.
Cao F, Zheng Y, Yang C, Huang S, He X, Tong S. Cao F, et al. Comput Math Methods Med. 2022 Feb 16;2022:1846687. doi: 10.1155/2022/1846687. eCollection 2022. Comput Math Methods Med. 2022. Retraction in: Comput Math Methods Med. 2023 Jun 28;2023:9780309. doi: 10.1155/2023/9780309. PMID: 35222681 Free PMC article. Retracted.
OBJECTIVE: To study the role of long noncoding RNA HOXA10-AS in gastric cancer (GC) and its underlying mechanism which is one of the most common and fetal malignancies. Long noncoding RNA HOXA10-AS is highly expressed and acts in an oncogenic role in cance
OBJECTIVE: To study the role of long noncoding RNA HOXA10-AS in gastric cancer (GC) and its underlying mechanism which is one …
HOXA10 deteriorates gastric cancer through activating JAK1/STAT3 signaling pathway.
Chen W, Wu G, Zhu Y, Zhang W, Zhang H, Zhou Y, Sun P. Chen W, et al. Cancer Manag Res. 2019 Jul 15;11:6625-6635. doi: 10.2147/CMAR.S201342. eCollection 2019. Cancer Manag Res. 2019. PMID: 31406476 Free PMC article.
Background: HOXA10 has been reported to be deregulated in many kinds of cancers including gastric cancer. But its role in gastric cancer progression is controversial. Therefore, the current study was performed to explore the role and mechanism of HO
Background: HOXA10 has been reported to be deregulated in many kinds of cancers including gastric cancer. But its role …
HOXA10 expression profiling in prostate cancer.
Hatanaka Y, de Velasco MA, Oki T, Shimizu N, Nozawa M, Yoshimura K, Yoshikawa K, Nishio K, Uemura H. Hatanaka Y, et al. Prostate. 2019 Apr;79(5):554-563. doi: 10.1002/pros.23761. Epub 2019 Jan 6. Prostate. 2019. PMID: 30614022
RESULTS: A meta-analysis of HOXA10 gene expression indicated dysregulated expression of HOXA10 in human PCa. ...This study provides human and mouse evidence to suggest tumor suppressive roles for HOXA10 in the context of prostate cancer....
RESULTS: A meta-analysis of HOXA10 gene expression indicated dysregulated expression of HOXA10 in human PCa. ...This study pro …
HOXA10 promotes the development of bladder cancer through regulating FOSL1.
Cui YP, Xie M, Pan WX, Zhang ZY, Li WF. Cui YP, et al. Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):2945-2954. doi: 10.26355/eurrev_202003_20659. Eur Rev Med Pharmacol Sci. 2020. PMID: 32271412 Free article.
OBJECTIVE: This study was aimed to investigate the expression characteristics of HOXA10 in bladder cancer (BCa), and to further study whether it can promote the development of BCa via regulating FOSL1. ...In addition, HOXA10 may be able to accelerate BCa meta …
OBJECTIVE: This study was aimed to investigate the expression characteristics of HOXA10 in bladder cancer (BCa), and to furthe …
Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer.
Mishra A, Ganguli N, Majumdar SS, Modi D. Mishra A, et al. J Mol Endocrinol. 2022 Aug 26;69(3):431-444. doi: 10.1530/JME-22-0051. Print 2022 Oct 1. J Mol Endocrinol. 2022. PMID: 35917434
Herein, using testicular transgenesis, we developed transgenic mice that expressed a shRNA against HOXA10 and there was a nearly 70% reduction in the expression of HOXA10 in these animals. ...In parallel, there was increased expression of Wnt4 and beta-Catenin, SOX9 …
Herein, using testicular transgenesis, we developed transgenic mice that expressed a shRNA against HOXA10 and there was a nearly 70% …
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-kappaB signaling pathway.
Li J, Chang J, Wang J, Xu D, Yang M, Jiang Y, Zhang J, Jiang X, Sun Y. Li J, et al. Carcinogenesis. 2022 Sep 19;43(8):787-796. doi: 10.1093/carcin/bgac042. Carcinogenesis. 2022. PMID: 35553652
METHODS: Immunohistochemistry assays were applied to demonstrate the relationship between HOXA10 expression and PDAC progression. Functional assays were used to illustrate the oncogenic role of HOXA10 in PDAC progression. ...RESULTS: In the current study, we show th …
METHODS: Immunohistochemistry assays were applied to demonstrate the relationship between HOXA10 expression and PDAC progression. Fun …
Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression.
Chen YT, Kan CH, Liu H, Liu YH, Wu CC, Kuo YP, Chang IY, Chang KP, Yu JS, Tan BC. Chen YT, et al. Cell Death Dis. 2022 Jul 20;13(7):629. doi: 10.1038/s41419-022-05071-6. Cell Death Dis. 2022. PMID: 35858923 Free PMC article.
Functional cell-based assays show that the HOXA10-AS transcript is essential in the regulation of oral cancer growth and metastasis. LncRNA expression is also associated with drug sensitivity. In this study, we identify that HOXA10-AS serves as a modular scaf …
Functional cell-based assays show that the HOXA10-AS transcript is essential in the regulation of oral cancer growth and metas …
357 results