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Year Number of Results
1981 2
1983 4
1984 1
1985 1
1986 3
1988 1
1989 1
1991 2
1992 1
1993 6
1994 3
1995 1
1996 4
1997 8
1998 16
1999 30
2000 55
2001 50
2002 76
2003 51
2004 55
2005 100
2006 106
2007 109
2008 105
2009 84
2010 85
2011 103
2012 116
2013 113
2014 111
2015 100
2016 103
2017 100
2018 104
2019 117
2020 101
2021 98
2022 101
2023 80
2024 43

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2,100 results

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Page 1
HSPB1 as a novel regulator of ferroptotic cancer cell death.
Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, Wang H, Cao L, Tang D. Sun X, et al. Oncogene. 2015 Nov 5;34(45):5617-25. doi: 10.1038/onc.2015.32. Epub 2015 Mar 2. Oncogene. 2015. PMID: 25728673 Free PMC article.
Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 …
Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. …
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition.
Lu S, Hu J, Arogundade OA, Goginashvili A, Vazquez-Sanchez S, Diedrich JK, Gu J, Blum J, Oung S, Ye Q, Yu H, Ravits J, Liu C, Yates JR 3rd, Cleveland DW. Lu S, et al. Nat Cell Biol. 2022 Sep;24(9):1378-1393. doi: 10.1038/s41556-022-00988-8. Epub 2022 Sep 8. Nat Cell Biol. 2022. PMID: 36075972 Free PMC article.
A decrease in HSPB1 promotes cytoplasmic TDP-43 de-mixing and mislocalization. ...These findings identify HSPB1 to be a regulator of cytoplasmic TDP-43 phase separation and aggregation....
A decrease in HSPB1 promotes cytoplasmic TDP-43 de-mixing and mislocalization. ...These findings identify HSPB1 to be a regula …
HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-kappaB signaling pathway in breast cancer.
Liang Y, Wang Y, Zhang Y, Ye F, Luo D, Li Y, Jin Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Chen X, Ma T, Kong X, Yang Q. Liang Y, et al. Cell Death Dis. 2023 Jul 15;14(7):434. doi: 10.1038/s41419-023-05972-0. Cell Death Dis. 2023. PMID: 37454220 Free PMC article.
Functional assays revealed that HSPB1 could promote cancer growth and metastasis in vitro and in vivo. ...These findings revealed that HSPB1 upregulation might be a key driver to progression and chemoresistance through regulating ferroptosis in breast cancer while t …
Functional assays revealed that HSPB1 could promote cancer growth and metastasis in vitro and in vivo. ...These findings revealed tha …
Mutations in HspB1 and hereditary neuropathies.
Muranova LK, Sudnitsyna MV, Strelkov SV, Gusev NB. Muranova LK, et al. Cell Stress Chaperones. 2020 Jul;25(4):655-665. doi: 10.1007/s12192-020-01099-9. Epub 2020 Apr 16. Cell Stress Chaperones. 2020. PMID: 32301006 Free PMC article. Review.
CMT has been linked to mutations in a range of proteins, including the small heat shock protein HspB1. Here we review the properties of several HspB1 mutants associated with CMT. ...In addition, mutations of HspB1 can affect the metabolism in astroglia and in …
CMT has been linked to mutations in a range of proteins, including the small heat shock protein HspB1. Here we review the properties …
A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes.
Yang W, Gao K, Qian Y, Huang Y, Xiang Q, Chen C, Chen Q, Wang Y, Fang F, He Q, Chen S, Xiong J, Chen Y, Xie N, Zheng D, Zhai R. Yang W, et al. J Hematol Oncol. 2022 May 7;15(1):53. doi: 10.1186/s13045-022-01270-y. J Hematol Oncol. 2022. PMID: 35526007 Free PMC article.
