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HTR7 promotes laryngeal cancer growth through PI3K/AKT pathway activation.
Sheng X, Liu W, Lu Z, Xu M, Li R, Zhong R, Li Y, Liu T, Zhang S. Sheng X, et al. Ann Transl Med. 2021 May;9(10):840. doi: 10.21037/atm-21-1069. Ann Transl Med. 2021. PMID: 34164474 Free PMC article.
Cell proliferation assays and an animal model showed that HTR7 overexpression promoted laryngeal cancer proliferation and growth, while HTR7 knockdown inhibited laryngeal cancer proliferation and growth. ...CONCLUSIONS: HTR7 is not only a target …
Cell proliferation assays and an animal model showed that HTR7 overexpression promoted laryngeal cancer proliferation and grow …
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D. Meyer N, et al. Autophagy. 2021 Nov;17(11):3424-3443. doi: 10.1080/15548627.2021.1874208. Epub 2021 Jan 19. Autophagy. 2021. PMID: 33461384 Free PMC article.
The results also support the notion that simultaneous overactivation of autophagy and induction of LMP represents a promising approach for the treatment of GBM.Abbreviations: ACD: autophagic cell death; AKT1: AKT serine/threonine kinase 1; ATG5: autophagy related 5; ATG7: autopha …
The results also support the notion that simultaneous overactivation of autophagy and induction of LMP represents a promising approach for t …
Integrative dissection of 5-hydroxytryptamine receptors-related signature in the prognosis and immune microenvironment of breast cancer.
Zhan D, Wang X, Zheng Y, Wang S, Yang B, Pan B, Wang N, Wang Z. Zhan D, et al. Front Oncol. 2023 Sep 19;13:1147189. doi: 10.3389/fonc.2023.1147189. eCollection 2023. Front Oncol. 2023. PMID: 37795441 Free PMC article.
Zebrafish and mouse breast cancer xenografts were used to determine the effect of HTR2A/2B inhibitor on breast cancer metastasis. RESULTS: The expression levels of HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR4, and HTR7 were significantly downregulated in highly ma …
Zebrafish and mouse breast cancer xenografts were used to determine the effect of HTR2A/2B inhibitor on breast cancer metastas …
In colonic rho(0) (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer.
Penrose HM, Heller S, Cable C, Nakhoul H, Ungerleider N, Baddoo M, Pursell ZF, Flemington EK, Crawford SE, Savkovic SD. Penrose HM, et al. Oncoscience. 2017 Dec 27;4(11-12):189-198. doi: 10.18632/oncoscience.386. eCollection 2017 Nov. Oncoscience. 2017. PMID: 29344557 Free PMC article.
BACKGROUND: Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming is essential for cancer cells to thrive, how it supports cancer pathobiology is unclear. ...We identified and validated novel …
BACKGROUND: Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming …
Serotonin modulation of macrophage polarization: inflammation and beyond.
de Las Casas-Engel M, Corbí AL. de Las Casas-Engel M, et al. Adv Exp Med Biol. 2014;824:89-115. doi: 10.1007/978-3-319-07320-0_9. Adv Exp Med Biol. 2014. PMID: 25038996 Review.
As a consequence, deregulation of the tissue macrophage polarization balance is an etiological agent of chronic inflammation, autoimmune diseases, cancer and even obesity and insulin resistance. In the present review we describe current concepts on the molecular basis and …
As a consequence, deregulation of the tissue macrophage polarization balance is an etiological agent of chronic inflammation, autoimmune dis …
Effect of exosome biomarkers for diagnosis and prognosis of breast cancer patients.
Wang M, Ji S, Shao G, Zhang J, Zhao K, Wang Z, Wu A. Wang M, et al. Clin Transl Oncol. 2018 Jul;20(7):906-911. doi: 10.1007/s12094-017-1805-0. Epub 2017 Nov 15. Clin Transl Oncol. 2018. PMID: 29143228
For diagnosis evaluation, the comparison of exosome biomarkers expression between breast cancer patients and healthy women was obtained; for prognosis prediction, the correlation between exosome biomarkers expression and chemotherapy resistance, overall survival (OS), dise …
For diagnosis evaluation, the comparison of exosome biomarkers expression between breast cancer patients and healthy women was obtain …
Serotonin Receptors and Acetylcholinesterase Gene Expression Alternations: The Potential Value on Tumor Microenvironment of Gastric Cancer.
Abedini F, Amjadi O, Hedayatizadeh-Omran A, Lira SA, Ahangari G. Abedini F, et al. Oncology. 2023;101(7):415-424. doi: 10.1159/000530878. Epub 2023 May 3. Oncology. 2023. PMID: 37231904
INTRODUCTION: Gastric cancer is one of the common causes of cancer-related death in the world. ...RESULTS: Significantly higher amounts of 5-HTR2A, 5-HTR2B, 5-HTR3A, 5-HTR7, and acetylcholinesterase gene transcripts were found in the peripheral blood of gastr …
INTRODUCTION: Gastric cancer is one of the common causes of cancer-related death in the world. ...RESULTS: Significantly highe …
Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1.
Cınar V, Hamurcu Z, Guler A, Nurdinov N, Ozpolat B. Cınar V, et al. Breast Cancer. 2022 Nov;29(6):1106-1120. doi: 10.1007/s12282-022-01391-9. Epub 2022 Aug 25. Breast Cancer. 2022. PMID: 36006564
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with poor prognosis and shorter survival due to significant genetic heterogeneity, drug resistance and lack of effective targeted therapeutics. ...Also, genetic an …
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with poor prognosis and …
Preliminary Study on the Sequencing of Whole Genomic Methylation and Transcriptome-Related Genes in Thyroid Carcinoma.
Iqbal MA, Li M, Lin J, Zhang G, Chen M, Moazzam NF, Qian W. Iqbal MA, et al. Cancers (Basel). 2022 Feb 24;14(5):1163. doi: 10.3390/cancers14051163. Cancers (Basel). 2022. PMID: 35267472 Free PMC article.
Thyroid carcinoma is the most prevalent endocrine cancer globally and the primary cause of cancer-related mortality. ...Our study revealed that the whole-genome DNA methylation patterns and gene expression profiles in thyroid cancer shed new light on the tumo …
Thyroid carcinoma is the most prevalent endocrine cancer globally and the primary cause of cancer-related mortality. ...Our st …
16 results