Mechanistically, AS-tDR-007333 promoted the malignancy of NSCLC cells by activating MED29 through two distinct mechanisms. First, AS-tDR-007333 bound to and interacted with HSPB1, which activated MED29 expression by enhancing H3K4me1 and H3K27ac in MED29 promoter. ...CONCL …
Mechanistically, AS-tDR-007333 promoted the malignancy of NSCLC cells by activating MED29 through two distinct mechanisms. First, AS-tDR-007 …
HSPB1, actin filament dynamics, and aging cells.
Doshi BM, Hightower LE, Lee J. Doshi BM, et al. Ann N Y Acad Sci. 2010 Jun;1197:76-84. doi: 10.1111/j.1749-6632.2010.05191.x. Ann N Y Acad Sci. 2010. PMID: 20536836 Review.
Most studies have employed cell-free extracts and purified proteins. For example, HSPB1 is known to bind actin in vitro, and this observation led to the hypothesis that HSPB1 regulates actin filament dynamics. ...These results show that HSPB1 and actin form a …
Most studies have employed cell-free extracts and purified proteins. For example, HSPB1 is known to bind actin in vitro, and this obs …
Mammalian HspB1 (Hsp27) is a molecular sensor linked to the physiology and environment of the cell.
Arrigo AP. Arrigo AP. Cell Stress Chaperones. 2017 Jul;22(4):517-529. doi: 10.1007/s12192-017-0765-1. Epub 2017 Jan 31. Cell Stress Chaperones. 2017. PMID: 28144778 Free PMC article. Review.
Constitutively expressed small heat shock protein HspB1 regulates many fundamental cellular processes and plays major roles in many human pathological diseases. ...Here, I have reviewed data from the literature and re-analyzed my own studies to describe and discuss these f …
Constitutively expressed small heat shock protein HspB1 regulates many fundamental cellular processes and plays major roles in many h …
HspB1 dynamic phospho-oligomeric structure dependent interactome as cancer therapeutic target.
Arrigo AP, Gibert B. Arrigo AP, et al. Curr Mol Med. 2012 Nov 1;12(9):1151-63. doi: 10.2174/156652412803306693. Curr Mol Med. 2012. PMID: 22804238 Review.
A large number of HspB1 interacting partners have already been described in the literature. ...In cancer, HspB1 is tumorigenic, stimulates metastasis and provide cancer cells with resistance to many anti-cancer drugs, so compounds aimed at disrupting HspB1 de …
A large number of HspB1 interacting partners have already been described in the literature. ...In cancer, HspB1 is tumorigenic …
HspB1 (Hsp 27) expression and neuroprotection in the retina.
O'Reilly AM, Currie RW, Clarke DB. O'Reilly AM, et al. Mol Neurobiol. 2010 Oct;42(2):124-32. doi: 10.1007/s12035-010-8143-3. Epub 2010 Jun 2. Mol Neurobiol. 2010. PMID: 20514530 Review.
Notably, HspB1 has powerful neuroprotective effects, increasing the survival of cells subjected to cytotoxic stimuli. ...Finally, the potential of HspB1 as a clinical therapeutic will be examined....
Notably, HspB1 has powerful neuroprotective effects, increasing the survival of cells subjected to cytotoxic stimuli. ...Finally, the …
HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model.
Alexander CC, Munkáscy E, Tillmon H, Fraker T, Scheirer J, Holstein D, Lozano D, Khan M, Gidalevitz T, Lechleiter JD, Fisher AL, Zare H, Rodriguez KA. Alexander CC, et al. J Gerontol A Biol Sci Med Sci. 2022 Feb 3;77(2):268-275. doi: 10.1093/gerona/glab296. J Gerontol A Biol Sci Med Sci. 2022. PMID: 34610126 Free PMC article.
To explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in rodents and Hsp27 in humans) in longevity, we created a Caenorhabiditis elegans model with a high level of ubiquitous expression of the naked mole-rat HspB1 protein. ...RNAseq …
To explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in rodents and Hsp27 in humans) in longevity, …
2,100 results